Obesity is a widespread multifactorial, multisystem disease associated with a high incidence of cardiovascular diseases. Dosed physical activity is one of the main therapeutic measures for this category of patients. The combination of physical training with climatotherapy (terrain therapy) accumulates a therapeutic effect. However, it is necessary to take into account the external meteorological conditions and meteotropic reactions that occur in patients, which can neutralize the achieved therapeutic effect. The purpose of the study was to investigate the prevalence of meteoropathic reactions in patients who arrived for resort treatment, their association with comorbidities,and interdependence with the region of permanent residence. In order to determine the severity of meteoropathic reactions and their main manifestations, a cross-sectional study was conducted, involving 735 patients with a body mass index of 25–29.9 kg/m2 or higher who were treated at the Resort Complex «Vulan» in the period from February 1, 2021 to April 1, 2022. As a tool for assessing meteoropathic reactions, a retrospective questionnaire «Meteoropathy» (research work No. A AAA-A18‑118022890045‑6) was used.