Cardiovascular effects induced by <i>Cymbopogon winterianus</i> essential oil in rats: involvement of calcium channels and vagal pathway

Menezes, Igor Alexandre Côrtes de; Moreira, Ítalo José Alves; Paula, José Welton Azevedo de; Blank, Arie Fitzgerald; Antoniolli, Ângelo Roberto; Quintans‐Júnior, Lucindo José; Santos, Márcio Roberto Viana dos

doi:10.1211/jpp.62.02.0009

Cited by 38 publications

(24 citation statements)

References 18 publications

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“…This compound was also identified as a major component of the essential oil of C. isabelli, which presents amoebicidal activity (VUNDA et al, 2012), hence the studied species may have amoebicidal potential. In the present study, β-pinene was the second major compound of C. sincorensis, which has been reported in literature as presenting antimicrobial (SILVA et al, 2012), antidepressant (GUZMÁN-GUTIERREZ et al, 2012), and hypotensive properties (MENEZES et al, 2010). It is also reported that α-pinene, β-pinene, and 1,8-cineole, which are found in C. argyrophylloides and C. sincorensis species, present antibacterial properties (LEITE et al, 2007).…”

Section: Harvest Time Vs Species -----------------------------------supporting

confidence: 71%

Chemical composition and yield of essential oil from three Croton species

Souza¹,

Bonilla

Lucena

et al. 2017

Cienc. Rural

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Marmeleiros are popularly known for the medicinal properties ascribed to their essential oils. This research aimed to analyze the essential oil of leaves from three Croton species (Croton argyrophylloides, Croton jacobinensis, and Croton sincorensis), to verify whether the daily time and harvest season in the year may interfere with their essential oils performance and composition. From each species, 1,500g of green leaves were harvested in Viçosa do Ceará - CE, at 6am and 12pm, during both dry and rainy seasons. Essential oil extraction was conducted by the method of water vapor drag and chemical profile was analyzed by gas chromatography-mass spectrometry (GC/MS). The highest yield was obtained at 12pm in the dry season for C. argyrophylloides and C. jacobinensis, and at 6am in the rainy season for C. sincorensis. Bicyclogermacrene demonstrated higher relative abundance in C. argyrophylloides (28.09 to 30.59%), C. jacobinensis (25.2 to 30.14%), and C. sincorensis (23.86 and 21.71%), and the only exception was at 6am in C. sincorensis, where (E)-caryophyllene was the most abundant compound (25.34%). The yield and composition of the studied species were influenced by rainfall, temperature, and sunlight, presenting statistical significant differences between the different periods studied. The species produce constituents with specific biological properties; and therefore, they can be used as a natural source.

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Section: Harvest Time Vs Species -----------------------------------supporting

confidence: 71%

Chemical composition and yield of essential oil from three Croton species

Souza¹,

Bonilla

Lucena

et al. 2017

Cienc. Rural

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“…Muscarine (2.5 µg/kg) was then infused into the same animal, after the BP and HR returned to the level prior to the infusion of the MLE. The drugs were infused 20 minutes after atropine infusion (Thán et al, 2000;Dimo et al, 2003;Dabire, 2004;Adami et al, 2006;Ajay et al, 2007; D. Holopherne et al, 2008;Khwanchuea et al, 2008;Lessa et al, 2008;Rattmann et al, 2008;De Menezes et al, 2010).…”

Section: D)mentioning

confidence: 99%

“…The prominent BP profile and magnitude was that of atropine ( figure 4.44 a). Infusion of agonists was done 20 minutes after infusing atropine in most studies in which atropine was used to block the muscarinic receptors (Muntzel et al, 1997;Dimo et al, 2003;Delphine Holopherne et al, 2008;Khwanchuea et al, 2008;Lessa et al, 2008;Liu et al, 2008;Rattmann et al, 2008;Shirasaka et al, 2009;De Menezes et al, 2010). violacea were significantly (p < 0.05) higher than those observed with muscarine after pretreatment of animals with atropine.…”

Section: Does T Violacea Act By Blocking the Beta I Adrenoceptors?mentioning

confidence: 99%

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Raji

Mugabo

Obikeze

2012

Journal of Ethnopharmacology

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Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats I. A. RAJITulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension (HTN) and stomach problems. The aim of this study was to evaluate the effect of methanol leaf extracts (MLE) of T. violacea on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats; and to find out the mechanism(s) by which it acts.The MLE of T. violacea (5 -150 mg/kg), angiotensin I (ang I, 3.1 -100 µg/kg), captopril (10 mg/kg), angiotensin II (ang II, 3.1 -50 µg/kg), losartan (30 mg/kg), phenylephrine T. violacea (60 mg/kg) and captopril (10 mg/kg) were injected intraperitoneally into iii some SHR for 21 days to investigate the chronic effect of these agents on plasma levels of aldosterone. The mean change, the mean of the individual percentage changes and the percentage difference (in mean) observed with each intervention was calculated and statistically analyzed using the Student's t test for significant difference (p < 0.05). The Microsoft Excel software was used for statistical analysis.T. violacea significantly (p < 0.05) reduced the systolic, diastolic, and mean arterial BP;and HR dose-dependently. In a dose-dependent manner, ang I, ang II, phenylephrine significantly (p < 0.05) increased the BP, while propranolol, muscarine and atropine reduced the BP. The increases in BP due to dobutamine were not dose-dependent. In a dose dependent manner, phenylephrine and propranolol reduced the HR, while dobutamine increased the HR. The effect of ang I, ang II, muscarine and atropine on HR were not dose-dependent; with both increases as well as decreases observed with ang I, and II and atropine, while decreases were seen with muscarine. Captopril produced significant (p < 0.05) reduction in BP which were not associated with any change in HR.The co-infusion of ang I with the MLE produced significant (p < 0.05) reduction in BP, which were not associated with significant changes in HR. The co-infusion of ang II with the MLE did not produce any significant changes in BP or HR when compared to the infusion of the standard drug alone. The co-infusion of phenylephrine with the MLE did

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“…An increasing number of studies have demonstrated that essential oils derived plant exhibit a variety of biological properties, such as analgesic (McCurdy & Scully, 2005), hypotensive (Menezes et al, 2010) and anticonvulsant activities (QuintansJúnior et al, 2008a;Silva et al, 2010). Monoterpenes are the primary components of these essential oils and the effects of many medicinal herbs have been attributed to them (Lima-Accioly et al, 2006;Quintans-Júnior et al, 2008b), including the studies realized by our group (De Sousa et al, 2006;Melo et al, 2010;Quintans-Júnior et al, 2010;Guimarães et al, 2010).…”

Section: Introductionmentioning

confidence: 88%

Citral reduces nociceptive and inflammatory response in rodents

Quintans‐Júnior¹,

Guimarães²,

Santana³

et al. 2011

Rev. bras. farmacogn.

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Citral (CIT), which contains the chiral enantiomers, neral (cis) and geranial (trans), is the majority monoterpene from Lippia alba and Cymbopogon citratus. The present study aimed to evaluate CIT for antinociceptive and antiinflammatory activities in rodents. Antinociceptive and anti-inflammatory effects were studied by measuring nociception through acetic acid and formalin tests, while inflammation was verified by inducing peritonitis and paw edema with carrageenan. All tested doses of CIT had significant protection (p<0.001) against acetic acid (0.8%) induced nociceptive behavior and the effects were also similar to morphine while formalin induced nociception was significantly protected (p<0.05) only at higher dose (200 mg/kg) of CIT in the first phase of the test. CIT significantly reduce (p<0.001) nociceptive behavior emanating from inflammation in second phase at all the doses.The pretreatment with CIT (100 and 200 mg/kg) significantly reduced the paw edema induced by carrageenan. Moreover, systemic treatment with CIT (100 and 200 mg/kg) significantly reduced (p<0.001) the leukocyte migration in the carrageenaninduced migration to the peritoneal cavity. Our investigation shows that CIT possess significant central and peripheral antinociceptive effects. It was also verified an anti-inflammatory activity. All together these results suggest that CIT might represent important tool for treatment of painful conditions.

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Cardiovascular effects induced by Cymbopogon winterianus essential oil in rats: involvement of calcium channels and vagal pathway

Cited by 38 publications

References 18 publications

Chemical composition and yield of essential oil from three Croton species

Chemical composition and yield of essential oil from three Croton species

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Citral reduces nociceptive and inflammatory response in rodents

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