Cardiovascular effects of dietary copper deficiency

Saari, Jack T.; Schuschke, Dale A.

doi:10.1002/biof.5520100406

Cited by 47 publications

(31 citation statements)

References 148 publications

(338 reference statements)

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“…In our previous study [4], we also observed that iron, copper, and zinc intake by hypertensive patients were below the recommended dietary intake level. It is suggested that diet copper deficiency may contribute to high blood pressure [26]. In the study of Klevay [27], it was found that women on diets of conventional food low in copper had increased blood pressure and hypercholesterolemia, whereas Zagar et al [28] a reported relationship between higher serum copper and non-insulin diabetes mellitus.…”

Section: Discussionmentioning

confidence: 97%

Dietary Intake and Serum and Hair Concentrations of Minerals and their Relationship with Serum Lipids and Glucose Levels in Hypertensive and Obese Patients with Insulin Resistance

Suliburska

Bogdański

Pupek-Musialik

et al. 2010

Biol Trace Elem Res

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Inadequate minerals intake, as well as disruption of some metabolic processes in which microelements are cofactors, are suggested to lead to the development of hypertension. The role of minerals in the pathogenesis of hypertension still remains to be explained. In the present study, we sought to determine associations between serum and hair mineral concentrations and serum lipids and glucose levels. Forty obese hypertensive subjects with insulin resistance and 40 healthy volunteers were recruited in the study. Blood pressure, BMI, and insulin resistance were recorded in all subjects. Levels of lipids, glucose, sodium and potassium, iron, copper, zinc, magnesium, and calcium were assessed in serum. Iron, copper, zinc, magnesium, and calcium were assessed in hair. Dietary intake of the analyzed minerals was estimated. We found distinctly higher concentrations of serum iron and serum and hair calcium as well as markedly lower levels of hair zinc in the hypertensive subjects. The study group manifested also significantly lower daily intake of calcium, magnesium, and iron. We observed a relationship between the concentrations of iron, zinc, and copper in serum and hair and high and low range of cholesterol, triglycerides, and glucose serum levels in the studied patients. Moreover, this study demonstrated significant correlation between serum and hair concentrations of selected minerals and their dietary intake and levels of serum lipids and glucose and blood pressure in the study and the control groups. The obtained results seem to indicate the association between lipid and glucose metabolism and iron, copper, zinc, and calcium concentrations in blood and hair of hypertensive and obese patients with insulin resistance.

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Section: Discussionmentioning

confidence: 97%

Dietary Intake and Serum and Hair Concentrations of Minerals and their Relationship with Serum Lipids and Glucose Levels in Hypertensive and Obese Patients with Insulin Resistance

Suliburska

Bogdański

Pupek-Musialik

et al. 2010

Biol Trace Elem Res

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“…Defective Cu metabolism is said to impair cardiovascular health in at least two known settings, chronic Cu deficiency (9,10) and defective intracellular Cu transport to mitochondrial cytochrome C oxidase caused by missense mutations in the second cytochrome c oxidase assembly gene, SCO2 (11). Thus, Cu deficiency has been implicated as a defect of Cu homeostasis that can lead to cardiac disease (12).…”

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confidence: 99%

Regeneration of the Heart in Diabetes by Selective Copper Chelation

et al. 2004

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Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Although altered systemic regulation of transition metals in diabetes has been the subject of previous investigation, it is not known whether changed transition metal metabolism results in heart disease in common forms of diabetes and whether metal chelation can reverse the condition. We found that administration of the Cu-selective transition metal chelator trientine to rats with streptozotocin-induced diabetes caused increased urinary Cu excretion compared with matched controls. A Cu II -trientine complex was demonstrated in the urine of treated rats. In diabetic animals with established heart failure, we show here for the first time that 7 weeks of oral trientine therapy significantly alleviated heart failure without lowering blood glucose, substantially improved cardiomyocyte structure, and reversed elevations in left ventricular collagen and ␤ 1 integrin. Oral trientine treatment also caused elevated Cu excretion in humans with type 2 diabetes, in whom 6 months of treatment caused elevated left ventricular mass to decline significantly toward normal. These data implicate accumulation of elevated loosely bound Cu in the mechanism of cardiac damage in diabetes and support the use of selective Cu chelation in the treatment of this condition.

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“…In addition, copper deficiency can cause myelopathy (9), and inflammatory lung disease by neutrophil-endothelial interactions (15); it also may impair cardiovascular health (16,17). Since most patients in our study were bedridden for long term duration with severe difficulty in communication and mobilization, they could not present symptoms and signs of clinical myelopathy associated with copper deficiency; we did not perform magnetic resonance imaging and somatosensory evoked potential analysis to identify occult myelopathy (9).…”

Section: Methodsmentioning

confidence: 99%