Cardiovascular Effects of Exercise Training

Gielen, Stephan; Schuler, Gerhard; Adams, Volker

doi:10.1161/circulationaha.110.939959

Cited by 387 publications

(323 citation statements)

References 225 publications

(217 reference statements)

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“…NO also appears to be of minor importance in regard to the vasorelaxation of small arterioles with diameters <100 μm, because these vessels are primarily regulated by myogenic factors 41, 42…”

Section: Adaptation Of Coronary Circulation To Exercise Training In Tmentioning

confidence: 99%

“…The discovery of bone marrow–derived CPC contributing to new vessels in a process known as vasculogenesis made the picture of exercise‐induced adaptations even more complex 49, 50, 51. The activation of matrix metalloproteinases 2 and 9 by NO enhances the mobility of CPCs in the bone marrow, resulting in the liberation of these cells into the circulation 42, 52, 53. Furthermore, the number and functional capacity of circulating CPCs seem to depend on NO bioavailibility 53, 54, 55.…”

Section: Adaptation Of Coronary Circulation To Exercise Training In Tmentioning

confidence: 99%

“…Modulation of the autonomic nervous system with diminished sympathetic tone, increased vagal activity, and augmented baroreflex sensitivity in response to exercise training was identified as an underlying mechanism in animals and patients 73, 74. Restoration of autonomic balance in combination with improved peripheral endothelial function and decreased blood pressure reduces cardiac afterload and improves left ventricular diastolic function 42, 75, 76. Exercise training was shown to induce reverse cardiac remodeling in patients with heart failure with reduced left ventricular ejection fraction 75, 77.…”

Section: Adaptation Of the Heart And The Vasculature In Response To Ementioning

confidence: 99%

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Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Winzer

Woitek

Linke

2018

JAHA

178

120

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Section: Adaptation Of Coronary Circulation To Exercise Training In Tmentioning

confidence: 99%

Section: Adaptation Of Coronary Circulation To Exercise Training In Tmentioning

confidence: 99%

Section: Adaptation Of the Heart And The Vasculature In Response To Ementioning

confidence: 99%

See 1 more Smart Citation

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Winzer

Woitek

Linke

2018

JAHA

178

120

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“…EX is known to stimulate endothelial NOS activity and the expression of antioxidant enzymes [27,58]. Yet, EX is also known to transiently increase oxidative stress, and the beneficial adaptive changes can be prevented by a concomitant intake of antioxidants [29,63].…”

Section: Ex Facilitates Adaptationmentioning

confidence: 99%

Postnatal exposure to voluntary exercise but not the antioxidant catechin protects the vasculature after a switch to an atherogenic environment in middle-age mice

Leblond

Nguyen

Bolduc

et al. 2013

Pflugers Arch - Eur J Physiol

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We aimed to evaluate the lasting functional imprinting of exercise (EX) and catechin (CAT) on the vascular function of middle-age mice switched to a proatherogenic environment. C57BL/6J mice (n=10-15 in each group) fed a regular diet (RD) were exposed from the age of 1 to 9 months either to EX (voluntary running; 2.7± 0.2 km/day), to the polyphenol CAT (30 mg/kg/day in drinking water), or to physical inactivity (PI). At 9 months of age, EX and CAT were stopped and mice either remained on the RD or were fed a Western diet (WD) for an additional 3 months. At 12 months of age, mice from all groups fed a WD had similar body mass, systolic blood pressure, and plasma total cholesterol, glucose, insulin, and isoprostane. Compared to the RD, the WD induced an indomethacin-sensitive aortic endothelium-dependent and independent dysfunction in PI mice (p<0.05) that was prevented by both EX and CAT; this benefit was associated with a higher (p< 0.05) non-nitric oxide/non-prostacyclin endothelium-dependent relaxation. While EX, but not PI or CAT, prevented vascular dysfunction induced by the WD in cerebral arteries, it had no effect in femoral arteries. The profiles of activity of antioxidant enzymes and of proinflammatory gene expression in the aorta suggest a better adaptation of EX>CAT>PI mice to stress. In conclusion, our data suggest that a postnatal exposure to EX, but not to CAT, imprints an adaptive defense capacity in the vasculature against a deleterious change in lifestyle.Correspondence to: Eric Thorin.eric.thorin@umontreal.ca. Electronic supplementary material The online version of this article

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“…The primary stimulus for cardiac hypertrophy is mechanical stress, which induces a growth response in the overloaded myocardium [4,5]. The mechanical loading regulates intracellular signals of specific gene expression for myocardial hypertrophy with participation of both endocrine and paracrine factors [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Cardiac hypertrophy and IGF-1 response to testosterone propionate treatment in trained male rats

Żebrowska¹,

Sadowska-Krępa²,

Jagsz³

et al. 2017

Open Life Sciences

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Abstract:Objective: Several studies have suggested that testosterone exerts a growth-promoting effect in the heart. Limited data are available regarding interactions between possible endocrine/paracrine effects in response to exercise training. Therefore, we examined supraphysiological testosterone-induced heart hypertrophy and cardiac insulin-like growth factor (IGF)-1 content in sedentary and exercise-trained rats. Design: Male Wistar rats (n=33) were randomly allocated to groups with a 6-week endurance training with or without testosterone, and sedentary animals with or without testosterone. The hormone (20 mg/250 g body weight was administrated once a week for six weeks. After six weeks the animals were anesthetized, euthanized and the heart was excised and weighed. The left ventricle was separated for biochemical analyses. Results: Testosterone-treated animals showed significantly higher cardiac IGF-1 content compared to untreated control and trained groups (p=0.01). The administration of supraphysiological testosterone significantly increased the heart weight to body weight ratio (HW/BW, p<0.01). A significant positive correlation was seen between IGF-1 levels and the HW/BW ratio (p=0.002; r=0.50) and between serum total testosterone levels and HW/BW (p=0.000; r=0.79). Conclusions:The results demonstrate that increased

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Cardiovascular Effects of Exercise Training

Cited by 387 publications

References 225 publications

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Postnatal exposure to voluntary exercise but not the antioxidant catechin protects the vasculature after a switch to an atherogenic environment in middle-age mice

Cardiac hypertrophy and IGF-1 response to testosterone propionate treatment in trained male rats

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