Cardiovascular effects of long-term caffeine administration in aged rats

Agaty, Sahar M El; Seif, Ansam Aly

doi:10.1007/s11845-014-1098-z

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…In the present study, the MDA concentration after administration of caffeine to diabetic rats was lower both in the lens and serum, as compared with the control diabetic animals. This observation is consistent with that made in old rats (18–20 months), in which caffeine administered at 25 mg/kg for 6 weeks reduced the MDA concentration in the serum [11].…”

Section: Discussionsupporting

confidence: 92%

“…Caffeine has been reported as a protective substance against cellular damage with beneficial antioxidant effects [8–10]. Intake of caffeine is associated with reduced levels of biomarkers of oxidative stress [11–15]. Caffeine is able to scavenge ROS, particularly the hydroxyl radical, known to be generated in the body by exposure to ultraviolet light and by many physiologic reactions involving oxygen utilization [16, 17].…”

Section: Introductionmentioning

confidence: 99%

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Effect of caffeine on biomarkers of oxidative stress in lenses of rats with streptozotocin-induced diabetes

Kaczmarczyk-Sedlak¹,

Folwarczna²,

Sedlak³

et al. 2019

aoms

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Introduction One of the major causes of cataract in diabetes is oxidative stress induced by reactive oxygen species (ROS). Nowadays, new substances with antioxidative properties that may prevent cataract development are needed. One such substance is caffeine – an alkaloid with well-documented antioxidative activity. Material and methods The study was conducted on lenses obtained from female rats, divided into 3 groups: control rats; diabetic rats; diabetic rats treated with caffeine at a dose of 20 mg/kg p.o. Type 1 diabetes was induced by streptozotocin (60 mg/kg i.p. ). After 4 weeks of caffeine administration, the rats were sacrificed, and the lenses were collected, weighed and homogenized in PBS. The homogenate was used for analysis of protein content, glutathione (GSH) concentration, advanced oxidation protein product (AOPP) concentration, malondialdehyde (MDA) concentration and the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Results The SOD, CAT and GPx activities were found to be higher in the lenses of diabetic rats. There were also increased MDA and AOPP concentrations as well as decreased GSH concentration. The administration of caffeine resulted in decreased activity of SOD, CAT and GPx. The treatment with caffeine also caused an increase of GSH concentration and a decrease of MDA and AOPP concentrations. Conclusions The results of the present study may be of relevance in determining the effect of caffeine on the processes induced by ROS in vivo . Further, they can be an indication for clinical observations aiming at the assessment of both preventive and therapeutic effects of caffeine in cataract.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of caffeine on biomarkers of oxidative stress in lenses of rats with streptozotocin-induced diabetes

Kaczmarczyk-Sedlak¹,

Folwarczna²,

Sedlak³

et al. 2019

aoms

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“…The acute effects of caffeinated beverages on electrocardiographic parameters were evaluated in various studies 7,8,19 . Most of them reported that PR interval and QRS complex were not changed after caffeinated beverage consumption 19,23,41 . This was consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Genç yetişkinlerde elektrofizyolojik ve hemodinamik parametreler üzerine kafeinli içeceklerin akut etkileri

ÇALIŞKAN

Bilgin

2022

Cukurova Medical Journal

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Purpose: The consumption of caffeinated beverages has significantly increased among young people in recent years. The objective of the study is to investigate the acute effects of caffeinated beverages on electrocardiographic and hemodynamic parameters of young adults. Materials and Methods: Study was designed as a non-randomized, non-placebo controlled, three-arm parallel assignment. It was conducted on 56 individuals selected from a pool of students enrolled at Aydın Adnan Menderes University. Energy drink, coffee, cola and control groups were determined according to the results of the applicant acceptance questionnaire. Blood pressure and electrocardiogram were measured before and after consuming the drinks at 30 minutes and 60 minutes. Heart rate variability was detected from electrocardiogram signal and investigated by linear analysis. Results: All caffeinated drinks increased the blood pressure. Only, heart rate was increased by energy drink and cola. There was a small increment in root-mean square differences of successive R-R intervals and the number of times successive heartbeat intervals exceed 50ms (NN50) values in coffee group. High frequency (HF) values were increased some for coffee and cola groups. But, low frequency (LF) and LF/HF values were decreased. These alterations were statistically significant for coffee group. PR interval and QRS complex did not alter, however, QTc interval was lower in energy drink and cola groups. Conclusion: Caffeinated beverage consumption has the potential to induce adverse effects on cardiovascular system of young adults. Coffee appears to be more prominent than energy drink and cola.

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Caffeine and cardiovascular diseases: critical review of current research

et al. 2016

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Caffeine is a most widely consumed physiological stimulant worldwide, which is consumed via natural sources, such as coffee and tea, and now marketed sources such as energy drinks and other dietary supplements. This wide use has led to concerns regarding the safety of caffeine and its proposed beneficial role in alertness, performance and energy expenditure and side effects in the cardiovascular system. The question remains "Which dose is safe?", as the population does not appear to adhere to the strict guidelines listed on caffeine consumption. Studies in humans and animal models yield controversial results, which can be explained by population, type and dose of caffeine and low statistical power. This review will focus on comprehensive and critical review of the current literature and provide an avenue for further study.

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Cardiovascular effects of long-term caffeine administration in aged rats

Abstract: Long-term caffeine administration in aged rats increased cardiac inotropy, lusitropy and preserved NO level, which points to a promising potential favorable effect on cardiac intrinsic properties.

Cited by 8 publications

References 39 publications

Effect of caffeine on biomarkers of oxidative stress in lenses of rats with streptozotocin-induced diabetes

Effect of caffeine on biomarkers of oxidative stress in lenses of rats with streptozotocin-induced diabetes

Genç yetişkinlerde elektrofizyolojik ve hemodinamik parametreler üzerine kafeinli içeceklerin akut etkileri

Caffeine and cardiovascular diseases: critical review of current research

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