2021
DOI: 10.1016/j.amjmed.2020.09.015
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Cardiovascular Effects of Medical Marijuana: A Systematic Review

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Cited by 12 publications
(6 citation statements)
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“…[9] The mechanism of regular cannabis use, as a risk factor for myocardial infarction and ischaemic stroke, may be due to the sympathomimetic effect of the 9-tetrahydrocannabinol component (THC). [10] THC affects CB1 receptors within the cardiovascular system, leading to haemodynamic changes: increase in blood pressure, vasodilation, alteration of coronary blood flow and tachycardia. These changes may predispose to ischaemia.…”
Section: Discussionmentioning
confidence: 99%
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“…[9] The mechanism of regular cannabis use, as a risk factor for myocardial infarction and ischaemic stroke, may be due to the sympathomimetic effect of the 9-tetrahydrocannabinol component (THC). [10] THC affects CB1 receptors within the cardiovascular system, leading to haemodynamic changes: increase in blood pressure, vasodilation, alteration of coronary blood flow and tachycardia. These changes may predispose to ischaemia.…”
Section: Discussionmentioning
confidence: 99%
“…These changes may predispose to ischaemia. [10,11] Similarly, increased vascular tone leads to reduced cerebral blood flow, which may be associated with increased risk of stroke. [11] Research is ongoing into both the potential pro-thrombotic effect of cannabis and the inflammatory potential of cannabis to contribute to the development of atheroma (both mediated via CB1 and CB2 receptors).…”
Section: Discussionmentioning
confidence: 99%
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“…dizziness, dry mouth and nausea; Briscoe & Casarett, 2018) and long‐term physical effects (e.g. cardiovascular rhythm abnormalities; Pasha et al, 2021). Short‐term cognitive deficits were also reported following MC treatment, including impaired executive function and short‐term memory (Saulino et al, 2021).…”
Section: Introductionmentioning
confidence: 99%
“…Cannabis has been linked to serious CV events, including myocardial infarction, stroke, cardiomyopathies, atherosclerosis and cardiac arrhythmias [15][16][17][18][19][20][21]. Although the exact mechanisms by which cannabis use may induce CVD events are unknown, it appears to be through activation of the endogenous cannabinoid system, consisting of endocannabinoids, their receptors and complex downstream signaling pathways [18,[22][23][24][25]. When cannabinoids enter systemic circulation they activate G-protein-coupled cannabinoid receptors-CB1 and CB2 [17]-which trigger several downstream effects, such as tachycardia, vasoconstriction, platelet aggregation, vascular inflammation and cardiac myocyte changes, among others [26,27].…”
Section: Introductionmentioning
confidence: 99%