The disparity in life expectancy between Indigenous and non-Indigenous populations is being driven by a heightened incidence of cardio-metabolic diseases, and is at least partly underpinned by educational, economic and historical determinants. However, there is a lack of consensus with regards to priorities for tackling these determinants. Therefore, the current study recruited experts in Indigenous cardio-metabolic health from Australia, New Zealand and the United States, in order to establish local consensus opinion and initiate dialogue. A three-round Delphi process was used to consolidate and compare the opinions of 60 experts, 20 from each country. Round one, the experts were asked three open-ended questions: (i) historical, (ii) economic and (iii) socio-cultural factors contributors to cardio-metabolic disease risk. Round two, the experts completed a structured questionnaire based on results from the first round, in which they ranked items according to their importance. Final round, the experts were asked to re-rank the same items after receiving summary feedback about the rank ordering from the previous round. Several key findings were identified: (i) an important historical factor is marginalization and disempowerment; (ii) in terms of economic and sociocultural factors, the panellists came to the consensus that socio-economic status and educational inequalities are important; (iii) while consensus was not reached, economic and educational factors also perceived to be historically influential. These findings support the need for multi-level health promotion policy. For example, tackling financial barriers that limit access to health-promoting resources, and improving literacy skills to permit understanding of health education.