Cardiovascular Magnetic Resonance, Fibrosis, and Prognosis in Dilated Cardiomyopathy

Assomull, Ravi; Prasad, Sanjay; Lyne, Jonathan; Smith, Gillian; Burman, Elizabeth; Khan, M. Gabriel; Sheppard, Mary N.; Poole‐Wilson, Philip A.; Pennell, Dudley J.

doi:10.1016/j.jacc.2006.07.049

Cited by 1,039 publications

(828 citation statements)

References 49 publications

Supporting

Mentioning

771

Contrasting

Unclassified

Order By: Relevance

“…Of these, 21 were excluded because they did not meet inclusion criteria. Three were excluded [1][2][3] because their data were included in more recent publications. [4][5][6] A total of 29 studies were finally included in the metaanalysis ( Figure 1).…”

Section: Search Results and Study Selectionmentioning

confidence: 99%

Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy

Marco

Anguera

Schmitt³

et al. 2017

JACC: Heart Failure

307

188

View full text Add to dashboard Cite

Di Marco, A. et al. (2017) Late gadolinium enhancement and the risk for ventricular arrhythmias or sudden death in dilated cardiomyopathy: systematic review and meta-analysis. JACC: Heart Failure, 5(1), pp. 28-38. (doi:10.1016/j.jchf.2016.09.017) This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/133553/ Background: Risk stratification for SCD in DCM needs to be improved.

show abstract

Section: Search Results and Study Selectionmentioning

confidence: 99%

Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy

Marco

Anguera

Schmitt³

et al. 2017

JACC: Heart Failure

307

188

View full text Add to dashboard Cite

show abstract

“…Computed tomography (CT) and cardiac magnetic resonance imaging (CMRI), especially with an LGE, can localize the regions of fibrosis or scarring (Figure 2). 10, 12, 13 The distribution and extent of the scar are useful for deciding the ablation strategy, such as an epicardial approach, transcoronary venous ablation, alcohol ablation, or simultaneous bipolar ablation. The integration of the reconstructed images obtained from CT, MRI, and 3D navigation mapping systems can aid in the illustration of the structural complexity and avoidance of damage to the critical regions, in terms of vascular or nervous structures (Figure 3).…”

Section: Management Of Vt In Nicmmentioning

confidence: 99%

“…These abnormal substrates frequently harbor fibrotic and scar tissue that lead to slow conduction and fractionated electrograms in human tissue experiments 54. Aside from the electroanatomic mapping, CMRI can help to delineate the scar distribution as well 10, 12, 13…”

Section: Management Of Vt In Nicmmentioning

confidence: 99%

Ventricular arrhythmias in nonischemic cardiomyopathy

Chung

Lin

et al. 2018

Journal of Arrhythmia

View full text Add to dashboard Cite

Nonischemic cardiomyopathies (NICMs) are composed of variable disease entities, including primary and secondary cardiomyopathies. Determining the etiology of NICM provides pivotal roles of not only the understanding of the individual pathogenesis, but also the clinical management, such as risk stratification, pharmacological treatment, and intervention therapies. Despite the diverse causes of NICM, these cases mostly require clinical attention owing to progressive myocardial injury, resulting in ventricular dysfunction and heart failure. The interaction between the diseased ventricular substrates and systemic/neurophysiological factors contributes to the cornerstones responsible for ventricular arrhythmogenesis and sudden cardiac death (SCD). Prevention of SCD and diminishing ventricular tachyarrhythmias are the important mainstays for the management of NICM patients. Given the understanding of the abnormal ventricular substrates and advancement of navigation systems, radiofrequency catheter ablation (RFCA) has become an adjunctive or alternative strategy for NICM patients who experience drug‐refractory ventricular tachycardias (VTs). Successful ablation can frequently be achieved at the expense of an epicardial intervention. A recent study has proven the survival benefits for NICM patients who are free from recurrent VTs after a successful RFCA, regardless of the New York Heart Association (NYHA) functional class status or left ventricular ejection fraction. Additionally, recent evidence has highlighted the better delineation of a diseased myocardium through the incorporation of cardiovascular magnetic resonance imaging (CMRI) and 3D mapping systems, which can facilitate the identification of critical ventricular arrhythmogenic substrates in NICM patients.

show abstract

“…As in HCM, CMR plays a major role in the diagnosis of DCM due to the previously addressed possibility of tissue characterization. LGE imaging can assess focal myocardial fibrosis and its presence has also recently been identified as a predictor of cardiac death in DCM [52]. On the other hand the quantification of fibrosis achieved by LGE has several limitations as mentioned in the HCM section, and mapping seems to be also approach in DCM.…”

Section: Dilated Cardiomyopathy (Dcm)mentioning

confidence: 99%

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Roller¹,

Harth²,

Schneider³

et al. 2015

Fortschr Röntgenstr

View full text Add to dashboard Cite

!Cardiac magnetic resonance imaging (CMRI) is a versatile diagnostic tool. One of its main advantages is the possibility of tissue characterization. T1-weighted images for scar and T2-weighted images for edema visualization are key methods for tissue characterization. Otherwise these sequences are strongly limited for the detection of diffuse myocardial pathologies. Recently, rapid technical innovations have generated new techniques. T1, T2 mapping and evaluation of the extracellular volume fraction (ECV) allow quantification of diffuse myocardial pathologies and showed great potential in the visualization of fibrosis, edema, amyloid, iron overload and lipid. In the future these techniques might enable the detection of early cardiac involvement, even act as a prognosticator. Moreover, therapy monitoring and follow-up might be possible due to versatile parameter quantification with these new techniques. Key points:▶ CMR allows for tissue characterization via T1-and T2-weighted sequences.▶ In cases of diffuse, global myocardial pathologies, correct image interpretation with traditional CMR sequences might be difficult.▶ T1, T2 mapping and ECV can quantify diffuse, global myocardial pathologies.

show abstract

Cardiovascular Magnetic Resonance, Fibrosis, and Prognosis in Dilated Cardiomyopathy

Cited by 1,039 publications

References 49 publications

Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy

Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy

Ventricular arrhythmias in nonischemic cardiomyopathy

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Contact Info

Product

Resources

About