Cardiovascular, respiratory, electrolyte and acid–base balance during continuous dexmedetomidine infusion in anesthetized dogs

Congdon, Jonathan; Marquez, Megan; Niyom, Sirirat; Boscán, Pedro

doi:10.1111/vaa.12036

Cited by 25 publications

(22 citation statements)

References 22 publications

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“…In the present study, the mean values obtained were over 96% for all animals. However, as well in the findings of this study, other studies indicate that respiratory alterations presented by the same drugs were not harmful and did not cause an impact in the respiratory function of the patients evaluated …”

Section: Discussionsupporting

confidence: 85%

“…However, as well in the findings of this study, other studies indicate that respiratory alterations presented by the same drugs were not harmful and did not cause an impact in the respiratory function of the patients evaluated. 33,34 In the present study, despite using a thermal blanket to maintain the body temperature, there was a significant reduction in the longterm values in groups SKD and KD, but the maximum difference seen between the base values and the lowest value was not over 0.9°C.…”

Section: Discussioncontrasting

confidence: 54%

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Evaluation of three chemical immobilization protocols in golden‐headed lion tamarins (Leontopithecus chrysomelas) undergoing vasectomy surgery

Ferraro

Molina

Catão‐Dias

et al. 2017

J of Medical Primatology

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Heart rate, sedation and muscle relaxation degrees, antinociception, and lidocaine consumption presented significant difference between midazolam and dexmedetomidine groups. Bradycardia was present on dexmedetomidine groups, with values remaining within the normal range. Dexmedetomidine groups present the best outcomes for muscle relaxation, sedation, and antinociception and were safe for vasectomy surgery in golden-headed lion tamarins.

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Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 54%

Evaluation of three chemical immobilization protocols in golden‐headed lion tamarins (Leontopithecus chrysomelas) undergoing vasectomy surgery

Ferraro

Molina

Catão‐Dias

et al. 2017

J of Medical Primatology

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show abstract

“…Based on previous studies of the cardiovascular effects of dexmedetomidine (Congdon et al. ), it is likely that its administration (DEX and LKD groups) increased systemic vascular resistance that would have countered the isoflurane‐induced vasodilation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the isoflurane‐sparing effects of fentanyl, lidocaine, ketamine, dexmedetomidine, or the combination lidocaine‐ketamine‐dexmedetomidine during ovariohysterectomy in dogs

Gutiérrez‐Blanco

Victoria-Mora

Ibancovichi-Camarillo

et al. 2013

Veterinary Anaesthesia and Analgesia

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“…The cardiovascular effects of alpha-2 agents have been well documented in dogs and cats with bradycardia being the most documented feature in cats. 9,11,27,[31][32][33][34][35][36][37] The decrease in heart rate is thought to be due to two known mechanisms associated with dexmedetomidine: a decrease in norepinephrine release in the central nervous system leading to a decrease in sympathetic tone, or a baroreceptor-mediated increase in vagal tone from an increase in arterial blood pressure inducing a bradycardia. 38,39 Cats in the current study that were administered dexmedetomidine were found to have significant decreases in their heart rates at 1, 2, 3, 5, and 6 hours post administration.…”

Section: Discussionmentioning

confidence: 99%

Assessment of hydromorphone and dexmedetomidine for emesis induction in cats

Nystrom

Odunayo

Okafor

2019

J Vet Emergen Crit Care

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Objective To compare the efficacy of hydromorphone and dexmedetomidine at inducing emesis in cats. Design Prospective, blinded, randomized crossover study. Setting Veterinary university teaching hospital. Animals 12 healthy purpose‐bred cats. Interventions Cats were randomly assigned to receive hydromorphone (0.1 mg/kg, subcutaneously) or dexmedetomidine (7 μg/kg, IM). Following administration, the incidences of emesis, number of emetic events, signs of nausea (hypersalivation, lip licking), temperature, heart rate, respiratory rate, and sedation score were recorded for 6 hours. Measurements and Main Results Emesis was successful in 9 of 12 (75%) cats when treated with hydromorphone and in 7 of 12 (58%) cats when treated with dexmedetomidine (P = 0.67). Dexmedetomidine was more likely to cause sedation than hydromorphone (P < 0.001). Heart rate in cats was significantly decreased at 1 and 2 hours post‐hydromorphone (P = 0.003, 0.014, respectively) and at 1, 2, 3, 5, 6 hours post‐dexmedetomidine (P = 0.001, 0.003, 0.038, 0.013, 0.001, respectively). Cats were more likely to develop an increase in body temperature with hydromorphone administration although this was not clinically significant. Conclusions Results of the present study indicate that hydromorphone is an effective alternative to dexmedetomidine for the induction of emesis in cats. Hydromorphone appears to cause less sedation and less decrease in heart rate. Further investigation into the most adequate dose of hydromorphone for optimizing emesis is warranted.

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Cardiovascular, respiratory, electrolyte and acid–base balance during continuous dexmedetomidine infusion in anesthetized dogs

Cited by 25 publications

References 22 publications

Evaluation of three chemical immobilization protocols in golden‐headed lion tamarins (Leontopithecus chrysomelas) undergoing vasectomy surgery

Evaluation of three chemical immobilization protocols in golden‐headed lion tamarins (Leontopithecus chrysomelas) undergoing vasectomy surgery

Evaluation of the isoflurane‐sparing effects of fentanyl, lidocaine, ketamine, dexmedetomidine, or the combination lidocaine‐ketamine‐dexmedetomidine during ovariohysterectomy in dogs

Assessment of hydromorphone and dexmedetomidine for emesis induction in cats

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