Cardiovascular Responses to Metabolic Acidosis

Downing, S. E.; Talner, Norman S.; Gardner, Thomas H.

doi:10.1097/00132586-196512000-00027

Cited by 10 publications

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“…These results are in agreement with the effects brought about on the heart and circulation by the reduction of osmolality and potassium and by the increase of pH. while hematocrit and plasma protein remain constant [29][30][31], Therefore, it is only during dialysis and not during ultrafiltration that myocardial contractility improves. These results do not confirm the opinions of several authors about the existence of a 'uremic cardiomyopathy' [32][33][34].…”

Section: Discussionsupporting

confidence: 87%

Echocardiographic Hemodynamic Study during Ultrafiltration Sequential Dialysis

Cini¹,

Camici²,

Pentimone³

et al. 1982

Nephron

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4 patients on regular dialysis were studied by the echocardiographic method during ultrafiltration and dialysis performed sequentially according to two different protocols. Blood pressure, heart rate, cardiac output, stroke volume, systolic and diastolic dimension of the left ventricle, systolic and diastolic volumes of the left ventricle, ejection fraction, shortening fraction and total peripheral vascular resistance index were measured. During ultrafiltration there is an increase of the total peripheral vascular resistance index. Myocardial contractility improves only during dialysis. Physiopathologic implications are discussed.

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Section: Discussionsupporting

confidence: 87%

Echocardiographic Hemodynamic Study during Ultrafiltration Sequential Dialysis

Cini¹,

Camici²,

Pentimone³

et al. 1982

Nephron

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“…in the rabbit auricle, Andrus, 1924; in the cat, Burget & Visscher, 1927;and in man, Campbell, Houle, Crisp, Weil & Brown, 1958), but Downing, Talner & Gardner (1965a) found no evidence of a diminished positive inotropic response of the left ventricle of the cat to an infusion of noradrenaline during acidaemia. It has also been suggested that the response to stimulation of the vagal nerves is increased R. J. LINDEN AND J. NORMAN during acidaemia (Campbell, 1955).…”

Section: Introductionmentioning

confidence: 96%

The effect of acidaemia on the response to stimulation of the autonomic nerves to the heart

Norman¹

1969

The Journal of Physiology

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SUMMARY1. The effects are described of an acidaemia produced either by an inhalation of carbon dioxide or by an infusion of hydrochloric acid on the response of the heart to stimulation of the ansae subclaviae and right vagus nerve in anaesthetized dogs.2. The results show that during an acidaemia (pH 6.95) of up to 2 hr duration the response to stimulation of the right vagus nerve was enhanced and that the inotropic response to stimulation of sympathetic nerves was not changed; the chronotropic response was depressed during acidaemia only at the low end of the range of responses, from 0 to 40 beats/ min. The importance of preventing acidaemia when investigating reflex heart rate responses is discussed.3. It is suggested that in the intact animal with an innervated heart the response of the heart to stimulation of the sympathetic nerves is unaltered in acidaemia and that the reported effects of changed cardiovascular response during acidaemia may in part be explained by the enhanced response to vagal stimulation and an altered response of the peripheral vessels.

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“…In respiratory as well as in metabolic acidosis an increase of cardiac output (Carson et al, 1965;Andersen and Mouritzen, 1966;KShler et al, 1971), no significant alterations (Vaughan Williams, 1955;Downing et al, 1965) or even a decrease of cardiac output were observed (Nahas, 1957 ;Bendixen et al, 1963). In respiratory as well as in metabolic acidosis an increase of cardiac output (Carson et al, 1965;Andersen and Mouritzen, 1966;KShler et al, 1971), no significant alterations (Vaughan Williams, 1955;Downing et al, 1965) or even a decrease of cardiac output were observed (Nahas, 1957 ;Bendixen et al, 1963).…”

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confidence: 96%

Effect of respiratory acidosis on heart and circulation in cats, pigs, dogs and rabbits

et al. 1972

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In closed chest cats, dogs, rabbits and pigs, anaesthetized with pentobarbital and relaxed with diallylnortoxiferinium dichloride the effects of a respiratory acidosis on heart and circulation as well as their reaction to sympathomimetic amines were studied.1. In cats and pigs a respiratory acidosis causes a rise of frequency, dp/dtmax of the left ventricle and systolic blood-pressure. In rabbits an acidosis causes no significant alteration of blood-pressure and dp/dtmax. In dogs frequency, dp/dtmax and blood-pressure decline in acidosis. In cats pretreated with reserpine a respiratory acidosis causes a negative inotropic effect and a declining of blood-pressure. After pretreating cats with phenoxybenzamine in acidosis there results a decrease of bloodpressure, but a rise of dp/dtmax and frequency; after pretreating with pindolol in acidosis dp/dtmax and frequency decline, but blood-pressure remains unaltered. The e~eetiveness o/ sympathomimetic amines on heart and circulation is di-minished in acidosis. This diminution is most significant in those animMs (cat, pig) with the most augmented sympathetic tonus in acidosis, but experiments performed with reserpinized cats indicated that the augmented sympathetic tonus can not be the only cause for the diminished efficiency of adrenergic stimulant amines in acidosis.3. Biochemical studies performed in acidosis showed a rise of K +, Mg 2+, inorganic phosphate and glucose in serum and a decrease of Mg 2+ in the heart muscle.

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Cardiovascular Responses to Metabolic Acidosis

Cited by 10 publications

References 0 publications

Echocardiographic Hemodynamic Study during Ultrafiltration Sequential Dialysis

Echocardiographic Hemodynamic Study during Ultrafiltration Sequential Dialysis

The effect of acidaemia on the response to stimulation of the autonomic nerves to the heart

Effect of respiratory acidosis on heart and circulation in cats, pigs, dogs and rabbits

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