Cardiovascular risk and encoding-related hippocampal connectivity in older adults

Meusel, Liesel-Ann C.; Greenwood, Carol E.; Maione, Andrea; Tchistiakova, Ekaterina; MacIntosh, Bradley J.; Anderson, Nicole

doi:10.1186/s12868-019-0518-4

Cited by 7 publications

(6 citation statements)

References 47 publications

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“… 32 In fact, a recent functional magnetic resonance imaging study found cardiovascular risk to be associated with altered hippocampal-medial prefrontal coupling when completing a memory encoding task. 33 In line with this, we also found that WHx MI made more errors in placing items during the immediate trial of the RCFT. This could indicate subtle spatial memory impairments, in which WHx MI remember pieces of the figure, but spatial location of those pieces, which are thought to be highly governed by hippocampal place cells, seemed to be an issue.…”

Section: Discussionsupporting

confidence: 82%

Women with Myocardial Infarction Present Subtle Cognitive Difficulties on a Neuropsychological Battery After Exposure to a Social Stressor

Poitras¹,

Linares²,

Lambert³

et al. 2022

PRBM

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Objective Myocardial infarction (MI) is the primary cause of mortality and morbidity in women, but its sequelae remain largely understudied. Given the heart–brain relationship, our study aimed to further understand stress’s impact on regulating cognitive function post-MI. Specifically, our study evaluated the effect of stress induced using the Trier Social Stress Test (TSST), on neuropsychological function in women who have or have not experienced MI. Methodology To do so, women (mean age = 59.41 yrs) with (WHx MI = 13) or without ( ) a history of MI were exposed to the TSST prior to completion of a series of standardized neuropsychological tests: the Montreal Cognitive Assessment (MoCA), Control Oral Word Association (COWA), Rey Complex Figure and Recognition (RCFT), Trail Making Test (TMT), and Auditory Consonant Triagrams (ACT). Results Our findings support MI to be associated with impairments in working memory affecting immediate recall of ACT, as well as visuospatial impairments in the RCFT copy trial, marked by poorer drawing accuracy and incorrect placement of figure elements. Overall, WHx MI required more time to complete the neuropsychological assessment (WHx MI 166.57 ± 12, 155.00 ± 6.57; p < 0.01). Conclusion Together, these findings support cognitive impairments noted following a social stressor to remain subtle in WHx MI . Our study highlights the need for the development of more sensitive tools to screen for neuropsychological impairments in women with MI and the importance of assessing performance in a variety of testing conditions.

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Section: Discussionsupporting

confidence: 82%

Women with Myocardial Infarction Present Subtle Cognitive Difficulties on a Neuropsychological Battery After Exposure to a Social Stressor

Poitras¹,

Linares²,

Lambert³

et al. 2022

PRBM

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show abstract

“…The frontal lobe, cuneate lobe, anterior cuneate lobe, cingulate gyrus, hippocampus, and parahippocampal gyrus belong to the default mode network (DMN). Extensive studies have shown that the DMN is sensitive to nervous system diseases and can be destroyed in the early stage, which may also be one of the reasons for the decrease in cognitive function in patients with CSVD ( Meusel et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Dynamic alterations in the amplitude of low-frequency fluctuation in patients with cerebral small vessel disease

Song,

Lei,

et al. 2023

Front. Mol. Neurosci.

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Background and purposePrevious studies have focused on the changes of dynamic and static functional connections in cerebral small vessel disease (CSVD). However, the dynamic characteristics of local brain activity are poorly understood. The purpose of this study was to investigate the dynamic cerebral activity changes in patients with CSVD using the dynamic amplitude of low-frequency fluctuation (d-ALFF).MethodsA total of 104 CSVD patients with cognitive impairment (CSVD-CI, n = 52) or normal cognition (CSVD-NC, n = 52) and 63 matched healthy controls (HCs) were included in this study. Every participant underwent magnetic resonance imaging scans and a battery of neuropsychological examinations. The dynamics of spontaneous brain activity were assessed using dynamic changes in the amplitude of low-frequency fluctuation (ALFF) with the sliding-window method. We used voxel-wise one-way analysis of variance (ANOVA) to compare dynamic ALFF variability among the three groups. Post-hoc t-tests were used to evaluate differences between each group pair. Finally, the brain regions with d-ALFF values with differences between CSVD subgroups were taken as regions of interest (ROI), and the d-ALFF values corresponding to the ROI were extracted for partial correlation analysis with memory.Results(1) There was no significant difference in age (p = 0.120), sex (p = 0.673) and education (p = 0.067) among CSVD-CI, CSVD-NC and HC groups, but there were significant differences Prevalence of hypertension and diabetes mellitus among the three groups (p < 10−3). There were significant differences in scores of several neuropsychological scales among the three groups (p < 10−3). (2) ANOVA and post-hoc t-test showed that there were dynamic abnormalities of spontaneous activity in several brain regions in three groups, mainly located in bilateral parahippocampal gyrus and bilateral hippocampus, bilateral insular and frontal lobes, and the static activity abnormalities in bilateral parahippocampal gyrus and bilateral hippocampal regions were observed at the same time, suggesting that bilateral parahippocampal gyrus and bilateral hippocampus may be the key brain regions for cognitive impairment caused by CSVD. (3) The correlation showed that d-ALFF in the bilateral insular was slightly correlated with the Mini-Mental State Examination (MMSE) score and disease progression rate. The d-ALFF value of the left postcentral gyrus was negatively correlated with the Clock Drawing Test (CDT) score (r = −0.416, p = 0.004), and the d-ALFF value of the right postcentral gyrus was negatively correlated with the Rey’s Auditory Verbal Learning Test (RAVLT) word recognition (r = −0.320, p = 0.028).ConclusionThere is a wide range of dynamic abnormalities of spontaneous brain activity in patients with CSVD, in which the abnormalities of this activity in specific brain regions are related to memory and execution or emotion.

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“…27,28 For example, 1 study linked higher Framingham risk scores with smaller brain volumes in PWoH across the age spectrum. 27 Similarly, a study of 38 male PWH and 37 PWoH showed that elevated Framingham risk scores were associated with larger volume of white matter hyperintensities, a biomarker of cerebral small vessel disease. 28 Conversely, 1 study observed that CVD variables were not associated with gray matter or white matter brain volumes.…”

Section: Discussionmentioning

confidence: 99%

“…These results complement previous studies associating Framingham scores with changes in neuroimaging in PWH. 27,28 For example, 1 study linked higher Framingham risk scores with smaller brain volumes in PWoH across the age spectrum. 27 Similarly, a study of 38 male PWH and 37 PWoH showed that elevated Framingham risk scores were associated with larger volume of white matter hyperintensities, a biomarker of cerebral small vessel disease.…”

Section: Discussionmentioning

confidence: 99%

Effects of Framingham 10-Year Cardiovascular Risk Score and Viral Load on Brain Integrity in Persons With HIV

Glans

Cooley

Vaida

et al. 2022

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background: Combination antiretroviral therapy (cART) has allowed for viral load (VL) suppression and increased life expectancy for persons with HIV (PWH). Altered brain integrity, measured by neuropsychological (NP) performance and neuroimaging, is still prevalent among virally suppressed PWH. Age-related conditions such as cardiovascular disease may also affect brain integrity. This study investigated the effects of cardiovascular risk, VL, and HIV serostatus on cerebral blood flow (CBF), brain volumetrics, and cognitive function in PWH and persons without HIV (PWoH).Methods: Ten-year cardiovascular risk, using the Framingham Heart Study criteria, was calculated in PWH (n = 164) on cART with undetectable (#20 copies/mL; n = 134) or detectable (.20 copies/mL; n = 30) VL and PWoH (n = 66). The effects of cardiovascular risk on brain integrity (CBF, volume, and cognition) were compared for PWH (undetectable and detectable VL) and PWoH.Results: PWH had smaller brain volumes and worse NP scores than PWoH. PWH with detectable and undetectable VL had similar brain integrity measures. Higher cardiovascular risk was associated with smaller volumes and lower CBF in multiple brain regions for PWH and PWoH. Significant interactions between HIV serostatus and cardiovascular risk on brain volumes were observed in frontal, orbitofrontal, and motor regions. Cardiovascular risk was not associated with cognition for PWH or PWoH. Conclusions:Neuroimaging, but not cognitive measures, was associated with elevated cardiovascular risk. HIV serostatus was associated with diminished brain volumes and worse cognition while CBF remained unchanged, reflecting potential protective effects of cART. Neuroimaging measures of structure (volume) and function (CBF) may identify contributions of comorbidities, but future longitudinal studies are needed.

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Cardiovascular risk and encoding-related hippocampal connectivity in older adults

Cited by 7 publications

References 47 publications

Women with Myocardial Infarction Present Subtle Cognitive Difficulties on a Neuropsychological Battery After Exposure to a Social Stressor

Women with Myocardial Infarction Present Subtle Cognitive Difficulties on a Neuropsychological Battery After Exposure to a Social Stressor

Dynamic alterations in the amplitude of low-frequency fluctuation in patients with cerebral small vessel disease

Effects of Framingham 10-Year Cardiovascular Risk Score and Viral Load on Brain Integrity in Persons With HIV

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