Cardiovascular risk factors correlate with prostate size in men with bladder outlet obstruction

Abstract

tested. The measured variables were assessed statistically in relation to whether the prostate volume was smaller (22 men) or larger (30 men) than 50 mL. RESULTSPatients with a large prostate (mean 104 mL) had a higher mean arterial pressure (105 vs 95 mmHg, P < 0.01), and serum glucose (5.3 vs 4.8 mmol/L, P < 0.01) and serum cortisol (423 vs 362 nmol/L, P = 0.06) concentrations than those with a small gland (mean 31 mL). The personality test showed that they were also less assertive than the others ( P < 0.03). The components of the heart rate variability indicated that men with a large prostate had increased sympathetic activity. CONCLUSIONMen with LUTS caused by a very large prostate have more risk factors for cardiovascular disease than those with a smaller gland.

Are lower urinary tract symptoms associated with cardiovascular disease in the Dutch general population? Results from the Krimpen study

“…As CVD have a high incidence of morbidity and mortality, it is important to find patients at risk [3]. Previously, it has been suggested that LUTS are associated with CVD and may predict subsequent cardiovascular events [4][5][6][7][8][9].…”

“…Methods We performed post hoc analyses using data from the Krimpen study, a large community-based study in the Netherlands. All men aged 50-75 years, without prostate or bladder cancer, a history of radical prostatectomy, or This may be explained by the fact that LUTS and CVD share risk factors such as obesity, diabetes, hypertension, smoking, and aging [4][5][6][7][8][9]. These well-known vascular risk factors might also impact LUTS through various pathways from vascular diseases [4][5][6][7][8][9].…”

“…All men aged 50-75 years, without prostate or bladder cancer, a history of radical prostatectomy, or This may be explained by the fact that LUTS and CVD share risk factors such as obesity, diabetes, hypertension, smoking, and aging [4][5][6][7][8][9]. These well-known vascular risk factors might also impact LUTS through various pathways from vascular diseases [4][5][6][7][8][9]. However, the results of studies, describing the association between LUTS and CVD, are diverse and conflicting [4][5][6][7][8][9][10][11][12][13].…”

“…These well-known vascular risk factors might also impact LUTS through various pathways from vascular diseases [4][5][6][7][8][9]. However, the results of studies, describing the association between LUTS and CVD, are diverse and conflicting [4][5][6][7][8][9][10][11][12][13]. There are several small clinical studies of referred men at urologic clinics [4][5][6], analyzing multiple risk factors, sometimes without adequate standardization or without adjustment for age [5].…”

“…However, the results of studies, describing the association between LUTS and CVD, are diverse and conflicting [4][5][6][7][8][9][10][11][12][13]. There are several small clinical studies of referred men at urologic clinics [4][5][6], analyzing multiple risk factors, sometimes without adequate standardization or without adjustment for age [5]. As both CVD and LUTS are highly age related, the association between the two needs to be adjusted for age, or stratified analyses should be performed.…”