2009
DOI: 10.1111/j.1478-3231.2010.02274.x
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Cardiovascular risk factors following orthotopic liver transplantation: predisposing factors, incidence and management

Abstract: Background: Liver transplantation is the standard of care for acute and chronic causes of end-stage liver disease. Advances in medical therapy and surgical techniques have led to improvement of patient and graft survival rates following orthotopic liver transplantation. However, the prevalence of posttransplant cardiovascular complications has been rising with increased life expectancy after liver transplantation. Aims: To determine the incidences, risk factors, and treatment for hypertension, hyperlipidaemia,… Show more

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Cited by 77 publications
(44 citation statements)
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“…It is most important to predict cardiac outcomes in adult patients who are undergoing LT, because cardiovascular disease has been found to be one of the most common causes of complications, and even death, in LT patients with functional grafts, particularly in cases with preexisting cardiac histories. 13,48 Our data indicate that multivessel CAD, which is thought to be a powerful predictor of post-LT mortality, 37 may be more common in cirrhotic patients, despite the fact that the prevalence of obstructive lesions in the cirrhotic patients was equivalent to that in the noncirrhotic individuals. Furthermore, LC patients were also at higher risk of nonobstructive CAD with more unfavorable course than normal coronary arteries, especially in extensive disease, although it remains to be seen whether management of such patients might improve outcomes.…”
Section: Discussionmentioning
confidence: 71%
“…It is most important to predict cardiac outcomes in adult patients who are undergoing LT, because cardiovascular disease has been found to be one of the most common causes of complications, and even death, in LT patients with functional grafts, particularly in cases with preexisting cardiac histories. 13,48 Our data indicate that multivessel CAD, which is thought to be a powerful predictor of post-LT mortality, 37 may be more common in cirrhotic patients, despite the fact that the prevalence of obstructive lesions in the cirrhotic patients was equivalent to that in the noncirrhotic individuals. Furthermore, LC patients were also at higher risk of nonobstructive CAD with more unfavorable course than normal coronary arteries, especially in extensive disease, although it remains to be seen whether management of such patients might improve outcomes.…”
Section: Discussionmentioning
confidence: 71%
“…6 Several studies have determined the cumulative risk of CVD after LT. Independent predictive factors of CVD are older age at transplantation, male sex, preexisting cardiac disease, and components of the MS. [7][8][9] In addition, patients with underlying NASH cirrhosis have a significantly higher risk of CVD compared to other indications. The frequency of major intraoperative and postoperative cardiac complications was markedly increased in recipients with known heart disease compared to those without.…”
Section: See Article On Page 889mentioning
confidence: 99%
“…6 Several studies have determined the cumulative risk of CVD after LT. Independent predictive factors of CVD are older age at transplantation, male sex, preexisting cardiac disease, and components of the MS. [7][8][9] …”
mentioning
confidence: 99%
“…Concerning pharmacological measures, pancreatic lipase inhibitors like tetrahydrolipstatin (orlistat), which can be used in the general population with morbid obesity, present important interactions with the immunosuppressive agents, and thus have to be limited in the transplant population (Desai et al, 2010).…”
Section: Obesitymentioning
confidence: 99%
“…The survival of transplant patients who develop diabetes is lower than that for those without diabetes. In addition, these patients can present the same microvascular complications as in the general population, including retinopathy, nephropathy and infections (Desai et al, 2010).…”
Section: Diabetesmentioning
confidence: 99%