Cardiovascular risk, fatty liver disease, glucose and insulin curve among prediabetes phenotypes in Peruvian population

Rocca, Jesus; Calderón, María

doi:10.1016/j.ajmo.2022.100007

Cited by 1 publication

(1 citation statement)

References 38 publications

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“…Others suggest that HbA1cdefined prediabetes is associated with a defective insulin response in combination with inappropriate suppression of glucagon [53]. In the same way, epidemiological studies have attempted to identify phenotypes according to the different cut-off points on the OGTT [14,[54][55][56]. The Diabetes Research on Patient Stratification Study (DIRECT), a 48-month follow-up study, showed the profiles of glucose metabolism in different prediabetes phenotypes classified by FPG, 2 h OGTT, HbA1c, and 1 h-PG in the OGTT.…”

Section: Pathophysiology According To the Defect In Glycemic Controlmentioning

confidence: 99%

Prediabetes and Cardiometabolic Risk: The Need for Improved Diagnostic Strategies and Treatment to Prevent Diabetes and Cardiovascular Disease

Lizarzaburu-Robles,

Herman,

Garro-Mendiola

et al. 2024

Biomedicines

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The progression from prediabetes to type-2 diabetes depends on multiple pathophysiological, clinical, and epidemiological factors that generally overlap. Both insulin resistance and decreased insulin secretion are considered to be the main causes. The diagnosis and approach to the prediabetic patient are heterogeneous. There is no agreement on the diagnostic criteria to identify prediabetic subjects or the approach to those with insufficient responses to treatment, with respect to regression to normal glycemic values or the prevention of complications. The stratification of prediabetic patients, considering the indicators of impaired fasting glucose, impaired glucose tolerance, or HbA1c, can help to identify the sub-phenotypes of subjects at risk for T2DM. However, considering other associated risk factors, such as impaired lipid profiles, or risk scores, such as the Finnish Diabetes Risk Score, may improve classification. Nevertheless, we still do not have enough information regarding cardiovascular risk reduction. The sub-phenotyping of subjects with prediabetes may provide an opportunity to improve the screening and management of cardiometabolic risk in subjects with prediabetes.

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Section: Pathophysiology According To the Defect In Glycemic Controlmentioning

confidence: 99%

Prediabetes and Cardiometabolic Risk: The Need for Improved Diagnostic Strategies and Treatment to Prevent Diabetes and Cardiovascular Disease

Lizarzaburu-Robles,

Herman,

Garro-Mendiola

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

Cardiovascular risk, fatty liver disease, glucose and insulin curve among prediabetes phenotypes in Peruvian population

Cited by 1 publication

References 38 publications

Prediabetes and Cardiometabolic Risk: The Need for Improved Diagnostic Strategies and Treatment to Prevent Diabetes and Cardiovascular Disease

Prediabetes and Cardiometabolic Risk: The Need for Improved Diagnostic Strategies and Treatment to Prevent Diabetes and Cardiovascular Disease

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