Cardiovascular risk profile of young adults: Changes over time

Tralhão, António; Sousa, Pedro Jerónimo; Ferreira, António Miguel; Miranda, María Adelaide; Monge, José; Tomé, António; Cruz, José María Duarte

doi:10.1016/j.repce.2013.07.019

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…At the same time, overweight has also intensified among young people of different ages throughout the industrialized world (2) . There is already evidence of an increased prevalence of overweight in children and adolescents (3)(4)(5)(6)(7) . However, the population of young adult women has not been considered in the surveys with the same intensity.…”

Section: Introductionmentioning

confidence: 99%

Overweight and associated factors in young adult student girls

et al. 2018

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Objective: To analyze overweight and associated factors in young adult student girls children in a capital city of Northeast Brazil. Method: An analytical, quantitative study was conducted with 546 young adults from 26 schools in a capital city of the Brazilian Northeast. After obtaining the data by the application of a specific questionnaire, the hierarchical logistic regression was used to identify the confounding variables and predictors of overweight. Results: The frequency of cases of overweight in this group was 36.6%. In the bivariate analysis, Overweight presented a statistically significant association with ethnicity, marital status, weight in childhood and overweight in adolescence, overweight in the family and exposure to alcohol, number of children, and age of menarche. In the final regression model, overweight remained associated with weight in childhood and age of menarche. Conclusion: Characteristics related to nutritional status in earlier life stages and gynecological issues were associated with Overweight during the young adult stage of the woman.

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Section: Introductionmentioning

confidence: 99%

Overweight and associated factors in young adult student girls

et al. 2018

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“…In the general population, cardiovascular risk assessment is traditionally performed in adults by measuring a range of metabolic parameters in the circulation, including lipids and glucose as well as assessing clinical and environmental parameters such as hypertension, smoking, obesity and physical inactivity [18]. However, the low prevalence of these abnormalities in the young renders cardiovascular risk stratification challenging.…”

Section: Anthropometric Measurements Z-scores (Median [Iqr]mentioning

confidence: 99%

Body Fat Accumulation is Associated with Early Arterial Changes in HIVInfected Children

Charakida¹

2014

J AIDS Clin Res

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“…As a pathological basis of cardiovascular and cerebrovascular diseases, atherosclerosis (AS) is viewed as a chronic and progressive disease of the arterial wall ( 3 ). Emerging evidence has expounded that the prevalence of AS is escalating annually, and increasingly affecting younger people ( 4 ). At present, statins are widely applied to prevent the progression of AS and reduce cardiovascular events ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Sarsasapogenin blocks ox-LDL-stimulated vascular smooth muscle cell proliferation, migration, and invasion through suppressing STIM1 expression

Zhai¹,

Liu²,

Shang³

et al. 2023

Cardiovasc Diagn Ther

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Background Atherosclerosis (AS) is a pathological vascular disorder responsible for the majority of cardiovascular deaths. Sarsasapogenin (Sar) is a natural steroidal compound which has been extensively applied to multiple human diseases due to its pharmacological properties. In the present paper, the impacts of Sar on oxidized low-density lipoprotein (ox-LDL)-treated vascular smooth muscle cells (VSMCs) and its possible action mechanism were investigated. Methods Firstly, Cell Counting Kit-8 (CCK-8) estimated the viability of VSMCs following treatment with ascending doses of Sar. Then, VSMCs were treated by ox-LDL to stimulate an in vitro cell model of AS. CCK-8 and 5-Ethynyl-2’-deoxyuridine (EDU) assays were used to assess cell proliferation. Wound healing and transwell assays were applied to measure the migratory and invasive capacities, respectively. The expression of proliferation-, metastasis-, and stromal interaction molecule 1 (STIM1)/Orai signaling-associated proteins was measured by western blot. Results The experimental data illuminated that Sar treatment noticeably protected against ox-LDL-elicited VSMCs proliferation, migration, and invasion. Besides, Sar lowered the elevated STIM1 and Orai expression in ox-LDL-treated VSMCs. Further, STIM1 elevation partially abrogated the impacts of Sar on the proliferation, migration, and invasion of VSMCs challenged with ox-LDL. Conclusions In conclusion, Sar might reduce STIM1 expression to impede the aggressive phenotypes of ox-LDL-treated VSMCs.

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Cardiovascular risk profile of young adults: Changes over time

Cited by 4 publications

References 23 publications

Overweight and associated factors in young adult student girls

Overweight and associated factors in young adult student girls

Body Fat Accumulation is Associated with Early Arterial Changes in HIVInfected Children

Sarsasapogenin blocks ox-LDL-stimulated vascular smooth muscle cell proliferation, migration, and invasion through suppressing STIM1 expression

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