Cardiovascular Syphilis: A CLINICAL STUDY OF 578 CASES

Syphilitic Arthritis: Diagnostic Problems with Special Reference to Congenital Syphilis

“…The occurrence, at the age of 9 years, of both painful and painless joint swellings preceding the development of interstitial keratitis and choroiditis is of significance, and the response to anti-syphilitic treatment was excellent. Cases of combined syphilitic and rheumatic valvular disease have been reported by Plice and Edinburg (1942), and by Lisa, Solomon, andEckstein (1942), andO'Brien, Smith, andFisher Keller (1955) described 578 cases of cardiovascular syphilis. In our case, 6 years after the demonstration of a mitral and aortic murmur, the cardiac condition has deteriorated without any subjective symptoms; there is now evidence of marked pulsation and prominence of the ascending aorta and early aneurysmal dilatation, but still no evidence of left atrial enlargement.…”

Cardiovocal syndrome due to cardiovascular syphilis

“…Aneurysmal compression on adjacent structures can be the cause of primary clinical presentations. Involvement of the recurrent laryngeal nerve may give rise to hoarseness, aphonia, or a typical brassy cough 3 . Cardiovascular syphilis is suggested by symptoms and signs of aneurysmal compression of adjacent structures, particularly stridor or hoarseness 4 .…”

Review of hospitalized cases of general paralysis of the insane.

“…The apparent increase in signs of tabes and cardiovascular involvement (Barnett, 1955) O'Brien, Smith, and Fisherkeller (1955) and Raaschou-Nielsen and Kopp (1957) have emphasized the well-recognized association of cardiovascular syphilis and late neurosyphilis. The finding of 56 per cent.…”