Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention

Marciniak, Aleksandra; Nawrocka-Rutkowska, Jolanta; Brodowska, Agnieszka; Wiśniewska, Barbara; Starczewski, Andrzej

doi:10.5604/12321966.1226842

Cited by 44 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hyperandrogenemia is capable of activating mononuclear cells and induce inflammation, which can conversely increase androgen production from ovaries in PCOS [25]. IL-6 is associated with insulin resistance and hyperandrogenism, and it is regarded as an early low-grade chronic inflammatory marker in PCOS patients [26, 27]. Higher TNF-α has a positive correlation with serum androgen level in overweight and obese adolescents PCOS [28], it can cause proliferation of theca-interstitial cells in ovaries and consequently hyperandrogenemia [29].…”

Section: Discussionmentioning

confidence: 99%

Abnormal expression of HSP70 may contribute to PCOS pathology

Ding

et al. 2019

J Ovarian Res

View full text Add to dashboard Cite

Background The mechanism of the pathological change of polycystic ovary syndrome (PCOS) is still unclear. Previous studies have shown that PCOS is a chronic nonspecific low-grade inflammatory condition, and that heat shock protein (HSP)70 has a potent anti-inflammatory property. So the aim of this study is to investigate the correlation between HSP70 and the hormones and inflammatory factors and to find out the role of HSP70 in the pathogenesis of PCOS. Methods Twenty female Sprague–Dawley (SD) rats (aged 23 days and weighted 80-90 g) were randomly divided into two groups ( n = 10 per group), PCOS group and control group. PCOS group were subcutaneously injected with 6 mg/100 g dehydro-epiandrosterone (DHEA) for 20 consecutive days, the control group were subcutaneously injected with a solvent of equivalent amount. All the samples were collected in the morning fasting state, 12 h after the last administration. Histological examinations of ovarian tissues were analyzed. Hormone levels and inflammatory factors levels were measured by enzyme-linked immunosorbent assay (ELISA) kits. Results Serum concentrations of testosterone (T) and luteinizing hormone (LH) were significantly higher in the PCOS group than the control group ( P < 0.001), but the concentrations of estradiol (E 2 ), follicle stimulating hormone (FSH) and insulin didn’t show significant difference between these two groups. All the concentrations of inflammatory factors including C-reactive protein (CRP), interleukin (IL)-6, IL-18, and tumor necrosis factor (TNF)-α. were significantly higher in PCOS group than the control group ( P < 0.001). The expressions of HSP70 were significantly lower in serum but higher in ovarian tissues in the PCOS group than the control group. Spearman rank correlation analysis showed strong negative correlation of serum HSP70 levels with T, LH and all the detected inflammatory factors. Conclusion The abnormal expression of HSP70 correlated with testosterone and inflammatory factors, which indicates that HSP70 may play an important role in PCOS pathology.

show abstract

Section: Discussionmentioning

confidence: 99%

Abnormal expression of HSP70 may contribute to PCOS pathology

Ding

et al. 2019

J Ovarian Res

View full text Add to dashboard Cite

show abstract

“…IL-18 plays an important role in follicular growth and oocyte maturation [10]. IL-6 is associated with hyperandrogenism and insulin resistance in PCOS patients [11]; local inflammation in PCOS ovaries could impair follicular growth and maturation [11]. Inflammation has now been considered as a potential contributor to the pathogenesis of PCOS.…”

Section: Introductionmentioning

confidence: 99%

Shaoyao-Gancao Decoction alleviated hyperandrogenism in a letrozole-induced rat model of polycystic ovary syndrome by inhibition of NF-κB activation

et al. 2019

View full text Add to dashboard Cite

Shaoyao-Gancao Decoction (SGD) has been widely used for the treatment of gynopathy. The present study aimed to evaluate the therapeutic effect and potential mechanism of SGD on hyperandrogenism in polycystic ovary syndrome (PCOS) rats. In the present work, SGD was orally administrated to the PCOS rats at the dose of 12.5, 25, and 50 g/kg/d for 14 consecutive days. UPLC–MS/MS was performed to identify the main chemical components of SGD. Body weight, ovarian weight, cystic dilating follicles, and serum levels of steroid hormones were tested to evaluate the therapeutic effect of SGD. In order to further clarify the underlying mechanism, we also measured mRNA and the protein levels of NF-κB, NF-κB p65, P-NF-κB p65, and IκB by RT-qPCR and Western blotting techniques. Our results showed that SGD treatment significantly alleviated hyperandrogenism in PCOS rats as evidenced by reduced serum levels of T and increased E2 and FSH levels. In addition, SGD effectively reduced the phosphorylation of NF-κB p65 and increased the expression of IκB. Results of the present study demonstrated that SGD could ameliorate hyperandrogenism in PCOS rats, and the potential mechanism may relate to the NF-κB pathway.

show abstract

“…Elevated serum CRP levels are linked to several health risk factors experienced by women with PCOS, particularly IR and heightened risk of type 2 diabetes. 7 15 16 Chronic inflammation also contributes to endothelial dysfunction, exacerbating the development of atherosclerotic plaques, triggering the onset of CVD. 17 As such inflammation has been associated with both CVD and coronary artery disease in women with PCOS.…”

Section: Introductionmentioning

confidence: 99%

Assessing C reactive protein/albumin ratio as a new biomarker for polycystic ovary syndrome: a case–control study of women from Bahraini medical clinics

et al. 2018

View full text Add to dashboard Cite

ObjectivePolycystic ovary syndrome (PCOS) is an endocrine disorder affecting approximately one in seven women who experience androgen excess, menstrual cycle irregularities, frequent anovulation and a tendency for central obesity and insulin resistance. Chronic subclinical inflammation is now recognised as being common in the context of PCOS, which led to the postulation that PCOS may fundamentally be an inflammatory process. This study aimed to: (1) evaluate serum C reactive protein (CRP)/albumin ratio as a potential predictive biomarker for PCOS; (2) compare the relationship between CRP/albumin and PCOS to variables classically associated with the syndrome.DesignCase–control study.SettingAdult obstetrics/gynaecology, endocrinology and outpatient clinics; university hospital in Bahrain.Participants200 premenopausal women with a diagnosis of PCOS, and 119 ethnically matched eumenorrheic premenopausal women.Main outcome measuresCRP/albumin ratio, anthropometric measures, insulin resistance, androgen excess.ResultsIndependent of body mass index (BMI), receiver operating characteristic curve for CRP/albumin ratio as a selective biomarker for PCOS was 0.865 (95% CI 0.824 to 0.905), which was more sensitive than CRP alone. Binary regression analysis showed that CRP/albumin ratio outperformed classical correlates, Free Androgen Index and insulin resistance, in predicting PCOS for every BMI category.ConclusionCRP/albumin ratio, a marker for inflammation related to metabolic dysfunction, was found to have a stronger association with PCOS than either androgen excess or insulin resistance. Inflammation is known to be influenced by adiposity, but relative to controls, women with PCOS have higher levels of CRP/albumin irrespective of BMI. These findings support the view that inflammation plays a central role in the pathophysiology of PCOS.

show abstract

Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention

Cited by 44 publications

References 0 publications

Abnormal expression of HSP70 may contribute to PCOS pathology

Abnormal expression of HSP70 may contribute to PCOS pathology

Shaoyao-Gancao Decoction alleviated hyperandrogenism in a letrozole-induced rat model of polycystic ovary syndrome by inhibition of NF-κB activation

Assessing C reactive protein/albumin ratio as a new biomarker for polycystic ovary syndrome: a case–control study of women from Bahraini medical clinics

Contact Info

Product

Resources

About