Care Regimen and Lens Material Influence on Silicone Hydrogel Contact Lens Deposition

Zhao, Zhenjun; Carnt, Nicole; Aliwarga, Yulina; Wei, Xiaojia; Naduvilath, Thomas; Garrett, Qian; Korth, Jurgen; Willcox, Mark

doi:10.1097/opx.0b013e318196a74b

Cited by 83 publications

(64 citation statements)

References 35 publications

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“…This also confirms prior studies that reported that lotrafilcon B materials sorbed less lipid than balafilcon A materials in worn lenses 5,8 and also in lenses incubated in vitro. 12 Lorentz et al 9 performed a similar study with lenses incubated in ATF; they found approximately 1/6 to 1/10 the sorption on balafilcon A than we report herein.…”

Section: Sorption On Four Commercial Lensessupporting

confidence: 93%

Quantitation of cholesterol and phospholipid sorption on silicone hydrogel contact lenses

et al. 2013

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The introduction of silicone hydrogel (SiHy) contact lenses to the consumer marketplace necessitates study of the susceptibility of these lenses to spontaneous deposition by hydrophobic lipid components of ocular tears. The use of radioisotopes to measure lipid sorption on SiHy contact lenses gives precise and accurate results but requires institutional infrastructure and compels efficient lipid removal from the lens. This study compares three methods of quantitating phospholipid and cholesterol sorption on SiHy lenses using radiolabeled cholesterol and phosphatidylcholine that were sorbed on lenses from an artificial tear fluid. A triple extraction technique using n-propanol gives the most reliable results. Comparison of sorption on SiHy lenses shows that balafilcon A and senofilcon A lenses sorb similar amounts, while lotrafilcon B lenses sorb comparatively less.

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Section: Sorption On Four Commercial Lensessupporting

confidence: 93%

Quantitation of cholesterol and phospholipid sorption on silicone hydrogel contact lenses

et al. 2013

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“…MPSs can vary in their efficiency with differences in their composition, manufacturer, and cleaning and storage times. 22,30 While the staining results for the MPS control lenses were similar to those found after exposure to ATF, the rationale for the results is very different. In this instance, MPS components associate with the lens HDs in an attempt to block biofouling, thus also decreasing the binding sites for staining.…”

Section: Discussionmentioning

confidence: 71%

“…1 Lotrafilcon A, on the other hand, uses a plasma coating treatment that coats the lens surface with a 25-nm thick hydrophilic polymer. 21,22 Galyfilcon A (Acuvue Advance; Johnson & Johnson Vision Care, Jacksonville, FL) and senofilcon A (Acuvue Oasys; Johnson & Johnson Vision Care) do not utilize such techniques, but rather use internal wetting agents to increase hydrophilicity. 21 Current methodologies to determine the hydrophobicity of contact lens surfaces are limited to surface energy measurements such as captive bubble, sessile drop, and Wilhelmy plate contact angles.…”

Section: Purposementioning

confidence: 99%

Visualizing Hydrophobic Domains in Silicone Hydrogel Lenses with Sudan IV

Jacob

Levet

Edwards

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.A lipophilic dye is used to investigate the degree to which the surface and bulk hydrophobic domains of the lenses can be imaged and to identify specific changes in the availability of those domains after in vitro wear and cleaning conditions. The effect of a multipurpose solution (MPS), OPTI-FREE RepleniSH, on lens hydrophobic domains was also investigated.METHODS. Hydrophobic domains were determined using a saturated solution of Sudan IV. Staining periods of 30 minutes and 16 hours were used to determine surface versus bulk hydrophobic domains. Four types of silicone hydrogel lens materials were tested. The degree of staining was visually documented by photography and quantitatively determined by extraction and analysis of the total amount of dye adsorbed.RESULTS. Specific differences in staining were found for all control lenses. Exposure to in vitro wear conditions significantly decreased the staining response for all lens types as compared with unworn lenses (P ¼ 0.001). However, the trend of staining remained the same: balafilcon A > galyfilcon A > senofilcon A > lotrafilcon B. MPS decreased the extent of staining; the degree of its effect varied with lens type.CONCLUSIONS. Hydrophobic staining with Sudan IV visualized domains on and within silicone hydrogel lenses. Differences in staining response after exposure to wear and cleaning conditions indicate the potential for protein and lipid deposition on the different lens types and the ability of MPS to affect that deposition. Hydrophobic staining may be useful for determining differences in surface modification and lipophilicity of silicone hydrogel lenses. (Invest Ophthalmol Vis Sci. 2012;53:3473-3480)

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“…6,7 Ex vivo, free cholesterol and phospholipids have been identied and quantied on a range on silicone hydrogel lens formulations. 3,8 Importantly however, recent characterization of the tear lipidome suggests that free cholesterol and phospholipids are only minor components of the endogenous tear lm.…”

Section: Introductionmentioning

confidence: 99%

“…These deposits are primarily composed of lipids and protein adsorbed from the tear lm and corneal surface. 3,4 Extensive studies have identied and quantied the protein components of these deposits, and recent reports demonstrated that the proles of protein deposition are dependent on contact lens formulation. 3,5 In contrast, limited information is available regarding the lipid composition of deposits on silicone hydrogel contact lenses.…”

Section: Introductionmentioning

confidence: 99%

Automated surface sampling of lipids from worn contact lenses coupled with tandem mass spectrometry

Brown

Huxtable

Willcox

et al. 2013

Analyst

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The deposition of biological material (biofouling) onto polymeric contact lenses is thought to be a major contributor to lens discomfort and hence discontinuation of wear. We describe a method to characterize lipid deposits directly from worn contact lenses utilizing liquid extraction surface analysis coupled to tandem mass spectrometry (LESA-MS/MS). This technique effected facile and reproducible extraction of lipids from the contact lens surfaces and identified lipid molecular species representing all major classes present in human tear film. Our data show that LESA-MS/MS is a rapid and comprehensive technique for the characterization of lipidrelated biofouling on polymer surfaces.

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Care Regimen and Lens Material Influence on Silicone Hydrogel Contact Lens Deposition

Abstract: Lens polymer (possibly associated with surface characteristics) is a prominent factor affecting lipid and protein accumulation. Within a lens polymer type, lens care solutions exhibit varying effectiveness in reducing protein and lipid accumulation.

Cited by 83 publications

References 35 publications

Quantitation of cholesterol and phospholipid sorption on silicone hydrogel contact lenses

Quantitation of cholesterol and phospholipid sorption on silicone hydrogel contact lenses

Visualizing Hydrophobic Domains in Silicone Hydrogel Lenses with Sudan IV

Automated surface sampling of lipids from worn contact lenses coupled with tandem mass spectrometry

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