We investigated the relationships between decision‐making styles, career decision self‐efficacy, and career adaptability among high school students. We also sought to determine whether gender moderates the relationships among these three constructs. A total of 216 Serbian final‐year high school students responded to career adaptability and decision‐making measures. Results of structural equation modeling showed that career decision self‐efficacy mediates a positive relationship between the rational and intuitive styles and a negative relationship between the dependent style and career adaptability. The rational style only had a direct effect on career adaptability. Gender moderated one path—a regression weight of self‐efficacy on career adaptability. For male students, self‐efficacy was not a significant predictor of career adaptability. The results suggest that career counselors might approach students differently depending on students' gender and that the role of gender in career decision‐making and adaptability processes should be investigated further.