The employment conditions of persons with disabilities are influenced by modern trends in the transformation of social and labor relations associated with the new industrialization and digitalization, social policy aimed at improving the quality of life of this category of persons and legislative changes. So, in the Omsk region it is planned to change the quota of jobs for people with disabilities. The purpose of the study, thus, was to study the process of employment of persons with disabilities in terms of industrialization, to identify the motives of employers involved in the implementation of the state policy to promote employment of disabled people in working age in the Omsk region. This study analyzes statistical information on trends in employment of persons with disabilities. Based on the survey of employers there was revealed their attitude to increasing the quota for employment of persons with disabilities, were studied the problems faced by employers and were identified support measures in this area, relevant to organizations. As a result of research of problems in the field of employment of disabled people, there were given recommendations on change of conditions of quotas and improvement of the mechanism of assistance of employment of disabled people in the Omsk region with activation of activity of such subjects as employers, public organizations, and educational institutions.