Caregiver Burden in Primary Congenital Glaucoma

Kantipuly, Aditi; Pillai, Manju; Shroff, Sujani; Khatiwala, Rakhee; Raman, Ganesh V; Krishnadas, Subbaiah Ramasamy; Robin, Alan L.; Ehrlich, Joshua R.

doi:10.1016/j.ajo.2019.05.003

Cited by 22 publications

(26 citation statements)

References 24 publications

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“… 9 10 As the disease and its management essentially requires lifelong monitoring, there is also a significant impact on the caregiver quality of life, indicating that evidence-based interventions are required at a multitude of levels to optimise patient outcomes. 11 …”

Section: Introductionmentioning

confidence: 99%

“…People with childhood glaucoma have a reduced quality of life8 and visual acuity is often poor with approximately 25% of children with PCG meeting the WHO’s definition of blindness in one Indian cohort 9 10. As the disease and its management essentially requires lifelong monitoring, there is also a significant impact on the caregiver quality of life, indicating that evidence-based interventions are required at a multitude of levels to optimise patient outcomes 11…”

Section: Introductionmentioning

confidence: 99%

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A systematic review of clinical practice guidelines for childhood glaucoma

et al. 2022

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ObjectiveTo conduct a systematic review to identify and critically appraise clinical practice guidelines on the assessment, diagnosis and management of childhood glaucoma.Methods and analysisA systematic literature search of databases and professional websites for clinical practice guidelines published on eye conditions between 2010 and April 2020 in English was conducted. Identified guidelines were screened for relevance to childhood glaucoma and exclusion criteria applied. Guidelines that passed the screening and quality appraisal with the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and, if they achieved a mean score of ≥45 and ≥3 on subsets of 9 and 5 AGREE II items, respectively, were selected for inclusion and data extracted using a standardised form.ResultsFollowing screening and critical appraisal, three guidelines were included for data extraction. None of the three guidelines was specifically developed for childhood glaucoma. A consistent recommendation was that children should undergo some form of eye screening examination or a comprehensive eye assessment to detect paediatric eye disease. Children at high risk of childhood glaucoma should undergo additional screening. One clinical practice guideline recommended interventions for childhood glaucoma consisting of tube surgery and topical beta-blockers or carbonic anhydrase inhibitors. Recommended interventions for childhood glaucoma were based on low-quality to moderate-quality evidence or expert opinion.ConclusionBased on our selection criteria, we did not identify any high-quality clinical practice guidelines specifically targeted at childhood glaucoma. This is compounded by the lack of high-quality evidence on childhood glaucoma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A systematic review of clinical practice guidelines for childhood glaucoma

et al. 2022

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“…1,2 Its main pathology lies in the trabecular meshwork maldevelopment (isolated trabeculodysgenesis) that leads to increase outflow resistance to the aqueous drainage. [3][4][5][6] The treatment of primary congenital glaucoma is essentially a surgical procedure. The role of topical antiglaucoma medications is only temporary before the preparation for the surgical procedure.…”

Section: Introductionmentioning

confidence: 99%

<p>Non-Penetrating Deep Sclerectomy versus Trabeculectomy in Primary Congenital Glaucoma</p>

Elhofi¹,

Helaly²

2020

OPTH

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Purpose: To evaluate the safety and efficacy of non-penetrating deep sclerectomy with a collagen implant versus trabeculectomy in primary congenital glaucoma. Subjects and Methods: This was a retrospective interventional comparative nonrandomized clinical study that included 80 eyes of 80 children presenting with primary congenital glaucoma under the age of 3 years. Forty eyes have undergone non-penetrating deep sclerectomy (NPDS) and the other 40 eyes have undergone penetrating trabeculectomy. The main outcome measure was the reduction in intraocular pressure (IOP). Secondary outcomes included percentage of patients with complete and qualified success, need for topical antiglaucoma medications, rate of complications, and need for further interventions. Complete success of the surgical outcome was considered an IOP ≤16 mmHg with no antiglaucoma medications. Qualified success was considered an IOP ≤16 mmHg using antiglaucoma medications. Results: The mean preoperative IOP was 27.4 ± 6.9 and 28.5 ± 6.6 mmHg in NPDS and trabeculectomy groups, respectively (p = 0.175). At the end of the follow-up period, the mean IOP was 11.2 ± 4.5 and 11.1 ± 3.4 mmHg with a mean reduction of 16.2 and 17.4 mmHg in NPDS and trabeculectomy groups, respectively. At the end of the follow-up period, ie at 36 months postoperative, the complete success rate was 60% (24 eyes) versus 57.5% (23 eyes), the qualified success rate was 25% (10 eyes) versus 25% (10 eyes), the overall success rate was 85% (34 eyes) versus 82.5% (33 eyes), and the rate of failure was 15% (6 eyes) versus 17.5% (7 eyes) in NPDS and trabeculectomy groups, respectively (p = 0.952). Eight cases (20%) of the trabeculectomy group had shallow anterior chamber. None of the NPDS group cases suffered from shallow anterior chamber. Conclusion: Non-penetrating deep sclerectomy appears to be an efficient and safe surgical alternative to penetrating trabeculectomy in treatment of primary congenital glaucoma. Nonpenetrating deep sclerectomy has fewer postoperative complications in comparison to penetrating trabeculectomy with a comparative postoperative reduction in the intraocular pressure and overall success rates. Trial Registration: The trial was registered on 11/01/2020 with number PACTR202002874953456 (https://pactr.samrc.ac.za).

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“…Moreover, specific aspects of ICG strain for AMD like that associated with frequent treatment visits to clinic have been flagged [14,16]. There has also been an effort to assess ICG strain in paediatric glaucoma Caregiver Strain in Glaucoma 5 patients [18,19]. However, there has been no attempt to quantify ICG strain in adult COAG and this is the main idea presented in this paper.…”

Section: Introductionmentioning

confidence: 99%

Taking the strain? Impact of glaucoma on patients' informal caregivers

McDonald

Turnbull

Chang

et al. 2019

Eye

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What was known before  Chronic open angle glaucoma (COAG) can cause difficulties with activities of daily living such as driving and mobility.  Other chronic eye diseases, for example, age related macular degeneration lead to an increase in reliance on family support networks; this is termed informal caregiving. What this study adds  The first to estimate caregiver strain in a sample of COAG caregivers using a validated instrument.  Informal caregiver strain is negligible in most patients consecutively sampled from a glaucoma clinic in England.  ICG strain becomes inflated in patients with advanced visual field (VF) loss in COAG.  ICG strain increases moderately with worsening VF's but in our sample some of this could be explained by worse general health.

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Caregiver Burden in Primary Congenital Glaucoma

Cited by 22 publications

References 24 publications

A systematic review of clinical practice guidelines for childhood glaucoma

A systematic review of clinical practice guidelines for childhood glaucoma

<p>Non-Penetrating Deep Sclerectomy versus Trabeculectomy in Primary Congenital Glaucoma</p>

Taking the strain? Impact of glaucoma on patients' informal caregivers

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