Carence martiale fonctionnelle, inflammation et fatigue après radiothérapie

Grellier, N.; Deray, Gilbert; Yousfi, Amani; Khodari, W.; Bouaita, Ryan; Belkacémi, Yazid

doi:10.1016/j.bulcan.2015.06.001

Cited by 11 publications

(2 citation statements)

References 44 publications

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“…Fatigue induced by RT may be the body’s response to a toxic insult [38]. Several studies have indicated that RIF is associated with anemia and functional iron deficiency [39–44]. Heme levels (red blood cells, hemoglobin, hematocrit) are found to be correlated with fatigue severity at completion of external beam radiation therapy (EBRT) suggesting that stabilizing heme levels may prevent worsening of fatigue symptoms during EBRT [41].…”

Section: Proposed Mechanisms Of Rifmentioning

confidence: 99%

The Etiology and management of radiotherapy-induced fatigue

Hsiao

Daly

Saligan

2016

Expert Review of Quality of Life in Cancer Care

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Fatigue is one of the most common side-effects accompanying radiotherapy, but arguably the least understood. Radiotherapy-induced fatigue (RIF) is a clinical subtype of cancer treatment-related fatigue. It is described as a pervasive, subjective sense of tiredness persisting over time, interferes with activities of daily living, and is not relieved by adequate rest or sleep. RIF is one of the early side-effects and long-lasting for cancer patients treated with localized radiation. Although the underlying mechanisms of fatigue have been studied in several disease conditions, the etiology, mechanisms, and risk factors of RIF remain elusive, and this symptom remains poorly managed. The purpose of this paper is to review and discuss recent articles that defined, proposed biologic underpinnings and mechanisms to explain the pathobiology of RIF, as well as articles that proposed interventions to manage RIF. Understanding the mechanisms of RIF can describe promising pathways to identify at-risk individuals and identify potential therapeutic targets to alleviate and prevent RIF using a multimodal, multidisciplinary approach.

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Section: Proposed Mechanisms Of Rifmentioning

confidence: 99%

The Etiology and management of radiotherapy-induced fatigue

Hsiao

Daly

Saligan

2016

Expert Review of Quality of Life in Cancer Care

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“…The passage of iron through the macrophage membrane is rather complicated and under control of a few components, mainly the peptides ferroportin and hepcidin. While ferroportin exports iron from the macrophages, hepcidin, which is synthesized in the liver, blocks iron release from the cells and prevents its absorption from duodenal enterocytes with a subsequent development of iron deficiency and anemia (Michels et al, 2015;Ganz and Nemeth, 2015;Grellier et al, 2015;Smith et al, 2013). Likewise, hepcidin and ferroportin mediate the iron flux into bacteria resulting in disturbances in bacterial growth (Ward et al, 2011), whereas iron accumulation in the macrophages is the base of their bacteriostatic capacity (Recalcati et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Does Iron Modulate Cytokine Production by Desferrioxamine Treated Mononuclear Cells?

Bessler

Djaldetti

2018

OnLine Journal of Biological Sciences

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Iron is an essential element for maintaining the normal function of cellular and multicellular organisms and it is closely associated with inflammation and immunity. Macrophages and lymphocytes play an important role in its homeostasis. Hereby we have evaluated cytokine production by iron depleted and iron supplemented human peripheral blood mononuclear cells (PBMC) from healthy adult donors. Non-stimulated or stimulated PBMC (lipopolysaccharide-LPS or phorbol-myristate acetate-PMA and ionomycin) were incubated for 24 h without or with desferrioxamine (DFO) and the quantity of TNFα, IL-1β, IL-6, IFNγ, IL-2, IL-10 and IL-1ra in the supernatants was evaluated using ELISA kits. In addition, cytokine levels were determined in supernatants of cultures to which DFO was added for 2 h followed by 24 h of incubation with iron. The secretion of IL-1β, IL-6 and IL-1ra by non-stimulated PBMC and that of IL-1β by LPS-stimulated cells was dose-dependently enhanced following incubation with increasing concentrations of DFO between 25 and 100 µM. On the other hand LPS-induced production of IL-10 and PMA/ionomycin stimulated IL-2 and IFNγ secretion was dose dependently reduced. The inhibited IFNγ, IL-2 and IL-10 secretion by stimulated PBMC caused by DFO was reversed after incubation with iron at concentrations similar to those in human serum. However, the inhibition of LPS-induced IL-1ra or IL-1β production induced by DFO was not affected by iron supplementation. The results of the study underline the importance of intra and/or extracellular iron concentration and DFO for the release of inflammatory cytokines by human peripheral blood mononuclear cells.

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Anti‐anemic potential of Eruca sativa L. in iron‐deficient rat model; network pharmacology profiling

Javed,

Shahzadi,

Yousaf

et al. 2024

Food Science & Nutrition

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Iron deficiency anemia is a global health concern, affecting around 2 billion people. Oral iron therapy often causes severe gastro‐intestinal issues. Eruca sativa, member of the Brassicaceae family, is valued in traditional medicine and renowned for its rich iron and vitamin C content. This study aims to evaluate the anti‐anemic properties of E. sativa extract in vivo and identify its compounds targeting anemia mechanisms using network pharmacology. Thirty‐two Sprague–Dawley rats (200 ± 250 g) were split into two distinct groups, iron‐deficient and iron‐sufficient. Three different doses (200, 400, and 800 mg/kg) of aqueous extract of E. sativa were checked against anemia by studying hematological, oxidative stress, and histopathological parameters. GC–MS analysis of E. sativa revealed its phytochemical profile, followed by ADME screening. Network pharmacology explored targets related to iron deficiency anemia, with oral bioavailability and drug likeness assessment for compounds. The administration of extracts significantly improved various blood parameters, including osmotic fragility, Hb, RBCs, MCV, PCV, and alkaline phosphatase; catalase activity; and histopathological parameters such as liver in both iron‐deficient and iron‐sufficient rats (p < .001). Seventy‐nine compounds were identified in E. sativa aqueous extract, with only six of them found to be bioavailable and drug‐like against multiple targets. Gene ontology and pathway analysis revealed their diverse molecular, biological, and cellular functions. One gene EGFR was found to have functional association with ID anemia, suggesting potential for using E. sativa extracts. The study concludes that E. sativa extract has potential for iron deficiency anemia treatment, offering hope for future pharmaceutical interventions.

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Carence martiale fonctionnelle, inflammation et fatigue après radiothérapie

Cited by 11 publications

References 44 publications

The Etiology and management of radiotherapy-induced fatigue

The Etiology and management of radiotherapy-induced fatigue

Does Iron Modulate Cytokine Production by Desferrioxamine Treated Mononuclear Cells?

Anti‐anemic potential of Eruca sativa L. in iron‐deficient rat model; network pharmacology profiling

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