Caries-inhibitory effect of titanium tetrafluoride in rats

Skartveit, Liv; Ab, Tveit; Ka, Selvig

doi:10.3109/00016359109005891

Cited by 16 publications

(13 citation statements)

References 18 publications

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“…They found that TiF4 with a concentration of one percent was more effective in caries prevention, when compared to the equivalent solution (in wise of concentration) of SnF2, NaF and aluminum phosphate fluoride. This finding was also supported by much earlier studies (23, 24). Although the xylitol solution did not display any antimicrobial effects in our study, some previous studies have documented it to have inhibiting effects on bacterial growth.…”

Section: Discussionsupporting

confidence: 90%

Comparison of antimicrobial effects of titanium tetrafluoride, chlorhexidine, xylitol and sodium fluoride on streptococcus mutans: An in-vitro study

et al. 2017

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IntroductionNo studies have yet documented the bactericidal effects of TiF4, and its role in the treatment of dental caries, and no definite protocol has been introduced to regulate its use. The aim of this study was to determine the antimicrobial/bactericidal effects of TiF4 on Streptococcus Mutans (S. Mutans) and to compare it with chlorhexidine (Chx), sodium fluoride (NaF) and xylitol.MethodsThis study was conducted at the Shiraz University of Medical Sciences microbiology laboratory during March 2015 to September 2015. In this in-vitro study, first a bacterial suspension was prepared and adjusted to a 0.5 McFarland standard (equivalent to 1×108 CFU/ml). The minimal inhibitory concentration (MIC) and minimal bactericidal concentrations (MBC) of TiF4, Chx, NaF and xylitol were assessed using broth microdilution assay and disk diffusion methods. In order to neutralize the acidic nature of TiF4, we used a sodium hydroxide preparation to obtain a pH of 7.2 and repeated all of the previous tests with the neutralized TiF4 solution. We reported the final results as percentages where appropriate.ResultsThe MIC of TiF4, NaF and Chx for S. Mutans were 12.5%, 12.5% and 6.25%, respectively. At a concentration of 12.5% the inhibition zone diameters were 9 mm, 15mm and 14mm for TiF4, NaF and Chx, respectively. The MBC was 25%, 12.5% and 12.5% for TiF4, NaF and Chx, respectively. Xylitol failed to show any bactericidal or growth inhibitory effect in all of its concentrations. When we repeated the tests with an adjusted pH, identical results were obtained.ConclusionTiF4 solutions have anti-growth and bactericidal effects on S. Mutans at a concentration of 12.5% which is comparable with chlorhexidine and NaF, indicating the possible use of this solution in dental practice as an anti-cariogenic agent, furthermore the antimicrobial activity is unaffected by pH of the environment.

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Section: Discussionsupporting

confidence: 90%

Comparison of antimicrobial effects of titanium tetrafluoride, chlorhexidine, xylitol and sodium fluoride on streptococcus mutans: An in-vitro study

et al. 2017

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“…[511] An approximately 0.1 micro-mm thick, electron-dense coating along the surface of the demineralized layer is a constant finding in the Titanium Tetafluoride-treated surfaces. [8] Among the fluoride preparation, 2% Sodium fluoride was commonly used for topical application as it was found that it had a caries preventive effect. Various percentages of titanium tetrafluoride were tried, such as, 1%, 3.4%, and 4%.…”

Section: Discussionmentioning

confidence: 99%

Effect of 4% titanium tetrafluoride application on shear bond strength of composite resin: An in vitro study

Saraswathi

Manjunath

2011

J Conserv Dent

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Aims:The objective of thisstudy is to evaluate and compare 4% titanium tetrafluoride with 2% Sodium fluoride, and the bond strength of composite resin with dentin and their effects on the smear layer.Materials and Methods:Fifty freshly extracted non-carious molar and premolar teeth were selected. The occlusal surfaces of the teeth were ground, to prepare flat dentin surfaces at a depth of 2 mm and were randomly grouped with 10 specimens in each. Group I (Etching + Adhesive + Composite resin) was taken as a control group. In Group II, 4% titanium tetrafluoride was applied before etching and in Group III, 4% titanium tetrafluoride was applied after etching. In Group IV, 2% Sodium fluoride was applied before etching and in Group V, 2% Sodium fluoride was applied after etching. Shear bond strength was tested using the Lloyds Universal testing machine and was recorded in MPa.Results:The results were statistically analyzed using the one-way Anova test. Group III showed the highest bond strength among the experimental groups, but less than the control group.Conclusions:Under the conditions of this in vitro study, titanium tetrafluoride did not significantly affect the bond strength of the composite. Sodium fluoride was found to deleteriously affect the bond strength of the composite.

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“…Much effort has been and is currently made to find out whether novel formulations could make it possible to increase the effect of fluoride in caries prevention. Titanium tetrafluoride makes an example of a formulation regarding which the results of several studies look promising [Reed and Bibby, 1976;Derand et al, 1989;Skartveit et al, 1991;de Oliveira and Cordeiro, 1995;Buyukyilmaz et al, 1997;Tezel et al, 2002]. Until now, however, there is no evidence stemming from large-scale randomized clinical trials on its applicability and superiority in everyday life.…”

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How to Improve the Effectiveness of Caries-Preventive Programs Based on Fluoride

Hausen¹

2004

Caries Res

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During recent years, an increasing number of reports have been published in which the observed caries-preventive effect of fluoride has been lower than could have been expected on the basis of the earlier literature. The current low levels of caries occurrence and the widespread use of fluoridated toothpastes as well as other fluoride products and methods have been suggested as reasons for the reduced relative effect of fluoride from any single source. Theoretically, one can improve the effectiveness of fluoride in caries-preventive programs by using measures that are more effective than the previous ones and still safe and feasible in everyday conditions. Another possibility is to direct fluoride-based prevention to high caries risk susceptible individuals who are most likely to benefit from it. Thirdly, one can enhance the intensity of existing fluoride prevention by increasing the frequency of applications, but this is of course worthwhile only if the recipients are lacking sufficient exposure to fluoride. In theory, people themselves could easily take care of their adequate fluoride supply by using fluoride toothpastes and/or other home use products frequently enough to maintain a sufficient salivary fluoride concentration at all times. Many people are unwilling to adopt healthy lifestyles, however, and therefore caries-preventive programs will remain necessary for the foreseeable future. Fluoride is the backbone of all such programs. Since conditions strongly determine the usefulness of caries prevention including different fluoride regimes, more research is still needed to monitor the effectiveness of caries-preventive programs and their components in variable conditions of today and tomorrow.

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Caries-inhibitory effect of titanium tetrafluoride in rats

Cited by 16 publications

References 18 publications

Comparison of antimicrobial effects of titanium tetrafluoride, chlorhexidine, xylitol and sodium fluoride on streptococcus mutans: An in-vitro study

Comparison of antimicrobial effects of titanium tetrafluoride, chlorhexidine, xylitol and sodium fluoride on streptococcus mutans: An in-vitro study

Effect of 4% titanium tetrafluoride application on shear bond strength of composite resin: An in vitro study

How to Improve the Effectiveness of Caries-Preventive Programs Based on Fluoride

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