Caries preventive effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a meta-analysis

Yengopal, Veerasamy; Mickenautsch, Steffen

doi:10.1080/00016350903160563

Cited by 123 publications

(96 citation statements)

References 37 publications

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“…The review of Azarpazhooh et al 7 concluded that the quality and quantity of articles reviewed were insufficient to generate conclusive evidence of the long term effectiveness of casein derivative compounds, especially CPP-ACP.…”

Section: Systematic Reviewsmentioning

confidence: 99%

“…The first of these, conducted by Azarpazhooh et al 7 , reunited randomized and quasi randomized clinical studies, published up to October 2007, which tested the efficacy of casein derivatives (among them CPP-ACP) in the diverse forms of dental application.…”

Section: Systematic Reviewsmentioning

confidence: 99%

“…One of them was the study that was included in the systematic review of Azarpazhooh et al 7 , which was that of Anderson et al, 9 . The other study refers to that of Morgan et al 19 , in which 2,720 children used chewing gum with or without the addition of CPP-ACP.…”

Section: Systematic Reviewsmentioning

confidence: 99%

“…This complex acts as a reservoir of Ca and P that bonds to the plaque and tooth surface. In the face of an acid medium CPP-ACP releases Ca and P ions, so that mineral supersaturation is maintained in the environment outside of the tooth, and consequently, reduction in the demineralization process and stimulation of remineralization is achieved [7][8] . Furthermore, the nanocomplex of CPP-ACP has been shown to have a synergic effect on fluoridated compounds.…”

Section: Caries: Processes Of Dental Remineralization and Demineralizmentioning

confidence: 99%

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Efficacy of casein derivate CPP-ACP1

Pereira

Leal

2014

RGO, Rev. Gaúch. Odontol.

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RESUMO ObjetivoFoi conduzida revisão da literatura em busca de ensaios clínicos randomizados in situ e in vivo que avaliassem o papel do complexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo na prevenção de lesões de cárie. MétodosInicialmente, buscou-se identificar na base Pubmed revisões sistemáticas sobre o tema. Foram identificadas duas revisões sistemáticas, que concluíram que a quantidade e qualidade dos ensaios clínicos randomizados são insuficientes para recomendação do uso clínico do produto. Posteriormente, pesquisaram-se ensaios clínicos randomizados in situ e in vivo que não tivessem sido incluídos nas revisões identificadas. ResultadosOs estudos in vivo e in situ tiveram resultados contraditórios. Os estudos in situ indicaram uma maior eficácia do complexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo em relação ao placebo. Já os estudos in vivo demonstraram diferentes. ConclusãoComplexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo apresentou desempenho ora superior, ora equivalente ao placebo; o flúor demonstrou maior eficácia que o complexo de caseína; o complexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo associado ao flúor se mostrou ora melhor, ora equivalente ao placebo. Diante da evidência científica disponível, não se pode generalizar a indicação do complexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo para prevenção de lesões cariosas.

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Section: Systematic Reviewsmentioning

confidence: 99%

Section: Systematic Reviewsmentioning

confidence: 99%

Section: Systematic Reviewsmentioning

confidence: 99%

Section: Caries: Processes Of Dental Remineralization and Demineralizmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of casein derivate CPP-ACP1

Pereira

Leal

2014

RGO, Rev. Gaúch. Odontol.

View full text Add to dashboard Cite

show abstract

“…A more recent meta-analysis study carried out by Yengopal and Mickenautsch, (2009) to investigate whether CPP-ACP has any superior caries-preventive benefit over any other intervention or placebo.…”

Section: Acp)mentioning

confidence: 99%