This article explores the determinants of personal resilience using the case of nurse prescribing in the North West Region of Cameroon. Nurse prescribing has long been identified as a practical solution to the severe shortage of well-trained doctors and high incidence of diseases in developing countries. However, the working conditions of nurses are risky and vulnerable due to major constraints, such as inadequate training, poor reward systems, limited access to medical facilities/equipment and high workloads. Building on the resilience concept and using narrative analysis of in-depth interviews with nurses and nursing managers in public, private and faith-based hospitals, the article develops a framework depicting three interrelated determinants of personal resilience, namely organisational plans and procedures, personal work context and personal perception of an individual employee.The determinants are discussed further and implications for HRD theory and practice is critically examined.