Carnosic acid inhibits the growth of ER-negative human breast cancer cells and synergizes with curcumin

Einbond, Linda Saxe; Wu, Hui‐Lin; Kashiwazaki, Ryota; He, Kan; Roller, Marc; Su, Tao; Wang, Xiaomei; Goldsberry, Sarah

doi:10.1016/j.fitote.2012.07.006

Cited by 75 publications

(68 citation statements)

References 26 publications

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“…Similarly, carnosic acid inhibited cell growth along with G 1 cell whereas a higher dose of 40µg/ml resulted in slight increase of cells in the G 2 phase of cell cycle. In the same way microarray analysis using MDA-MB-468 triple negative breast cancer cells revealed that at 5µg/ml carnosic acid activated expression of three genes involved in xenobiotic metabolism, antioxidant, transport, GSH biosynthesis, signaling and apoptosis related genes and downregulated expression of transcription inhibitors and cell cycle genes.Furthermore this study showed that carnosic acid enhanced the growth inhibitory effect of curcumin on MDA-MB-468 triple negative breast cancer cells[26].Dose and time dependent growth inhibitory effect of carnosic acid was also observed with prostate cancer cells, another hormone dependent cancer besides breast cancer. Antiproliferative effect of carnosic acid was more on PC3 prostate cancer cells (IC 50 of 41.1µM) compared to DU145 cells.…”

supporting

confidence: 51%

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

2015

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supporting

confidence: 51%

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

2015

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“…Moreover, according to our studies on rosemary polyphenols, carnosic acid contributes to the observed cytostatic effect that rosemary extracts exert on HT-29 cells at similar concentrations as those assayed in the present work. In addition, recently published data indicate that carnosic acid exerts a differential effect on the cell cycle as a function of the assayed concentration and the cellular model selected for the study (Einbond et al, 2012), thus providing an explanation for the divergences observed on the type and severity of the effect exerted by the different enriched rosemary extracts.…”

Section: Anti-proliferative Activitymentioning

confidence: 92%

Two-step sequential supercritical fluid extracts from rosemary with enhanced anti-proliferative activity

Sánchez‐Camargo

Valdés

Sullini

et al. 2014

Journal of Functional Foods

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Available online A B S T R A C TPreviously, carnosic acid and carnosol have demonstrated anti-proliferative activity against different types of cancer. To obtain extracts enriched in these two key phenolic compounds, two different processes have been developed in the present work based on the use of two-step sequential supercritical fluid extraction (SFE). By removing the interfering, less active fractions in a first step (150 or 300 bar, 40°C, neat CO2, 60 min), suitable enrichment is achieved in the second step (150 bar, 40°C, CO2 + 7% ethanol, 120 min), and this leads to carnosic acid concentrations in the extract as high as 40% of total dry weight, which are among the highest concentrations that have been described with this type of process. The enriched extracts were tested against the HT-29 human adenocarcinoma cell line, showing enhancement of their antiproliferative activity by approximately 3-fold compared to previously reported SFE rosemary extracts and higher inhibitory effects at lower concentrations (30 µg mL −1 of extract). Thus, the proposed two-step SFE process effectively improves the carnosic acid and carnosol recovery in shorter processing times (180 min vs. 300 min). Moreover, the obtained extracts possess higher anti-proliferative activity and consume less solvent.

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“…In several of these studies, carnosic acid was found to be the most effective compound in relation to this activity (6,31). With regard to the different methodologies of extraction, the use of supercritical fluids resulted more effective than the methanolic extraction in obtaining the bioactive compounds of rosemary and, consistently, these extracts were the most active in inhibiting cell proliferation (6).…”

Section: Rosemary Extract In Breast Cancermentioning

confidence: 98%

“…Regarding its activity on cancer cells, it was demonstrated the antiproliferative effect of rosemary on breast tumor cells by using different types of rosemary extracts, including methanolic, ethanolic, and supercritical extracts (5,6,9,31). In several of these studies, carnosic acid was found to be the most effective compound in relation to this activity (6,31).…”

Section: Rosemary Extract In Breast Cancermentioning

confidence: 99%

Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy

González-Vallinas

Reglero

Molina

2015

Nutrition and Cancer

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Cancer remains an important cause of mortality nowadays and, therefore, new therapeutic approaches are still needed. Rosemary (Rosmarinus officinalis L.) has been reported to possess antitumor activities both in vitro and in animal studies. Some of these activities were attributed to its major components, such as carnosic acid, carnosol, ursolic acid, and rosmarinic acid. Initially, the antitumor effects of rosemary were attributed to its antioxidant activity. However, in recent years, a lack of correlation between antioxidant and antitumor effects exerted by rosemary was reported, and different molecular mechanisms were related to its tumor inhibitory properties. Moreover, supported by the U.S. Food and Drug Administration and the European Food and Safety Authority, specific compositions of rosemary extract were demonstrated to be safe for human health and used as antioxidant additive in foods, suggesting the potential easy application of this agent as a complementary approach in cancer therapy. In this review, we aim to summarize the reported anticancer effects of rosemary, the demonstrated molecular mechanisms related to these effects and the interactions between rosemary and currently used anticancer agents. The possibility of using rosemary extract as a complementary agent in cancer therapy in comparison with its isolated components is discussed.

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Carnosic acid inhibits the growth of ER-negative human breast cancer cells and synergizes with curcumin

Cited by 75 publications

References 26 publications

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

Two-step sequential supercritical fluid extracts from rosemary with enhanced anti-proliferative activity

Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy

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