The effects of different feeds and feeding regimes on growth performance, flesh quality and fecal viscosity of Atlantic salmon (Salmo salar L.) in recirculating aquaculture systems (RAS) were investigated. Fish (initial body weight of 1677 g ± 157 g) were fed with four commercial feeds (Nosan salmon-NS, Aller gold-AG, Skretting salmon-SS and Han ye-HY) in two feeding regimes (80% and 100% satiation) for 78 d. The results showed that salmon specific growth ratio (SGR) and weight gain ratio (WGR) were significantly affected by feed type and feeding regime (P < 0.05). Feed conversion ratio (FCR) varied between 0.93 and 3.40, which was significantly affected by feed type (P < 0.05), and slightly improved with increased satiation degree. The activities of digestive enzymes including protease, lipase and amylase were also significantly affected by feed type and feeding regime (P < 0.05), increasing with satiation degree. Flesh qualities for vitamin E, hydroxyproline (HYP), liquid loss and muscle pH among all groups showed significant differences (P < 0.05), ranging from 26.67 to 29.67, while no obvious difference was found in flesh color. Fecal viscosity for different treatments showed no significant difference, though improvement was found in 100% satiation group. From present experiment, it was concluded that both feed type and feeding regime can affect the important quality attributes of Atlantic salmon.