Carotenoid lutein protects rats from gastric ulcer induced by ethanol

Sindhu, Edakkadath Raghavan; Kuttan, Ramadasan

doi:10.1515/jbcpp-2011-0032

Cited by 21 publications

(16 citation statements)

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“…20 Epidemiological studies revealed a correlation between increased consumption of a diet rich in carotenoids with a reduction in the risk of degenerative disorders, such as cancer, cardiovascular disease, ophthalmological diseases and ulcer. 23 , 24 The protective effect of carotenoids have been associated with their antioxidant activity thereby defending the cells and tissues from oxidative damage. 25 Carotenoids were also shown to be potent antioxidants that enhanced cytoprotection in peptic ulcers and were efficacious in the healing of gastric ulcers.…”

Section: Resultsmentioning

confidence: 99%

Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats

Ofusori

Moodley

Jonnalagadda

2020

Journal of Traditional and Complementary Medicine

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Background and aim Gastric ulcer is a chronic disease and serious health issue. Celosia trigyna is a medicinal plant used traditionally for wound healing. This study aimed to isolate the bioactive compounds from Celosia trigyna and to investigate the in vitro and in vivo anti-ulcerogenic effects of the extract s on ethanol-induced gastric ulcer on adult Wistar rats to determine their regenerative potential. Experimental procedure Seven groups (A – negative control, B – vehicle control, C, D, E, F and G – positive control, n = 5) of five adult Wistar rats received treatment for ethanol-induced gastric ulcer. Results and conclusion Phytochemical analysis led to the isolation of chondrillasterol, lutein, pheophytin a and chondrillasterol acetate. The in vitro results showed dichloromethane and hexane extracts to have maximum chymotrypsin inhibition relative to the standard (chymostatin) while in vivo results showed a significant increase in ulcer parameters of the vehicle control relative to groups treated with plant extracts (P < 0.05). Ulcer parameters and DNA density in groups treated with dichloromethane and hexane extracts were comparable to the negative control. Gross and histopathological findings confirmed gastric mucosa lesions in the vehicle control. There were mild ulcerations in groups treated with the ethyl acetate and methanol extracts with no observable ulcerations in the groups treated with dichloromethane and hexane extracts as the histoarchitectural outlines do not show any form of necrosis, distortion or cellular vacuolation. It was concluded that non-polar, hydrophobic compounds are able to remediate the degree of ulceration but not polar compounds.

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Section: Resultsmentioning

confidence: 99%

Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats

Ofusori

Moodley

Jonnalagadda

2020

Journal of Traditional and Complementary Medicine

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“…Additionally, the L/Zi also includes candles ranging from 14 to 16%. A dosage of 100 mg/kg was selected since many in vivo studies showed that this dosage was antioxidant in rodents [23–25]. …”

Section: Methodsmentioning

confidence: 99%

Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model

et al. 2017

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BackgroundSeveral studies associated high-fat intakes with a high incidence of age-related macular degeneration (AMD). Lutein and Zeaxanthin isomers (L/Zi) may counteract reactive oxygen species produced by oxidative stress. The present study was conducted to determine the possible effects of L/Zi administration on lipid profile, protein genes associated with oxidative stress and inflammation pathways in the obesity induced by a high-fat diet (HFD) in rodents.MethodsTwenty-eight male Wistar rats were allocated into four groups as follows: (i) Control, (ii) Control + L/Zi, (iii) High Fat Diet (HFD), and (iv) HFD+ L/Z. L/Zi was administrated for 8 weeks at a daily dose of 100 mg/kg BW.ResultsL/Zi administration significantly reduced insulin and free fatty acid (FFA) levels (P < 0.001) and ameliorated the oxidative damage by reducing malondialdehyde (MDA) concentration and increasing antioxidant enzymes activities of retina induced by HFD. In addition, supplementation decreased the levels of vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), nuclear factor-kappa B (NF-κB) and intercellular adhesion molecule-1 (ICAM) (P < 0.001, respectively) and improved nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) gene proteins in retinal tissues (P < 0.001).ConclusionRats fed with HFD exhibited increased oxidative stress and upregulation of inflammatory indicators. However, L/Zi supplementation modulates genes involved oxidative stress and inflammation including NF-κB and Nrf2 signaling pathways in the retina which may contribute to ameliorating retinal damage induced by HFD.

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“…In addition to their action as gastroprotective, these antioxidant compounds can be an alternative for the cure of gastric ulcers. 25,26 Results of the current study showed that animals pre-treated with sider and omeprazole considerably reduced ulcer area formation compared to animal group pre-treated with only 5% Tween 80 (vehicle). Sider honey at doses of 100, 250…”

Section: Resultsmentioning

confidence: 59%

Effectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism

Taha¹,

Abdelwahab²,

Elsanousi³

et al. 2015

Phcog J

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Background: Sider (Ziziphus spina-christi (L.) Desf.) Honey has been used for the treatment of gastrointestinal disorders including peptic ulcer. Aim of the study: The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. Materials and methods: Experimental animals were orally treated with sidr honey (100, 250 and 500 mg/kg, respectively) or omeprazole and subsequently exposed to 95%ethanol (5 mL/Kg, orally) to induce acute gastroulcerogenesis. Effectiveness of sidr honey was evaluated using ulcer index, pH of gastric juice, mucus content, morphological analyses, glutathione assay and malondialdehyde level. The anti-apoptotic role of sidr honey was studied using immunohistochemical staining of gastric tissues using monoclonal antibodies of Bax pathway. Results: Dose-response studies in ethanol-induced ulcer indicate that sidr honey significantly blocks gastric lesions at lower dose (100 mg/kg). Lipid peroxidation and glutathione depletion were significantly inhibited by sidr honey. Sidr honey modulated the immuno-expression of mitochondrial associated protein (Bax). Conclusion: Thus, sider honey plays a considerable role in gastro protection by acting as a potent antioxidant and antiapoptotic agent. Future study is required to explore its potential clinical usage.

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Carotenoid lutein protects rats from gastric ulcer induced by ethanol

Cited by 21 publications

References 0 publications

Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats

Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats

Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model

Effectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism

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