Carotenóides como alternativa contra a hipovitaminose A

Ambrósio, Carmem Lygia Burgos; Campos, Fábio; Faro, Zelyta Pinheiro de

doi:10.1590/s1415-52732006000200010

Cited by 73 publications

(68 citation statements)

References 42 publications

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“…(5,(12)(13)(14)(15)(16)(17)(18)(19) The findings of this study demonstrated that A.a. presents characteristics similar to previously reported results on studies of tucumã, even in its various derivative forms in which it was examined. (7,8,19,20) Substances, such as carotenoids and polyphenols found in the oil of tucumã, were previously evaluated by de Rosso and Mercadante, (5) and Gonçalves et al, (8) who associated these compounds with the elimination of free radicals. These affirmations are corroborated with this study, because A.a. is described as rich in carotenoids and flavonoids; both compounds are known as antioxidants in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Tucumã analysis show one of the highest concentrations of pro-vitamin A, representing 52 mg/100 g of pulp, with a potential antioxidant that block the harmful effects caused by free radicals. Carotenoids are essential for cell differentiation, embryonic development, vision, as well as many other functions, including potential therapeutic benefits (5,6) According to Ambrósio et al, (2006), (7) β-carotene is a powerful antioxidant that protects against cardiovascular diseases by inhibiting the oxidative process of low-density lipoprotein (LDL). Important polyphenols, such as quercetin, are also present in tucumã, which is one of the main flavonoids present in the human diet.…”

Section: Introductionmentioning

confidence: 99%

“…Flavonoids are compounds found in plants, which also have antioxidant properties. (7,8) Chemotherapeutic doxorubicin (DXR) is an anthracyclic antibiotic and a potent, broad spectrum, antitumor medicine, frequently used in combination with different medicines in the treatment of acute leukemia, lymphomas and solid tumors, such as breast, ovarian, and endometrial. Its toxicity can be caused in different ways: its planar agglutinated portion can be inserted between adjacent base pairs in the DNA, modifying the ability of nuclear helicases to dissociate the DNA double-strand and the topoisomerase II enzyme.…”

Section: Introductionmentioning

confidence: 99%

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Efeito da Astrocaryum aculeatum (Tucumã) na toxicidade da Doxorrubicina: modelo experimental in vivo

et al. 2017

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Objective: To obtain the oil of Astrocaryum aculeatum (A.a), and evaluate its genotoxicity/antigenotoxicity activities using the micronucleus test in peripheral blood cells. Methods: The oil of Astrocaryum aculeatum was obtained by hydraulic pressing. The animals used were healthy Swiss male mice, at 6-7 weeks of age; there were six per group. The genotoxic and antigenotoxic activity of concentrations were 500, 1,000 and 2,000 mg/kg per 0.5 mL (oral), followed or not followed by intraperitoneal injection of doxorubicin (0.3 mL-15 mg/kg by body weight), in addition to a negative group (water) and dimethyl sulfoxide (600 μL). Peripheral blood samples were collected 24h and 48h after treatment. Results: A statistically significant reduction was identified in the frequency of micronuclei in polychromatic cells ranging from 34.72% to 38.19% for 24-hour treatments, and from 63.70% to 66.12% for 48 hour. Conclusion: The fixed oil of tucumã presented antigenotoxic potential for the concentrations used in acute treatments. ResumoObjetivo: Obter o óleo do Astrocaryum aculeatum (A.a) e avaliar a genotoxidade/antigenotoxidade pelo teste do micronúcleo em células do sangue periférico. Métodos: O óleo da A.a foi obtido por prensagem hidráulica. Os animais foram camundongos Swiss, machos e saudáveis com 6-7 semanas de idade, 6 por grupo. Teste genotóxico e antigenotóxico as concentrações foram de 500, 1.000 e 2.000 mg/kg por 0,5 mL (via oral), seguidas ou não de injeção intraperitoneal de doxorrubicina (0,3mL -15 mg/kg por peso corporal), além do grupo negativo (água) e dimetilsufóxido (600 µL). As amostras de sangue periférico foram coletadas 24h e 48h após o tratamento. Resultados: Houve redução estatisticamente significativa na frequência de micronúcleos em células policromáticas que variou de 34,72% à 38,19% para os tratamentos de 24h, e de 63,70 à 66,12% para os de 48h. Conclusão: O óleo fixo do tucumã apresentou potencial antigenotóxico para as concentrações em tratamentos agudos.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efeito da Astrocaryum aculeatum (Tucumã) na toxicidade da Doxorrubicina: modelo experimental in vivo

et al. 2017

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“…However, the oils extracted from palm fruits have only been characterized spectrophotometrically for their total carotenoid content (Mambrine et al, 1997, Ferreira et al, 1999Fihlo et al, 2013), and these have been considered as potential sources of carotenoids (Manorama et al, 1991;Rodriguez-Amaya, 1996). In fact, the enrichment of foods with natural sources of β-carotene, such as these palm oils, could be an alternative solution to preventing the hypo-vitaminosis A disorder in Brazilian population (Ambrosio et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Carotenoid composition in oils obtained from palm fruits from the Brazilian Amazon

Santos¹,

Alves²,

Roca³

2015

Grasas y Aceites

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SUMMARY:The oils obtained from native palm fruits are considered new sources of high added value phytochemicals, making it necessary to know the composition of the less studied species in order to evaluate their economic potential. The objective of this study is to identify and quantify the carotenoids in palm fruit oils from the Brazilian Amazon: bacaba (Oenocarpus bacaba), buriti (Mauritia flexuosa), inajá (Maximiliana maripa), pupunha (Bactris gasipaes) and tucumã (Astrocaryum vulgare), by means of liquid phase extraction and HPLC-UV-vis. analysis. The results showed an extremely variable carotenoid content, from 13 mg·kg −1 in bacaba oil to more than 1000 mg·kg −1 in the tucumã one. The oils obtained from buriti, pupunha and tucumã displayed high concentrations of ß-carotene, corresponding to fruits with the series ß, ß dominant metabolism. Upon analyzing the carotenoid profile in bacaba oil for the first time, an extraordinary dominance of the ß, ε pathway was observed, proving them to be oils with high lutein and α-carotene contents. Although the ß, ß pathway dominates in inajá oil, the exclusive and high lycopene content implies that LCY-E is barely active in these fruits, in contrast to what has been evidenced so far. It is therefore of the utmost importance to characterize these new potential sources of carotenoids.KEYWORDS: Astrocaryum vulgare; Bactris gasipaes; HPLC-carotenoids; Mauritia flexuosa; Maximiliana maripa; Oenocarpus vacaba; Palm oils RESUMEN: Composición de carotenoides en aceites obtenidos a partir de frutos de palma de la Amazonia Brasileña. Los aceites obtenidos a partir de frutos de palmeras nativas son considerados nuevas fuentes de fitoquímicos con alto valor añadido siendo necesario conocer la composición de las especies menos exploradas para evaluar su potencial económico. El objetivo de este estudio es identificar y cuantificar los carotenoides en aceites defrutos de palmeras provenientes de la Amazonia Brasileña: bacaba (Oenocarpus bacaba), buriti (Mauritia flexuosa), inajá (Maximiliana maripa), pupunha (Bactris gasipaes) y tucumã (Astrocaryum vulgare), mediante extracción líquido:líquido y análisis por HPLC-UV-vis. Los resultados mostraron un contenido de carotenoides muy variable, entre 13 mg·kg −1 en el aceite de bacaba y superior a 1000 mg·kg −1 en el aceite de tucumá. Los aceites procedentes de buriti, pupunha y tucumã presentaron altas concentraciones de ß-caroteno, correspondiendo a frutos con metabolismo dominante de la serie ß, ß. Al analizar por primera vez el perfil carotenoides del aceite de bacaba se observó una excepcional dominancia de la ruta ß, ε, y consecuentemente presenta un alto contenido en luteína y α-caroteno. Aunque en los aceites de inajá predomina la ruta ß, ß, el exclusivo y alto contenido de licopeno implica que LCY-E es muy poco activa en estos frutos, a diferencia de lo descrito hasta el momento. Resulta pues fundamental caracterizar estas nuevas potenciales fuentes de carotenoides.

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“…São responsáveis pelas cores das folhas e dos frutos (Britton et al, 2004;Ambrósio et al, 2006). Cerca de 50 carotenoides possuem atividade pró-vitamina A. O betacaroteno é o que apresenta maior atividade pró-vitamínica.…”

Section: Introductionunclassified

Variabilidade de genótipos de milho quanto à composição de carotenoides nos grãos

Cardoso

Paes

Galvão

et al. 2009

Pesq. agropec. bras.

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Resumo -O objetivo deste trabalho foi caracterizar e avaliar a variabilidade quanto ao teor e perfi l de carotenoides nos grãos de 134 genótipos de milho (Zea mays), com vistas à utilização em programas de biofortifi cação. Os materiais foram provenientes dos campos experimentais e do Banco Ativo de Germoplasma da Embrapa Milho e Sorgo, Sete Lagoas, MG. São cultivares e híbridos comerciais, linhagens-elite e outros acessos escolhidos com base na coloração amarelo-alaranjada do endosperma. A quantifi cação do teor de carotenoides totais, carotenos e xantofi las mono-hidroxilada e di-hidroxilada dos grãos foi realizada por método cromatográfi coespectrofotométrico. As médias encontradas nos grãos foram 22,34 µg g -1 de carotenoides totais, 2,55 µg g -1 de carotenos, 3,86 µg g -1 de xantofi las mono-hidroxiladas e 15,93 µg g -1 de xantofi las di-hidroxiladas. Os genótipos foram agrupados em 18 grupos pelo método de Tocher. O germoplasma da Embrapa possui potencial para ser usado em programas de desenvolvimento de linhagens de milho biofortifi cadas, quanto ao total de carotenoides pró-vitamina A.Termos para indexação: Zea mays, biofortifi cação, carotenoides, melhoramento, vitamina A. Variability of maize genotypes for grain carotenoid compositionAbstract -The objective of this work was to characterize 134 maize (Zea mays) genotypes, for carotenoids content and build a genetic profi le to facilitate future breeding to increase grain nutritional value (biofortifi cation). Seeds came from experimental fi elds and from the Banco Ativo de Germoplasma of Embrapa Milho e Sorgo, Sete Lagoas, MG, Brazil. The genotypes were commercial hybrids, varieties, and inbred lines developed by the Embrapa biofortifi cation program and other accessions, chosen for their yellow-orange endosperm color. Total grain carotenoids, carotenes, xanthophylls (monohydroxylates and dihydroxylates) were determined by chromatographic-spectrophotometric methods. The detected averages were: 22.34 µg g -1 for total carotenoids, 2.55 µg g -1 for carotenes, 3.86 μg g -1 for monohydroxylated xanthophylls, and 15.93 µg g -1 for dihydroxylated xanthophylls. The genotypes variability was divided into 18 groups by the method of Tocher. The Embrapa germplasm has variability and potential for development of maize lines biofortifi ed for total of provitamin A carotenoids.

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Carotenóides como alternativa contra a hipovitaminose A

Cited by 73 publications

References 42 publications

Efeito da Astrocaryum aculeatum (Tucumã) na toxicidade da Doxorrubicina: modelo experimental in vivo

Efeito da Astrocaryum aculeatum (Tucumã) na toxicidade da Doxorrubicina: modelo experimental in vivo

Carotenoid composition in oils obtained from palm fruits from the Brazilian Amazon

Variabilidade de genótipos de milho quanto à composição de carotenoides nos grãos

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