Carotenoids production from a newly isolated Sporidiobolus pararoseus strain by submerged fermentation

Cabral, Maria Marina Serrão; Cence, Karine; Zeni, Jamile; Tsai, Sui Mui; Durrer, Ademir; Foltran, Lillian Liva; Toniazzo, Geciane; Valduga, Eunice; Treichel, Helen

doi:10.1007/s00217-011-1510-0

Cited by 30 publications

(26 citation statements)

References 39 publications

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“…This medication improves mental and physical conditions of patients and reduces the risk of diseases such as HIV/AIDS and hepatitis (20,21). According to studies, this method of treatment decreased mortality resulted from overdose, prevented withdrawal syndrome (22,23) and re-incarceration (24,25), and inhibited crimes initiated by illegal drug abuse; as a result, it provided infected people with the chance to improve their social health and life and involve in productive activities (26)(27)(28)(29)(30) …”

Section: Key Messagesmentioning

confidence: 99%

Methadone maintenance treatment program in prisons from the perspective of medical and non-medical prison staff: a qualitative study in Iran

Moradi

Farnia²,

Shokoohi

et al. 2015

Int J Health Policy Manag

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Background: As one of the most important components of harm reduction strategy for high-risk groups, following the HIV epidemics, Methadone Maintenance Treatment (MMT) has been initiated in prisoners since 2003. In this paper, we aimed to assess the advantages and shortcomings of the MMT program from the perspective of people who were involved with the delivery of prison healthcare in Iran. Methods: On the basis of grounded theory and through conducting 14 Focus Group Discussions (FGDs), 7 FGDs among physicians, consultants, experts, and 7 FGDs among directors and managers of prisons (n= 140) have been performed. The respondents were asked about positive and negative elements of the MMT program in Iranian prisons.Results: This study included a total of 48 themes, of which 22 themes were related to advantages and the other 26 were about shortcomings of MMT programs in the prisons. According to participants' views "reduction of illegal drug use and high-risk injection", "reduction of potentially high-risk behaviors" and "making positive attitudes" were the main advantages of MMT in prisons, while issues such as "inaccurate implementation", "lack of skilled manpower" and "poor care after release from prison" were among the main shortcomings of MMT program. Conclusions: MMT program in Iran's prisons has achieved remarkable success in the field of harm reduction, but to obtain much more significant results, its shortcomings and weaknesses must be also taken into account by policy-makers.

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Section: Key Messagesmentioning

confidence: 99%

Methadone maintenance treatment program in prisons from the perspective of medical and non-medical prison staff: a qualitative study in Iran

Moradi

Farnia²,

Shokoohi

et al. 2015

Int J Health Policy Manag

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“…Rise in consumers' health awareness has made them seek functional foods, a fact that may trigger an increase in the demand for carotenoids in the food industry (5). The global market demand for carotenoids has grown 2.9 % per year (6) and is expected to reach almost 10 million tons by 2017 (7).…”

Section: Introductionmentioning

confidence: 99%

“…The global market demand for carotenoids has grown 2.9 % per year (6) and is expected to reach almost 10 million tons by 2017 (7). However, most of the commercial carotenoids derive from chemical synthesis and cannot meet consumers' demands for natural carotenoids (5). Due to concerns over the use of chemical additives in food, there has been an increasing interest in carotenoids that are naturally obtained by biotechnological processes.…”

Section: Introductionmentioning

confidence: 99%

Raw Glycerol and Parboiled Rice Effluent for Carotenoid Production: Effect of the Composition of Culture Medium and Initial pH

Silva¹,

Borba²,

Kalil³

et al. 2016

Food Technol. Biotechnol.

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SummarySearch for naturally grown food has stimulated the biotechnological production of carotenoids. Therefore, the use of the yeast Xanthophyllomonas dendrorhous has been researched due to its abilities to assimilate diff erent sources as substrates and to produce high amounts of carotenoids. Furthermore, alternative sources have been used as the culture medium to reduce costs and environmental impact. A potent carotenoid is astaxanthin in view of its health-promoting and antioxidative properties. It consists of diff erent geometrical isomers with trans and cis confi guration. In X. dendrorhous this carotenoid is mostly found in the trans form, but cis isomers can also be found. Carotenoid production was investigated in culture medium containing by-products such as raw glycerol (from biodiesel) and parboiled rice effl uent. The eff ects of the culture medium components on biomass concentration and specifi c and volumetric productions of carotenoids were verifi ed by the Plackett -Burman design. Cultivations were carried out with yeast Xanthophyllomonas dendrorhous NRRL Y-17268 at 25 °C and 150 rpm for 168 h. In this study, maximum production of carotenoids was obtained under the following conditions (in g/L): raw glycerol 10, glucose 10, yeast extract 10, malt extract 10 and peptone 1 at pH=6. Resulting specifi c and volumetric productions of carotenoids were 326.8 and 4.1 μg/g, respectively.

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“…Among these, astaxanthin, an oxygenated carotenoid that has a typical orange-pink color, is widely distributed in nature, presenting biological functions that have attracted increasing interest. The largest source of this carotenoid is the alga Haematococcus pluvialis, but it can also be produced by various yeasts, being the main carotenoid synthesized by the yeast Xanthophyllomyces dendrorhous, popularly known as Phaffia rhodozyma (Domínguez-Bocanegra; Ponce-Noyola; Torres-Muñoz, 2007;Rodriguez-Saiz;Fuente;Barredo, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…A significant increase in carotenoid production by various microorganisms has been observed with the use of the methodology of factorial design to evaluate different means of production, culture conditions, such as pH, temperature, aeration, and inoculum concentration, and recovery of these compounds (Ni et al, 2007;Liu;Wu, 2007;Gu et al, 2008;Ni et al, 2008;Valduga et al, 2011;Cabral et al, 2011;Michelon et al, 2012). In previous work conducted by our research group, the use of a culture medium containing rice parboiling wastewater (15 g L -1…”

Section: Introductionmentioning

confidence: 99%

RICE PARBOILING WASTEWATER IN THE MAXIMIZATION OF CAROTENOIDS BIOPRODUCTION BY Phaffia rhodozyma

et al. 2015

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The interest in carotenoid production from natural sources has increased based in their possible use as dyes and their powerful biological antioxidant capacity. This study evaluated the use of rice parboiling wastewater (RPW) as an alternative substrate for the bioproduction of carotenoids using the yeast Phaffia rhodozyma and found it to be promising as the only source of nutrients, reaching a concentration of 0.6 μg mL -1 (259.1 μg g -1 ) in 48 h. To increase the potential use of this industrial effluent, a study of supplementation was carried out to enhance the production of carotenoids using the methodology of experimental design (a 2 IV 6-2 fractional factorial design sequenced by a 2 4 central composite design). The conditions for maximizing the production of carotenoids were (g L -1) malt extract (16.25), peptone (8.75), sucrose (15) and rice parboiling wastewater (87.5), with a pH of 5 at 25 °C and 150 rpm for 144 h, which produced a concentration 5.3 μg mL -1 (628.8 μg g -1 ).Index terms: Biodye; submerged cultive; response surface methodology; yeast. RESUMOO interesse pela produção de carotenoides por fontes naturais é crescente, em decorrência da possibilidade de atuar como corante e sua capacidade antioxidante biológica potente. Neste estudo, avaliou-se o uso da água de parboilização do arroz, como substrato alternativo para a bioprodução de carotenoides, usando a levedura Phaffia rhodozyma que, como única fonte de nutrientes, foi promissora, alcançando 0,6 µg mL -1 (259,1 µg g -1

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Carotenoids production from a newly isolated Sporidiobolus pararoseus strain by submerged fermentation

Cited by 30 publications

References 39 publications

Methadone maintenance treatment program in prisons from the perspective of medical and non-medical prison staff: a qualitative study in Iran

Methadone maintenance treatment program in prisons from the perspective of medical and non-medical prison staff: a qualitative study in Iran

Raw Glycerol and Parboiled Rice Effluent for Carotenoid Production: Effect of the Composition of Culture Medium and Initial pH

RICE PARBOILING WASTEWATER IN THE MAXIMIZATION OF CAROTENOIDS BIOPRODUCTION BY Phaffia rhodozyma

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