Carotid Artery Atherosclerosis: In Vivo Morphologic Characterization with Gadolinium-enhanced Double-oblique MR Imaging—Initial Results

Wasserman, Bruce A.; Smith, William I.; Trout, Hugh H.; Cannon, Richard O.; Balaban, Robert S.; Arai, Andrew E.

doi:10.1148/radiol.2232010659

Cited by 306 publications

(245 citation statements)

References 23 publications

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“…Previous work has shown excellent contrast between the cap and core with imaging at 5 minutes following injection (13). There does not appear to be a gain in CNR beyond the first 10 minutes following gadolinium administration.…”

Section: Discussionmentioning

confidence: 73%

“…The cap was identified as an area of relative hyperintensity adjacent to the lumen, and the lipid core as an area hypointense and deep to the cap on T2-weighed images. The delineation of the cap and core was confirmed using the T1-weighted postcontrast DIR FSE sequence when acquired, with the cap appearing hyperintense relative to the core (13). The ROIs were copied from these images onto the IR FSE images (Fig.…”

Section: Image Analysismentioning

confidence: 99%

“…However, T2-weighted images have inherently low signal, making plaque component delineation difficult. Wasserman et al (13) showed that the use of a gadoliniumbased contrast agent helped discriminate the fibrous cap from the lipid core with a contrast-to-noise ratio (CNR) as good as or better than that with T2-weighted MR images, but with approximately twice the signal-tonoise ratio (SNR). Yuan et al (14) reported similar results.…”

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confidence: 99%

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Wash‐in kinetics for gadolinium‐enhanced magnetic resonance imaging of carotid atheroma

Wasserman

Casal

Astor

et al. 2004

Magnetic Resonance Imaging

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Purpose:To determine the wash-in kinetics of intravenous gadolinium into the fibrous cap and lipid core of carotid atheroma, and identify the time following gadolinium administration that maximizes contrast between the cap and core. Materials and Methods:Seven subjects with carotid artery stenosis were studied. Magnetic resonance (MR) images of the atheroma were acquired using a single-inversion-recovery fast-spin-echo (IR FSE) sequence, which was serially repeated during the first 30 minutes following intravenous gadolinium administration. Postcontrast time was divided into three intervals: Ͻ10, 11-20, and Ͼ21 minutes. Adjusted signal intensity (SI), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) values for postcontrast images were compared to adjusted precontrast values. Results:The mean SNRs of the cap and core were significantly elevated in each postcontrast interval compared with mean precontrast values. The CNRs of the cap vs. the core increased by 19.8% (3.03 to 4.14, P ϭ 0.03) in the first 10 minutes following gadolinium administration, and remained elevated over the next two intervals with a slight decrease in the final interval. Conclusion:Increased signal and contrast between the cap and core can be achieved by imaging up to 30 minutes following gadolinium administration, with peak enhancement occurring in the first 10 minutes.

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Section: Discussionmentioning

confidence: 73%

Section: Image Analysismentioning

confidence: 99%

mentioning

confidence: 99%

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Wash‐in kinetics for gadolinium‐enhanced magnetic resonance imaging of carotid atheroma

Wasserman

Casal

Astor

et al. 2004

Magnetic Resonance Imaging

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“…4 and references therein), multiple sclerosis (5), rheumatoid arthritis (6), atherosclerosis (7,8), Crohn's disease (9) and other inflammatory conditions (10), and are potentially able to provide information concerning the blood volume of the tissue, microvessel permeability, and lesion interstitial space. These parameters may be extracted from a DCE-MRI time course via the application of models that describe the distribution of contrast agent in vivo.…”

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confidence: 99%

Comparative study into the robustness of compartmental modeling and model‐free analysis in DCE‐MRI studies

Roberts

Issa

Stone

et al. 2006

Magnetic Resonance Imaging

147

111

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Purpose: To evaluate and compare the reproducibility of the preferred phenomenological parameter IAUC 60 (initial area under the time-concentration curve [IAUC] defined over the first 60 seconds postenhancement) with the preferred modeling parameter (K trans ), as derived using two simple models, in abdominal and cerebral data collected in typical Phase I clinical trial conditions. Materials and Methods:Dynamic contrast enhanced MRI (DCE-MRI) time series were acquired at two imaging centers from a group of patients with abdominal tumors and a group with gliomas. At both imaging centers, precontrast T 1 was calculated using a variable flip angle three-dimensional spoiled gradient echo acquisition that was used to quantify tissue contrast agent concentration, allowing voxelwise definition of summary DCE-MRI parameters.Results: A comparison of reproducibility showed that there was no statistically significant difference in reproducibility between IAUC 60 and K trans , although there was a trend towards better reproducibility for K trans (P ϭ 0.0782). The 95% confidence intervals (CIs) for individual changes showed that for IAUC 60 and K trans , changes in excess of 47% and 31%, respectively, are outside the range of normal variability. Conclusion:Although modeling is more complex and more computationally intensive than an IAUC parameterization, our data suggest this approach to be preferable to a modelfree approach since it provides greater physiological insight without a reduction in statistical power for Phase I/II clinical drug trials.

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“…In past decades, there has been considerable progress in MR scanning technology and parameters, including the development of multicontrast MR protocols 73, 74, 75. Furthermore, image acquisition time, success rate, the demonstration of calcification, and the diagnostic accuracy of cardiac magnetic resonance angiography have all steadily improved 76, 77, 78, 79, 80…”

Section: Multimodality Imaging Techniquesmentioning

confidence: 99%

Imaging Cardiovascular Calcification

Wang

Osborne

Tung

et al. 2018

JAHA

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Carotid Artery Atherosclerosis: In Vivo Morphologic Characterization with Gadolinium-enhanced Double-oblique MR Imaging—Initial Results

Cited by 306 publications

References 23 publications

Wash‐in kinetics for gadolinium‐enhanced magnetic resonance imaging of carotid atheroma

Wash‐in kinetics for gadolinium‐enhanced magnetic resonance imaging of carotid atheroma

Comparative study into the robustness of compartmental modeling and model‐free analysis in DCE‐MRI studies

Imaging Cardiovascular Calcification

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