Carotid Artery Elasticity and Baroreflex Sensitivity in Patients With Glaucoma

Visontai, Zsuzsanna; Mersich, Beatrix; Holló, Gábor

doi:10.1097/01.ijg.0000145814.46848.76

Cited by 14 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arterial stiffness is considered an independent predictor of cardiovascular disease, 65 and increased IMT has been suggested as an indirect measure of generalized atherosclerosis and cardiovascular risk. 66 The presence of cardiovascular disease and structural vascular wall changes has been variably linked to the presence of GON during recent years, with some studies identifying strong associations in POAG [67][68][69] and NTG 39,70,71 patients individually and others revealing no such associations. [72][73][74][75] The variability in results between these previous studies could in part be accounted for by differences in the inclusion/exclusion of patients with already diagnosed systemic vascular disease, especially because arterial stiffness is a measure of vascular function.…”

Section: Commentmentioning

confidence: 99%

Primary Open-Angle Glaucoma vs Normal-Tension Glaucoma

et al. 2013

View full text Add to dashboard Cite

Section: Commentmentioning

confidence: 99%

Primary Open-Angle Glaucoma vs Normal-Tension Glaucoma

et al. 2013

View full text Add to dashboard Cite

“…[30][31][32][33][34] In a previous study using this technique we were able to identify increased arterial stiffness and decreased baroreflex function in juvenile and primary open angle glaucoma. 35 In the present study, in order to investigate systemic arterial function in XFS/XFG, using the ultrasound wall tracking system we measured end diastolic diameter and pulsatile distension of the common carotid artery, and calculated baroreflex sensitivity (BRS) in XFS/XFG patients and in normal control subjects of similar age. In addition, we tried to identify possible relations between BRS, age, and plasma homocysteine concentration in the two groups of subjects.…”

mentioning

confidence: 99%

Increase of carotid artery stiffness and decrease of baroreflex sensitivity in exfoliation syndrome and glaucoma

Visontai

Merisch

Kollai

et al. 2006

British Journal of Ophthalmology

View full text Add to dashboard Cite

Aim: To investigate the distensibility of the common carotid artery (CCA), baroreflex sensitivity (BRS) and its relation to plasma homocysteine concentration in exfoliation syndrome or exfoliation glaucoma (XFS/XFG). Methods: Homocysteine concentrations were measured in 30 XFS/XFG patients and 18 age matched controls. In 21 patients and 17 controls the end diastolic diameter of the CCA and pulsatile distension were measured and BRS was calculated.Results: There was no significant difference between the groups in sex distribution, age, heart rate, blood pressure, systemic diseases, or medication. In XFS/XFG patients homocysteine concentration was significantly elevated (unpaired t test, p = 0.023), and CCA stiffness was higher (p,0.05), while strain, cross sectional compliance coefficient, distensibility, and BRS were significantly reduced compared to the controls (Mann-Whitney U test, p(0.013 for each parameter). In XFS/XFG patients a positive correlation was found between age and plasma homocysteine level (Pearson's correlation, r = 0.490, p = 0.007), and a negative correlation between age and BRS (Kendall's correlation r = 20.374, p = 0.021), as well as between homocysteine concentration and BRS (Kendall's correlation r = 20.377, p = 0.024). No correlation was seen between these variables in the control group. Conclusions: These results suggest a pathological large artery function as well as altered parasympathetic vascular control in XFS/XFG which increases with age and with higher homocysteine concentration.

show abstract

“…The Rotterdam study reported that hightension or normal-tension OAG is related to high pulse pressure, low diastolic perfusion pressure and high diastolic BP (13). Chronic OAG is associated with increased arterial rigidity and decreased baroreflex function (44). Derived central BP is not altered in glaucoma, but a reduced pulse pressure was identified (7).…”

Section: Discussionmentioning

confidence: 99%

“…The effect of arterial stiffness components has been investigated in certain other ophthalmic disorders, mainly in glaucoma (7,9,13,28,30,32,36,37,44) but not in refractory disorders. Several studies have shown impaired vascular endothelial function in patients with normal-tension glaucoma (NTG) reporting that atherosclerotic cerebrovascular disease involves the eye vasculature by small artery occlusion and therefore, it is a risk factor for having glaucomatous optic disk appearance (9,36).…”

Section: Discussionmentioning

confidence: 99%

Genetic effects on refraction and correlation with hemodynamic variables: A twin study

Toth¹,

Tárnoki²,

Tárnoki³

et al. 2014

Acta Physiologica Hungarica

View full text Add to dashboard Cite

Spherical equivalent (SE) has not been linked to increased cardiovascular morbidity. Methods: 132 Hungarian twins (age 43.3±16.9 years) underwent refraction measurements (Huvitz MRK-3100 Premium AutoRefractokeratometer) and oscillometry (TensioMed Arteriograph). Results: Heritability analysis indicated major role for genetic components in the presence of right and left SE (82.7%, 95%CI, 62.9 to 93.7%, and 89.3%, 95%CI, 72.8 to 96.6%), while unshared environmental effects accounted for 17% (95%CI, 6.3% to 37%), and 11% (95%CI, 3.4% to 26.7%) of variations adjusted for age and sex. Bilateral SE showed weak age-dependent correlations with augmentation index (AIx), aortic pulse wave velocity (r ranging between 0.218 and 0.389, all p < 0.01), aortic systolic blood pressure and pulse pressure (r between 0.188 and 0.289, p < 0.05). Conclusions: These findings support heritability of spherical equivalent, which does not coexist with altered hemodynamics (e.g. accelerated arterial aging). Accordingly, SE and the investigated hemodynamic parameters seem neither phenotypically nor genetically associated.Keywords: arterial stiffness, augmentation index, genetics, heritability, refractionThe first "twin study" was published in 1922 by Walter Jablonski, the first ophthalmologist who used both monozygotic and dizygotic twins to examine the factors that determine the development of the refraction of the eye. He declared "the smaller differences are seen in the majority of monozygotic cases, while larger differences occur in dizygotic cases" (23).Since then, numerous articles discussed the role of inheritance, the genetic predisposition and the gene-environment interactions taking part in the formation of the refractive characteristics of the eye confirming that genetic factors account for 77-94% of the genetic variance (10,25,26,43). However, a similar study in a wide-age range sample is still needed. In addition, despite heritability of refraction was thoroughly investigated in the studies *These authors contributed equally to this work.

show abstract

Carotid Artery Elasticity and Baroreflex Sensitivity in Patients With Glaucoma

Cited by 14 publications

References 35 publications

Primary Open-Angle Glaucoma vs Normal-Tension Glaucoma

Primary Open-Angle Glaucoma vs Normal-Tension Glaucoma

Increase of carotid artery stiffness and decrease of baroreflex sensitivity in exfoliation syndrome and glaucoma

Genetic effects on refraction and correlation with hemodynamic variables: A twin study

Contact Info

Product

Resources

About