Carotid artery intima‐media thickness and angiotensin‐converting enzyme gene polymorphism in the offspring of parents with premature stroke

Varda, Nataša Marčun; Peterlin, Borut; Bradač, S. Umek; Gregorič, Alojz

doi:10.1080/08035250410033943

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Several studies have investigated genetic polymorphisms in candidate pathways implicated in the pathogenesis of atherosclerosis [43][44][45][46][47][48][49][50][51][52][53]. For instance, functional variants in the genes APO A-E [44,45,50], eNOS [47], PCK1 [48], PON1 [49], OPG [53], PPARG [52], and GPx-1 [51] are associated with carotid IMT or its risk factors.…”

Section: Discussionmentioning

confidence: 99%

Heritability of carotid intima-media thickness: A twin study

Zhao¹,

Cheema²,

Bremner³

et al. 2008

Atherosclerosis

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Objective-To estimate the heritability of carotid intima-media thickness (IMT), a surrogate marker for atherosclerosis, independent of traditional coronary risk factors.Methods and Results-We performed a classical twin study of carotid IMT using 98 middleaged male twin pairs, 58 monozygotic (MZ) and 40 dizygotic (DZ) pairs, from the Vietnam Era Twin Registry. All twins were free of overt cardiovascular disease. Carotid IMT was measured by ultrasound. Bivariate and multivariate analyses were used to determine the association between traditional cardiovascular risk factors and carotid IMT. Intraclass correlation coefficients and genetic modeling techniques were used to determine the relative contributions of genes and environment to the variation in carotid IMT. In our sample, the mean of the maximum carotid IMT was 0.75 ± 0.11. Age, systolic blood pressure and HDL were significantly associated with carotid IMT. The intraclass correlation coefficient for carotid IMT was larger in MZ (0.66; 95% confidence interval [CI], 0.62-0.69) than in DZ twins (0.37; 95% CI, 0.29-0.44), and the unadjusted heritability was 0.69 (95% CI, 0.54-0.79). After adjusting for traditional coronary risk factors, the heritability of carotid IMT was slightly reduced but still of considerable magnitude (0.59; 95% CI, 0.39-0.73).Conclusion-Genetic factors have a substantial influence on the variation of carotid IMT. Most of this genetic effect occurs through pathways independent of traditional coronary risk factors.

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Section: Discussionmentioning

confidence: 99%

Heritability of carotid intima-media thickness: A twin study

Zhao¹,

Cheema²,

Bremner³

et al. 2008

Atherosclerosis

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“…Such interaction was also described in children [13]. Other recent work concluded that determination of the ACE insertion/deletion polymorphism and carotid IMT did not help to discriminate the cardiovascular risk in the children of parents with or without premature stroke [14].…”

Section: Angiotensin-converting Enzyme and Coronary Artery Diseasementioning

confidence: 94%

Genetic variants predisposing to cardiovascular disease

Visvikis‐Siest

Marteau

2006

Current Opinion in Lipidology

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During the last year, tremendous effort has been made in elucidating new genes associated with cardiovascular disease predisposition. For the most part, however, major breakthroughs have not been made, primarily due to the poor replication of results among studies, as a consequence of poor experimental design. Nevertheless, we have increased our understanding of the complexity of cardiovascular disease and the relevance of gene-environment interactions as the ultimate drivers of the individual predisposition to the disease. It is essential, therefore, that present and future genetic studies in this area take into consideration the inclusion of high-quality environmental data in the analytical process to test the clinical usefulness of a genetic marker as a risk predictor.

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“…ACE gene polymorphisms have been widely studied in stroke, after the report of increased risk of myocardial infarction in DD genotype carriers [Cambien et al, 1992]. We found three meta-analysis and 12 case-control studies (Table 4) [Casas et al, 2004;Banerjee et al, 2007;Ariyaratnam et al, 2007;Szolnoki et al, 2003;Karagiannis et al, 2004;Zhang et al, 2004;Varda et al, 2005;Brenner et al, 2005;Szolnoki et al, 2005;Dikmen et al, 2006aPera et al, 2006;Gormley et al, 2007;Lalouschek et al, 2007, Berger et al, 2007 on this subject. The meta-analysis of Casas et al [2004] reported an increased risk of stroke in D/D carriers.…”

Section: Platelet Receptorsmentioning

confidence: 99%

Genetic polymorphisms for the study of multifactorial stroke

Bersano¹,

Ballabio²,

Bresolin³

et al. 2008

Hum. Mutat.

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Single-gene disorders explain only a minority of stroke cases. Stroke represents a complex trait, which is usually assumed to be polygenic. On this topic, the role of a wide number of candidate genes has been investigated in stroke through association studies, with controversial results. Therefore, it is difficult for the clinician to establish the validity and the level of clinical applicability of the previously reported associations between genetic factors and stroke. This review is an update and an extensive analysis of the more recent association studies conducted in stroke. We evaluated a number of studies on several candidate genes (including F5, F2, FGA/FGB/FGG, F7, F13A1, vWF, F12, SERPINE1, ITGB3/PLA1/PLA2/ITGA2B, ITGA2, GP1BA, ACE, AGT, NOS3, APOE, LPL, PON1, PDE4D, ALOX5AP, MTHFR, MTR, and CBS), providing a final panel of genes and molecular variants. We categorized this panel in relation to the degree of association with stroke, supported by the results of meta-analyses and case-control studies. Our findings could represent a useful tool to address further molecular investigations and to realize more detailed meta-analyses.

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Carotid artery intima‐media thickness and angiotensin‐converting enzyme gene polymorphism in the offspring of parents with premature stroke

Abstract: We conclude that determination of the carotid IMT and of the ACE I/D polymorphism do not permit discrimination of the cardiovascular risk in children of parents with or without premature stroke.

Cited by 4 publications

References 26 publications

Heritability of carotid intima-media thickness: A twin study

Heritability of carotid intima-media thickness: A twin study

Genetic variants predisposing to cardiovascular disease

Genetic polymorphisms for the study of multifactorial stroke

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