Carotid Atherosclerosis, Endothelial Disfunction, and Arterial Stiffness in Young and Middle-Aged Men with Coronary Artery Disease

Kozlov, Sergey; Balachonova, Tatyana; Machmudova, Heda; Tripoten, M I; Andreevskaya, M.; Rogoza, A. N.; Kuharchuk, Valery

doi:10.1155/2012/950130

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…Among patients with diagnosed coronary artery disease, 56.3% patients had raised CIMT, 74.8% patients had carotid plaques, and 8.4% patients had stenosis in carotid arteries (86). Patients with coronary artery disease more often had multiple plaques (86.7% versus 13.8%, P<0.001) (87). This suggests that coronary artery disease may be an early marker of carotid atherosclerosis.…”

Section: Discussionmentioning

confidence: 97%

Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review

Ji¹,

Leng²,

Dong³

et al. 2019

Ann. Transl. Med.

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Background: Carotid atherosclerosis is a major cause of stroke, but the conclusion about risk factors for carotid atherosclerosis is still controversial. The aim of our present meta-analysis and systematic review was to explore the modifiable risk factors for carotid atherosclerosis. Methods:We searched PubMed from January 1962 to October 2018 to include longitudinal and crosssectional studies. The results were pooled using random effects model. Heterogeneity was measured by I 2 statistic and publication bias was assessed by funnel plots.Results: A total of 14,700 articles were screened, of which 76 with 27 factors were eligible. Our metaanalysis of cross-sectional studies indicated nine factors (hyperlipidemia, hyperhomocysteinemia, hypertension, hyperuricemia, smoking, metabolic syndrome, hypertriglyceridemia, diabetes, and higher low density lipoprotein) were significantly associated with the presence of carotid plaque, among which four (hyperlipidemia, hyperhomocysteinemia, hypertension, and hyperuricemia) could elevate the risk of atherosclerosis by at least 50%; and one factor (hypertension) was associated with increased carotid intimamedia thickness. In the systematic review, another five factors [negative emotion, socioeconomic strain, alcohol, air pollution, and obstructive sleep apnea syndrome (OSAS)] were also related to the presence of atherosclerosis. The cross-sectional associations with most of the above 14 factors were further confirmed by longitudinal studies. Among them, the managements of 4 factors (hypertension, hyperlipidemia, diabetes and OSAS) were indicated to prevent carotid atherosclerosis by cohort studies.Conclusions: Effective interventions targeting pre-existing disease, negative emotion, lifestyle and diet may reduce the risk of carotid atherosclerosis. Further good-quality prospective studies are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 97%

Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review

Ji¹,

Leng²,

Dong³

et al. 2019

Ann. Transl. Med.

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“…Therefore, non-invasive evaluation for endothelial dysfunction, such as FMV, are important tools to determine the association of endothelial dysfunction with wall thickness of conduit vessels, changes of pulse wave velocity and early cardiovascular risk predictors. In fact, these methods have been considered as complementary methods of the current evaluation guidelines for preventing CVD ( Kozlov et al, 2012 ). Also the evaluation of endothelial dysfunction during pregnancy could be a potent tool in the prevention of CVD in early stages of development or in mothers that suffer pregnancy pathologies such as pregnant hypertension, preeclampsia, or GDM ( Escudero and Sobrevia, 2008 ; Escudero et al, 2013 ).…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation

Rodríguez

González

2014

Front. Pharmacol.

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Physiological vascular function regulation is essential for cardiovascular health and depends on adequate control of molecular mechanisms triggered by endothelial cells in response to mechanical and chemical stimuli induced by blood flow. Endothelial dysfunction is one of the main risk factors of cardiovascular pathology, where the imbalance between the synthesis of vasodilator and vasoconstrictor molecules is common in the development of vascular disorders in systemic and placental circulation. In the placenta, an organ without autonomic innervations, the local control of vascular tone is critical for maintenance of fetal growth and mechanisms that underlie shear stress response induced by blood flow are essential during pregnancy. In this field, shear stress induced by moderate exercise is one of the most important mechanisms to improve vascular function through nitric oxide synthesis and stimulation of mechanical response of endothelial cells triggered by ion channels, caveolae, endothelial NO synthase, and vascular endothelial growth factor, among others. The demand for oxygen and nutrients by tissues and organs, especially in placentation and pregnancy, determines blood flow parameters, and physiological adaptations of vascular beds for covering metabolic requirements. In this regard, moderate exercise versus sedentarism shows potential benefits for improving vascular function associated with the enhancement of molecular mechanisms induced by shear stress. In this review, we collect evidence about molecular bases of physiological response to shear stress in order to highlight the relevance of moderate exercise-training for vascular health in adult and fetal life.

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“…Our findings support the notion that sleep instability is associated with higher vascular damage measured as AS and not as EF. 14 This result underlines the impact of sleep quality evaluation in stroke patients and the importance of a proper sleep diagnosis in this high-risk population.…”

Section: Discussionmentioning

confidence: 70%

Endothelial Dysfunction and Arterial Stiffness in Ischemic Stroke

Cereda

Tamisier

Manconi

et al. 2013

Stroke

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Endothelial function (EF) an AS were assessed by pulse wave analysis with peripheral arterial tonometry, using Endo-PAT 2000, a validated Background and Purpose-Sleep-disordered breathing (SDB) represents a risk factor for cardiovascular morbidity after a cerebral ischemic event (acute ischemic event, ischemic stroke, or transient ischemic attack). In the present study, endothelial function and arterial stiffness were analyzed in patients who experienced a postacute ischemic event with relation to SDB, sleep disruption, and nocturnal oxygenation parameters. Methods-SDB was assessed by full polysomnography in patients with acute ischemic event 3 months after the admission at our stroke unit. Moderate-severe SDB was defined according to the apnea-hypopnea index as apnea-hypopnea index ≥20. Endothelial function and arterial stiffness were assessed by peripheral arterial tonometry using Endo-PAT 2000. Results-Thirty-seven patients were included. The augmentation index was significantly different between patients with apnea-hypopnea index <20 and apnea-hypopnea index ≥20 (

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Carotid Atherosclerosis, Endothelial Disfunction, and Arterial Stiffness in Young and Middle-Aged Men with Coronary Artery Disease

Cited by 9 publications

References 18 publications

Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review

Modifiable risk factors for carotid atherosclerosis: a meta-analysis and systematic review

Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation

Endothelial Dysfunction and Arterial Stiffness in Ischemic Stroke

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