Carotid atherosclerosis in patients with untreated chronic obstructive pulmonary disease

Abstract

In newly diagnosed untreated patients with COPD, the carotid artery IMT and hsCRP were significantly higher than in healthy subjects. These findings suggest that systemic inflammation may play a potential role in preclinical atherosclerosis in COPD.

Atherosclerosis is Associated Comorbidity in Patients with Chronic Obstructive Pulmonary Disease: Ultrasound Assessment of Carotid Intima Media Thickness

“…Additionally, CIMT was found to be significantly higher among our study COPD patients than the controls (0.85±0.18 mm vs. 0.63±0.076 mm, p<0.001). These results coincide with the results of other studies in the literature (4,17,(33)(34)(35)(36)(37)(38)(39).…”

Pulmonary Abnormalities and Carotid Atherosclerosis in Ex-Smokers without Airflow Limitation

“…We also observed signifi cant univariate relationships for 3 He VDP with carotid artery IMT, TPV and VWV, consistent with previous studies that showed relationships between spirometry measurements and carotid IMT (3,4,6,17,55,56), although this is the fi rst report of such relationships in subjects with normal pulmonary function. Similarly, multivariate regression models that controlled for cardiovascular and pulmonary disease risk factors showed that VDP is a signifi cant predictor of carotid artery IMT, VWV and TPV.…”

“…Previous work in COPD patients (3,4,6,7,17,55,56) reported a relationship for IMT with FEV 1 and emphysema measurements, but this was not observed here in ex-smokers without COPD. We were likely underpowered to detect diff erences in IMT between subgroups as these previous studies investigating IMT in COPD and healthy older subjects used sample sizes ranging from 305 to 14,480 subjects.…”

“…In addition, in COPD patients, there is a dose-response relationship for pulmonary structurefunction abnormalities with carotid atherosclerosis (3)(4)(5)(6)(7)(8), coronary artery calcifi cation (9)(10)(11)(12) and vascular dysfunction (13)(14)(15)(16). Although these studies have shown the presence of cardiovascular disease in patients with COPD that cannot be explained by smoking history alone (3,4,(6)(7)(8)17), the mechanisms by which cardiovascular disease may be accelerated in COPD are not clear, nor is our understanding of these relationships in early or milder subclinical stages.…”

Evaluation of carotis intima media thickness in chronic obstructive pulmonary disease patients

“…Eickhoff ve arkadaşları çalışmalarında stabil KOAH hastalarında sigara içen veya içmeyen sağlıklı kişilere göre daha yüksek KİMK'ler ölçmüşlerdir (24). Kim ve arkadaşları da yeni tanı alan ve tedavisine başlanmamış KOAH'lı hastalarda sağlıklı bireylere göre KİMK'yi anlamlı yüksek olarak bulmuşlardır (25). Benzer şekilde, van Gestel ve arkadaşları da damar cerrahisi geçiren hastalarda KO-AH'ın KİMK artışıyla ilişkisini ve artmış KİMK'nin artmış kardiyovasküler mortaliteyle ilişkisini belirtmişler-dir (26).…”