Carotid atherosclerosis is associated with left ventricular diastolic function

Harada, Masahiko; Tabako, Satoshi

doi:10.1007/s12574-016-0296-2

Cited by 9 publications

(5 citation statements)

References 86 publications

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“…Albu et al37 conducted an investigation into 96 postmenopausal women and proposed that aortic PWV was an independent predictor of LVDD (OR 2.15, 95% CI 1.39–3.31, P =0.0006), while carotid plaque score did not show correlation with LVDD after adjustment. However, some investigators reported that the presence of carotid ATS was significantly related to LVDD,38–40 which was in accordance with our finding. Other studies concerning arterial stiffness were not consistent with our results.…”

Section: Discussionsupporting

confidence: 93%

Association of arteriosclerosis and/or atherosclerosis with hypertensive target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai Study

Fan

Zhu

Chen

et al. 2017

CIA

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ObjectiveVascular abnormality includes two forms, arteriosclerosis (ARS) and atherosclerosis (ATS), which coexist in patients with cardiovascular (CV) diseases. However, whether their combination may lead to a worsening status in those patients remains unclear. We therefore aimed to investigate the association of ARS and/or ATS with hypertensive target organ damage (TOD).MethodsFrom June 2014 to August 2015, a total of 1,599 community-dwelling elderly subjects (aged >65 years) from northern Shanghai were recruited. Vascular measurements, such as carotid–femoral pulse wave velocity (cf-PWV), ankle–brachial index (ABI) and carotid plaque, were conducted on each participant, and ARS was defined as cf-PWV >12 m/s, while ATS was defined as participants who have carotid plaque or ABI <0.9. Within the framework of comprehensive CV examinations, CV risk factors were assessed, and asymptomatic TOD was evaluated by measuring participants’ left ventricular mass index (LVMI), peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), urinary albumin–creatinine rate (UACR) and estimated glomerular filtration rate (eGFR).ResultsAlthough LVMI, E/Ea and eGFR were significantly different among subjects with or without ARS and/or ATS (P<0.02), in full adjustment model, only E/Ea showed the independent and significant difference (P=0.023). Moreover, E/Ea was significantly different between participants with ARS or ATS and those without ARS or ATS (P=0.045), while there was no significant difference between participants with ARS and ATS and those without ARS or ATS (P=0.28). Similar results were obtained in the multivariate logistic regression of left ventricular diastolic dysfunction (LVDD). With similar adjustment, LVDD was significantly associated with ATS (P=0.01) but not with ARS (P=0.99).ConclusionIn the community-dwelling elderly Chinese, among hypertensive TOD, LVDD was significantly associated with ATS but not with ARS. The proportion of patients with LVDD was not significantly different despite the presence of both ATS and ARS, when compared to patients with ATS alone.

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Section: Discussionsupporting

confidence: 93%

Association of arteriosclerosis and/or atherosclerosis with hypertensive target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai Study

Fan

Zhu

Chen

et al. 2017

CIA

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“…Regression analysis revealed that EFT in CAH patients correlates with mitral DcT .This is in agreement with the study of Van der Meer which showed that myocardial fat has progressive and harmful effects on LV diastolic function [34]. Diastolic dysfunction has been considered as one of the first echocardiographic abnormalities to appear in patients with atherosclerotic cardiovascular disease with a high rate of release of free fatty acids (FFA) [35], which encounter no physical barrier or fascia before reaching the cardiomyocytes; [36] therefore, the myocardium receives a double dose of FFA from both the EFT and the systemic circulation. EFT is a source of several bioactive molecules that might directly influence the myocardium [37].…”

Section: U N C O R R E C T E D P R O O Fsupporting

confidence: 85%

Epicardial fat thickness in children with classic congenital adrenal hyperplasia

Metwalley¹,

Farghaly²,

Abdelhamid³

2018

Jcrpe

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Objective: Epicardial fat thickness (EFT) is an emerging cardiometabolic risk factor and has been shown to be related to atherosclerosis. EFT has not been studied in the context of CAH. This study aimed to evaluate EFT in children with CAH and its relation to carotid intima media thickness (CA-IMT) and left ventricular functions. Methods: 36 children with classic CAH were compared with 36 healthy controls. All children had confirmed CAH and received steroid substitution therapy. Patients and controls underwent anthropometric evaluation, measurement of fasting lipids, glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-IR), Left ventricular functions and EFT were assessed using conventional echocardiography. Duplex ultrasonography was used to measure CA-IMT. Results: Compared to controls, patients had higher EFT (p=0.001), HOMA-IR(p=0.001), CA-IMT (p=0.01), LVMI (p=0.001) and prolonged mitral deceleration time (DcT) (p=0.01).Abnormalities were marked in uncontrolled children on medical treatment. In multivariate analysis in children with classic CAH , EFT correlated positively with waist circumference (OR =1.9,95%Cl=1.07-1.14.p=001), 17-OHP; nmol/l (OR =1.6; 95% CI = 1.33-2.89, p = 0.05), testosterone , ng/dl(OR =1.7; 95% CI = 1.55-2.13, p = 0.01), LVMI (OR=1.14, 95%Cl=1.08-1.13, p=0.0001) , mitral DcT (OR=2.25;95% CI=1.15-2.05, p=0.01) and CA-IMT (OR=1.6 ;95% CI=1.15-2.05, p=0.01). Conclusions: EFT may be elevated in children with classic CAH particularly those with poor control and is correlated to carotid intima media thickness, left ventricular mass and mitral deceleration time. Measurement of EFT by Echocardiography in CAH children may help to identify those at high risk of developing left ventricular dysfunction and subclinical atherosclerosis.

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“…This is in agreement with the study of Van der Meer (34) which showed that myocardial fat has progressive and harmful effects on LV diastolic function. Diastolic dysfunction has been considered as one of the first echocardiographic abnormalities to appear in patients with atherosclerotic cardiovascular disease with a high rate of release of FFA (35), which encounter no physical barrier or fascia before reaching the cardiomyocytes (36). Therefore, the myocardium receives a double dose of FFA from both the epicardial fat and the systemic circulation.…”

Section: Discussionmentioning

confidence: 99%

Epicardial Fat Thickness in Children with Classic Congenital Adrenal Hyperplasia

Metwalley

Farghaly

Abdelhamid

2019

Jcrpe

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Objective: Epicardial fat thickness (EFT) is an emerging cardio-metabolic risk factor and has been shown to be related to atherosclerosis. EFT has not been studied in the context of CAH. This study aimed to evaluate EFT in children with CAH and its relation to carotid artery intima-media thickness (CA-IMT) and left ventricular (LV) functions. Methods: Thirty-six children with classical CAH were compared with 36 healthy controls. All patients had confirmed CAH and were receiving steroid substitution therapy. Patients and controls underwent anthropometric evaluation, measurement of fasting lipids, glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-IR). LV functions and EFT were assessed using conventional echocardiography. Duplex ultrasonography was used to measure CA-IMT. Results: Compared to controls, patients had greater EFT (p=0.001), CA-IMT (p=0.01), LV mass index (LVMI) (p=0.001) and prolonged mitral deceleration time (DcT) (p=0.01). CAH patients also had significantly worse HOMA-IR (p=0.001) than controls. Abnormalities were worse in uncontrolled CAH on treatment. Multivariate analysis in CAH subjects showed EFT correlated positively with waist circumference odds ratio (OR) [OR=1.9; 95% confidence interval (CI): 1.07-1.14; p=0.01], 17-hydroxyprogesterone [OR=1.6; 95% CI: 1.33-2.89; p=0.05], testosterone concentration (OR=1.7; 95% CI: 1.55-2.13; p=0.01), LVMI (OR=1.14; 95% Cl: 1.08-1.13; p=0.01), mitral DcT (OR=2.25; 95% CI: 1.15-2.05; p=0.01) and CA-IMT (OR=1.6; 95% CI: 1.15-2.05; p=0.01). Conclusion: EFT is elevated in children with classical CAH, particularly in those with poor control, and is correlated with CA-IMT, LV mass and mitral DcT. Measurement of EFT in CAH children may help to identify those at high risk of developing LV dysfunction and subclinical atherosclerosis.

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Carotid atherosclerosis is associated with left ventricular diastolic function

Abstract: The present study demonstrated that decreased early diastolic mitral annular velocity relates to the parameter reflecting carotid atherosclerosis. Therefore, the presence of severe carotid atherosclerosis may affect LV diastolic dysfunction.

Cited by 9 publications

References 86 publications

Association of arteriosclerosis and/or atherosclerosis with hypertensive target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai Study

Association of arteriosclerosis and/or atherosclerosis with hypertensive target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai Study

Epicardial fat thickness in children with classic congenital adrenal hyperplasia

Epicardial Fat Thickness in Children with Classic Congenital Adrenal Hyperplasia

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