Carotid Atherosclerotic Plaque Features in Patients with Acute Ischemic Stroke

Biomarkers of Cardiovascular Disease

“…Атерогенная роль CРБ показана у пациентов с мерцательной аритмией [60], острой эмболией лёгочной артерии [118], коронарным атеросклерозом [85] и ии [141]. У пациентов с изъязвленными бляшками (признак разрыва бляшки) уровни СРБ и ММР9 коррелируют со степенью стеноза и вовлечены в патогенез острого ии [121]. Авторы предлагают использовать ММР9 и СРБ в качестве мишени адьювантной терапии каротидного склероза (КС) на молекулярном уровне.…”

An investigation into the critical role of fibre orientation in the ultimate tensile strength and stiffness of human carotid plaque caps

“…Stroke is known to be one of the leading causes of death and disability in Europe [1,2]. One of the significant contributors to ischemic stroke cases is the development and eventual rupture of atherosclerotic plaques at the carotid bifurcation [3][4][5]. Atherosclerotic plaques are heterogenous tissues that comprise many different structural components such as lipids, calcium, plaque, haemorrhage and fibrous plaque caps [6], all of which contribute to the overall mechanical response of the tissue.…”

Evaluation of lipoprotein‐associated phospholipase A2, serum amyloid A, and fibrinogen as diagnostic biomarkers for patients with acute cerebral infarction

“…Carotid lesions are the main cause of ACI, and atherosclerotic plaque formation is an early pathological feature of carotid lesions in ACI . Atherosclerotic plaques will gradually develop into vascular stenosis and even completely block the cerebral blood flow, leading to an ischemic stroke . Recent researches have confirmed that inflammatory response and various inflammatory factors play an important role in the development of ACI and it has become a research hot spot …”

“…3,4 Atherosclerotic plaques will gradually develop into vascular stenosis and even completely block the cerebral blood flow, leading to an ischemic stroke. 5,6 Recent researches have confirmed that inflammatory response and various inflammatory factors play an important role in the development of ACI and it has become a research hot spot. 7,8 Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor acetylhydrolase, is mainly released from atherosclerotic plaque by macrophages and neutrophils.…”