Carotid body tumor: Ultrastructural observations

Alpert, Lesley; Bochetto, Joseph F.

doi:10.1002/1097-0142(197409)34:3<564::aid-cncr2820340314>3.0.co;2-3

Cited by 22 publications

(3 citation statements)

References 8 publications

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“…For the article, "Curative Potential of Combined Modality Therapy for Advanced Hodgkins Disease" (Oct. 1,1980), the following authors were inadvertently omitted: Michael G. Chen, M.D., David S. Fischer, M.D., and John F. Pezzimenti, M.D.…”

Section: Erratamentioning

confidence: 99%

Malignant carotid body paraganglioma: Light and electron microscopic study of the tumor and its metastases

Robertson

Cooney

1980

Cancer

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A right carotid body paraganglioma (CBP) was removed from a 30-year-old female after finding metastases to cervical lymph nodes. The tumor and its metastases were studied by light and electron microscopy to determine the neoplastic cell type. Light microscopy confirmed the presence of chief cells but was inadequate alone to exclude sustentacular cells. By electron microscopy, only chief cells were found in both the primary and secondary tumors. This is the first report of an ultrastructural study of a metastasis from a malignant CBP. From our observation, we suggest that CBP be defined as a proliferation of chief and sustentacular cells. Electron microscopy is essential to determine the cell types present and thereby help classify the lesion as a tumor or hyperplasia of the carotid body.

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Section: Erratamentioning

confidence: 99%

Malignant carotid body paraganglioma: Light and electron microscopic study of the tumor and its metastases

Robertson

Cooney

1980

Cancer

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“…The histologic features (Richards & Mawdesley-Thomas, 1969;Glenner & Grimley, 1974;Patnaik, Lord & Liu, 1974;Dean & Strafuss, 1975;Patnaik et a/., 1975;Van Nes et al, 1978) and ultrastructural (Grimley & Glenner, 1967;Cheville, 1972;Alpert & Bochetto, 1974;Glenner & Grimley, 1974;Robertson & Cooney, 1980) features of paragangliomas at different sites in man and the dog have been described. Roentgenographic aspects of human head and neck chemodectomas have also been described (Palacios, 1970).…”

Section: Introductionmentioning

confidence: 99%

Canine paraganglioma: a case report

Patnaik

Birchard

1985

J of Small Animal Practice

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An 8‐year‐old castrated Cocker Spaniel with tympanic paraganglioma was presented. The tumour was resected twice with an interval of 120 days. The dog presented with tetraparesis 130 days after the second operation and had radiologic evidence of metastasis to the C5 vertebra. On pathologic examination, metastasis of the tumour was found in the myocardium, lungs, kidney, and C5 vertebra. The tumour, which is being described for the first time in the dog, was highly vascular, and was characterized by various‐sized groups of medium‐sized cells separated by vascular stroma. The neoplastic cells were round or polyhedral with moderately hyperchromatic nuclei, scattered chromatin, indistinct nucleoli, and eosinophilic granular cytoplasm. The metastatic lesions were histologically similar to the primary tumour.

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“…Biochemical, histochemical, and ultrastructural studies have shown that all the paraganglia store catecholamine granules in the chief cells, and that the tumour cells are neoplastic chief cells containing catecho-L. K. Lacquet, A. C. Moulijn, C. M. Jongerius, M. Limburg, and J. B. Rensing lamine granules (Alpert and Bochetto, 1974). The previous distinction between chromaffin and nonchromaffin has therefore become obsolete.…”

mentioning

confidence: 99%

Intrathoracic chemodectoma with multiple localisations.

Lk¹,

Moulijn²,

Jongerius³

et al. 1977

Thorax

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a mediastinal tumour was discovered in an asymptomatic woman with a history of vomiting and an oesophageal anomaly which had not been treated. A tumour of the anterosuperior mediastinum in relation to the aortic arch was extirpated and proved to be a chemodectoma or non-chromaffin paraganglioma.At subsequent follow-ups the mediastinum was never normal and the heart size progressively increased, the oesophageal anomaly remaining unchanged. A small opacity appeared in the left lung in 1974. An operation performed in 1975 revealed an osteochondroma in the lung, pericarditis, and an intrapericardial chemodectoma. The oesophagus was not explored.An intrathoracic chemodectoma is rare. The importance of angiography in its diagnosis is emphasised. Malignant degeneration is seldom observed. Therapy is surgical, the tumour being radioresistant. The possibility to be considered in our patient was either relapse of the tumour with degeneration or multiple localisations of the tumour.

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Carotid body tumor: Ultrastructural observations

Cited by 22 publications

References 8 publications

Malignant carotid body paraganglioma: Light and electron microscopic study of the tumor and its metastases

Malignant carotid body paraganglioma: Light and electron microscopic study of the tumor and its metastases

Canine paraganglioma: a case report

Intrathoracic chemodectoma with multiple localisations.

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