Carotid Intima-media Thickness and its Association with Conventional Risk Factors in Low-income Adults: A Population-based Cross-Sectional Study in China

Liu, Bin; Ni, Jingxian; Shi, Min; Bai, Lingling; Zhan, Chesheng; Lu, Hongzhou; Wu, Yanan; Tu, Jun; Ning, Xianjia; Hao, Junwei; Wang, Jinghua

doi:10.1038/srep41500

Cited by 20 publications

(10 citation statements)

References 36 publications

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“…In comparisons with several Asian samples of populationbased studies, the mean CIMT of our lowest atherosclerosis-risk subgroup (mean age 34.4 years), at 0.66 mm, was higher than the 0.56-0.58 mm noted in a study of Taiwanese older adults with an average of 50 years old (Su et al, 2015), 0.48-0.55 mm noted in a study of Korean adults aged 40-49 years (Youn et al, 2011), and 0.54 mm noted in a Chinese population aged 45-54 years (Liu et al, 2017). These comparisons suggest that CIMT increases before middle age in patients with BD.…”

Section: Patient With Bd Having Greater Cimtcontrasting

confidence: 68%

The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder

Tsai

Shen

Kuo

et al. 2020

Aust N Z J Psychiatry

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Objectives: Patients with bipolar disorder are at high risk of cardiovascular diseases. Among cardiovascular diseases, coronary heart disease and stroke are the leading causes of premature death and both share the pathogenesis of arterial atherosclerosis. Increased carotid intima-media thickness is sensitive for detecting early atherosclerosis and a practical index for predicting cardiovascular diseases. However, few studies investigated carotid intima-media thickness in adults with bipolar disorder. We attempted to determine the factors associated with carotid intima-media thickness in adults with bipolar disorder. Methods: The euthymic out-patients with bipolar I disorder aged over 20 years were recruited to measure the carotid intima-media thickness value through B-mode carotid ultrasound. Those with any psychiatric disorder, acute or life-threatening medical condition were excluded. All clinical information was obtained by reviewing medical records and directly interviewing patients with reliable others. Results: Of the 106 participants with a mean age of 44.5 years, 40.6% ( N = 43) had concurrent cardiovascular/endocrine/metabolic diseases. A multivariate regression indicated that higher assumed daily lithium dosage was significantly associated with a decreased carotid intima-media thickness in the whole sample. In the young subgroup (⩽45 years old, N = 63), higher current daily lithium dosage and lower body mass index were associated with lower carotid intima-media thickness. In those without concurrent cardiovascular/endocrine/metabolic diseases, higher ratio of first-generation antipsychotics exposure in relation to illness chronicity was associated with higher carotid intima-media thickness, after controlling for body mass index or age. Conclusion: Lithium treatment may be associated with less progression in carotid intima-media thickness and the reduced risk for atherosclerosis in adults with bipolar disorder, including those with high cardiovascular disease risk. In addition to age and body mass index, antipsychotics may increase carotid intima-media thickness even in the low cardiovascular disease-risk patients.

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Section: Patient With Bd Having Greater Cimtcontrasting

confidence: 68%

The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder

Tsai

Shen

Kuo

et al. 2020

Aust N Z J Psychiatry

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“…A study from France showed that, after adjusting for confounding variables, an increased CIMT was the only factor significantly and independently associated with high PP, irrespective of the effectiveness of blood pressure control and antihypertensive drug treatments ( 19 ). Our previous study showed a positive association between SBP and CIMT and a negative association between DBP and CIMT ( 16 ). However, the current study showed different results in the univariate analysis.…”

Section: Discussionmentioning

confidence: 91%

“…This cross-sectional survey included 18 villages in rural areas of Tianjin, China, and involved participants from the previously described Tianjin Brain Study (14)(15)(16), conducted between April 2014 and January 2015. In short, about 95% of the total area population (14,251 people) were low-income farmers, with 2014 per capita disposable incomes of <1,600 USD (17).…”

Section: Participants and Study Designmentioning

confidence: 99%

Association Between Pulse Pressure and Carotid Intima-Media Thickness Among Low-Income Adults Aged 45 Years and Older: A Population-Based Cross-Sectional Study in Rural China

Liu

Lin

Guo

et al. 2020

Front. Cardiovasc. Med.

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Worldwide, the stroke burden remains severe, especially for people in low socioeconomic groups. Atherosclerosis is a leading cause of stroke that is attracting increasingly greater attention. Blood pressure, including pulse pressure (PP) and systolic (SBP) and diastolic (DBP) blood pressures, is a traditional risk factor for atherosclerosis; its association with carotid intima-media thickness (CIMT) has also been widely studied. However, published studies have not reported on the relationship between PP and CIMT in low-income adults. Thus, this study investigated the relationship between PP and CIMT in a low-income population, in China. A total of 3,789 people, aged ≥45 years and without histories of stroke or cardiovascular disease, were recruited into this study. B-mode ultrasonography was performed to determine CIMTs. Demographic characteristics, physical examination data, previous medical histories, and laboratory test results were collected for each study participant. Multiple linear regression models were used to analyze the association between CIMT and PP. The mean CIMT was 567.1 μm (males, 583.5 μm; females, 555.7 μm). The SBP, DBP, PP, and mean arterial pressure (MAP) values were all positively correlated with CIMT, in the univariate analysis; PP and MAP showed the strongest correlations. In addition, in three multiple linear regression models, PP was shown to be significantly associated with CIMT; each 1-mm Hg increase in PP resulted in a CIMT increase of ≥0.41 μm (all P < 0.001). Our results demonstrated that, when compared with SBP, DBP, and MAP, PP may be the best predictor of CIMT. Thus, controlling blood pressure, especially PP levels, is vital to decreasing the prevalence of atherosclerosis, especially in this low socioeconomic status population in China.

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“…Education level, monthly income, gestational weeks, and parity were not found to have significant associations with CIMT in our study. A Chinese study, on the other hand, found that higher education is associated with decreased CIMT [ 30 ]. Whatever the education level (>primary) among our participants, a true situation of unavailable electricity in some remote villages exists; therefore, they are to use only solid fuels without other choice.…”

Section: Discussionmentioning

confidence: 99%

Cooking fuels use and carotid intima-media thickness during early pregnancy of women in Myanmar

Min

Taneepanichskul

2020

PLoS ONE

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Background Fuels burned in households for cooking cause indoor air pollution, exposing those who are cooking. Despite the mounting evidence of the effects of fuels use on health, few studies focus on the effect of cooking fuels have on carotid intima-media thickness (CIMT), a surrogate atherosclerosis biomarker in the early stages of pregnancy. This study aimed to examine the association between the use of cooking fuels and CIMT during early trimester of pregnancy among cooking women in Myanmar. Methodology In this cross-sectional study, a part of an ongoing birth cohort analysis, a total of 192 cooking pregnant women over 18 years with gestational weeks less than 18 were recruited from 15 rural health centers in Nay Pyi Taw from September to November 2019. Sociodemographic data, residential data, and fuels use data were collected with semi-structured questionnaires in face-to-face interviews. Anthropometric, hemodynamic, blood lipids, and ultrasound CIMT measurements were performed under standard protocols. Multiple linear regression was modeled to explore associations. Results The study included 70 firewood fuel users, 26 charcoal fuel users, and 96 electricity fuel users. Following adjustments for potential confounding factors, firewood use was significantly associated with the increase of all CIMT analyzed. Importantly, a greater increase of mean CIMT of the right common carotid artery (RCCA; β = 0.033 mm; 95%CI: 0.006, 0.058; P<0.05) had significant association with charcoal use compared to firewood use (β = 0.029 mm; 95%CI: 0.010, 0.049; P<0.05). Conclusions Our findings demonstrate that the indoor use of cooking fuels that cause indoor air pollution, such as firewood and charcoal, is a considerable risk factor for human health and is associated with increased CIMT, wherein charcoal use contributes to more increase of mean CIMT of the RCCA. Measures to prevent health risks related to the use of such fuels should be instituted early on during pregnancy.

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Carotid Intima-media Thickness and its Association with Conventional Risk Factors in Low-income Adults: A Population-based Cross-Sectional Study in China

Cited by 20 publications

References 36 publications

The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder

The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder

Association Between Pulse Pressure and Carotid Intima-Media Thickness Among Low-Income Adults Aged 45 Years and Older: A Population-Based Cross-Sectional Study in Rural China

Cooking fuels use and carotid intima-media thickness during early pregnancy of women in Myanmar

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