Carotid intima media thickness and ankle brachial index are inversely associated in subjects with and without diabetes

Winckler, Karoline; Wiinberg, Niels; Jensen, Andreas Kryger; Thorsteinsson, Birger; Lundby‐Christensen, Louise; Heitmann, Berit Lilienthal; Jensen, Gorm; Tarnow, Lise

doi:10.1080/00365513.2018.1499124

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…32 In addition, The Copenhagen City Heart Study showed that the magnitude of association between these biomarkers was higher in individuals with diabetes, compared with those without the disease. 11 The slope described in the latter group was similar to that observed in men in our results. In contrast, Zhang et al found that the association between IMT and ABI in patients with diabetes did not remain after adjusting for cardiovascular risk factors, but the IMT association with toe-brachial index persisted.…”

Section: Discussionsupporting

confidence: 91%

“…[8][9][10] Most studies have addressed the coexistence atherosclerosis of the lower limbs and carotid artery in selected samples (eg, patients with diabetes, history of stroke, or advanced age). [11][12][13][14] However, these correlations have not been assessed in general population or specifically in individuals with no history of intermittent claudication. In addition, most of the studies did not use automated methods based on machine learning procedures that minimize the reproducibility problem linked to IMT and carotid plaque interpretation.…”

Section: Introductionmentioning

confidence: 99%

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Polyvascular Subclinical Atherosclerosis: Correlation Between Ankle Brachial Index and Carotid Atherosclerosis in a Population-Based Sample

et al. 2022

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We assessed the correlation between the biomarkers of lower limb atherosclerosis (eg, ankle-brachial index [ABI]) and of carotid atherosclerosis (eg, common carotid intima-media thickness (IMT) and presence of atherosclerotic plaque) in a population-based cohort from Girona (Northwest Spain) recruited in 2010. Ankle-brachial index and carotid ultrasound were performed in all participants. Generalized additive multivariable models were used to adjust a regression model of common carotid IMT on ABI. Logistic regression multivariable models were adjusted to assess the probability of carotid plaque in individuals with peripheral artery disease. We included 3307 individuals (54.2% women), mean age 60 years (standard deviation 11). Two patterns of association were observed between subclinical biomarkers of atherosclerosis at the lower limb and carotid artery. Ankle-brachial index and common carotid IMT showed a linear trend in men [beta coefficient (95% confidence interval) =-.068 (−.123; −.012); P = .016]. Women with peripheral artery disease presented with high risk of atherosclerotic plaque at the carotid artery [Odds ratio (95% confidence interval) = 2.61, (1.46; 4.69); P = .001]. Men showed a significant linear association between ABI levels and common carotid IMT values. Women with peripheral artery disease presented with high risk of atherosclerotic plaque at the carotid artery.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Polyvascular Subclinical Atherosclerosis: Correlation Between Ankle Brachial Index and Carotid Atherosclerosis in a Population-Based Sample

et al. 2022

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“…40 More advanced imagistic methods have also confirmed these findings, an angiographic magnetic resonance study reporting a good correlation between the ABI and local atherosclerotic burden. 41 An unusual finding of our study was the different associations of left and right ABI with f-IMT (significant for right ABI vs. f-IMT in the group with low f-IMT vs. left ABI in the group with high f-IMT). We attributed these results to the fact that unilateral stenosis of the peripheral arteries is more common than bilateral lesions, due to the random nature of the atherosclerotic process.…”

Section: Correlations Between F-imt and The Ankle-brachial Indexmentioning

confidence: 47%

Femoral Intima-media Thickness, Risk Factors, and Markers of Inflammation in Cardiovascular Disease

Jeremiás

Makó

Bogdan

et al. 2018

Journal of Interdisciplinary Medicine

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Introduction:The burden of coronary artery disease (CAD) and peripheral vascular pathologies caused by atherosclerosis is constantly increasing. There is continuous research aiming to develop new methods that can evaluate the extent of atherosclerotic disease in different vascular beds, thus estimating global risk. Similar to carotid artery thickness, which is an established marker for increased cardiovascular risk and cerebrovascular disease, femoral intima-media thickness (f-IMT) may have the same role in case of peripheral arterial involvement. The aim of the study was determine whether f-IMT, determined at the level of the superficial femoral artery, is related to traditional risk factors, markers of peripheral vascular atherosclerosis and inflammation. Material and methods: Forty-six patients with known cardiovascular disease were included in the study. Demographical data, cardiovascular history, and risk factors were assessed. We determined metabolic parameters (uric acid, fasting glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides), renal function (creatinine and GFR), and inflammation status for all patients. Each patient underwent ultrasound examination of the superficial femoral artery, by which f-IMT was determined for right and left limbs. Ankle-brachial index was also calculated. Data from the low (f-IMT <0.75 mm) and high (f-IMT >0.75 mm) f-IMT groups were compared and correlation coefficients were determined in each groups for f-IMT in relation to the other parameters. Results: Mean age was 71.08 ± 9.78 years. 86.95% of the patients suffered from hypertension, 56.62% had coronary heart disease, and 21.73% had a history of stroke. More females had history of hypertension and CAD. The most prevalent cardiovascular risk factors were dyslipidemia (68.86%), diabetes (21.73%), and smoking (21.73%). There were significant differences between gender groups for total cholesterol levels (161.36 ± 25.04 mg/dL, in females, p = 0.02), creatinine values (1.04 ± 0.22 mg/dL, 95%CI 0.94-1.14 for males vs. 0.91 ± 0.23 mg/dL, 95%CI 0.81-1.00 for females, p = 0.018), and left f-IMT (0.87 ± 0.18 mm, 95%CI 0.79-0.95 for males vs. 0.75 ± 0.10 mm, 95%CI 0.70-0.79 for females, p = 0.0049). In the group with low f-IMT, a significant, reverse correlation was established between f-IMT, uric acid (r = -0.483, p = 0.042), and right ABI (r = -730, p = 0.0006). In the group with high f-IMT, age (r = 0.408, p = 0.031), fasting glucose (r = 0.407, p = 0.034), total cholesterol (r = 0.429, p = 0.02), HDL-cholesterol (r = -0.56, p = 0.0019), triglycerides (r = 0.45, p = 0.01), hs-CRP (r = 0.45, p = 0.01), and left ABI (r = -0.71, p <0.0001) showed a significant correlation to f-IMT. Conclusions: Increased femoral intima-media thickness is related to age, cardiovascular risk factors, and markers of peripheral arterial disease. Patients with higher f-IMT have a more augmented inflammatory status. Based on these correlations, in patients with cardiovascular disease, f-IMT could become a marker for increased cardi...

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Carotid plague formation is associated with ankle–brachial index in elderly people

Pan

Chen

et al. 2019

Aging Clin Exp Res

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Carotid intima media thickness and ankle brachial index are inversely associated in subjects with and without diabetes

Cited by 7 publications

References 22 publications

Polyvascular Subclinical Atherosclerosis: Correlation Between Ankle Brachial Index and Carotid Atherosclerosis in a Population-Based Sample

Polyvascular Subclinical Atherosclerosis: Correlation Between Ankle Brachial Index and Carotid Atherosclerosis in a Population-Based Sample

Femoral Intima-media Thickness, Risk Factors, and Markers of Inflammation in Cardiovascular Disease

Carotid plague formation is associated with ankle–brachial index in elderly people

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