Carotid Intima-Media Thickness and Serum Endothelial Marker Levels in Obese Children With Metabolic Syndrome

Abstract

To investigate carotid intima-media thickness (IMT) and serum endothelial marker levels in obese Chinese children.

Endothelial and Metabolic Function Interactions in Overweight/Obese Children:

“…D-dimers, fibrinogen, and vWFAg levels did not reach a significant correlation with vascular parameters. These results were in contrast with some previous literature studies, 11,[49][50][51][52] which reported the influence of such parameters on endothelial function and on vascular wall morphological structure. In fact, OrenesPiñero et al 53) pointed out the correlation between BMI and coagulation parameters, observing an increased prothrombotic status in adult subjects suffering from increased body weight.…”

Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

“…Hyper-insulinemia and inheritance of the ApoE-ε4 allele also contribute to cerebrovascular disease and increase risk of AD progression. Insulin resistance and hyperinsulinemia can injure blood vessels and cause intimal thickening, scarring, and leakiness (Huang, Zou et al ;Haudenschild, Van Sickle et al 1981;Hotta, Taguma et al 1996;Kubota, Kubota et al 2003;Kincaid-Smith 2004;Matsumoto, Nakao et al 2005). A recent study demonstrated that chronic ischemic leukoencephalopathy and leukoaraiosis in cerebral autosomal dominant arteriopathy with subacute infarcts and leukoencephalopathy (CADASIL) is associated with white matter microvascular insulin and IGF resistance (Brennan-Krohn, Salloway et al 2010).…”

Association between metabolic syndrome and vascular endothelium dysfunction in children and adolescents

“…We therefore suggest that pathophysiological vascular endothelial changes occur in MS patients as well as obese individuals without MS. Huang et al (2010) also found, using B ultrasound detection of carotid intima-media thickness, that obese children and adolescents without MS had ECD. Therefore, the clinical prevention and control of ECD should not only focus solely on individuals with MS but also on individuals who are obese and do not have MS (Ji, 2007).…”