Carotid plaques, but not common carotid intima–media thickness, are independently associated with aortic stiffness

Zureik, Mahmoud; Temmar, Mohammed; Adamopoulos, Chris; Bureau, J.-M.; Courbon, Dominique; Thomas, Frédérique; Bean, K.; Touboul, Pierre‐Jean; Ducimetière, Pierre; Bénétos, Athanase

doi:10.1097/00004872-200201000-00013

Cited by 136 publications

(103 citation statements)

References 39 publications

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“…In a recent study, we reported that the presence of carotid atherosclerotic plaques detected by B-mode ultrasound but not diffuse intima-media thickening was determinant of aortic arterial stiffness assessed by carotid-femoral pulse-wave velocity (PWV), independent of major known cardiovascular risk factors. 1 These findings obtained from a large study of hypertensive and normotensive subjects corroborate the recent results of the Rotterdam Study, showing that arterial stiffness was related to abdominal aortic and carotid atherosclerotic plaques. 2 The mechanisms linking arterial stiffness to atherosclerosis are not known at present.…”

supporting

confidence: 87%

“…[5][6][7][8] Plaques that appear echolucent on B-mode ultrasound are lipid-rich, whereas echogenic plaques have a higher content of fibrous tissue and calcification. 9 -11 In our above-mentioned study, 1 plaque echogenicity was assessed; in the current article, we report the cross-sectional associations of aortic PWV with carotid echolucent and echogenic plaques in 561 hypertensive and nonhypertensive subjects.…”

mentioning

confidence: 97%

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Echogenic Carotid Plaques Are Associated With Aortic Arterial Stiffness in Subjects With Subclinical Carotid Atherosclerosis

et al. 2003

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Abstract-A better understanding of the interrelationships between the structure and function of the large arteries would lead to optimize cardiovascular disease prevention strategies. In this study, we investigated the relationships of aortic arterial stiffness assessed by carotid-femoral pulse-wave velocity (PWV), with carotid plaque echogenicity assessed by B-mode ultrasound. We analyzed 561 subjects (without coronary heart disease or stroke) who were volunteers for free health examinations (age, 58.3Ϯ10.8 years; 32.6% women). Extracranial carotid plaque echogenicity was graded from 1 (plaque appearing black or almost black) to 4 (plaque appearing white or almost white) according to the Gray-Weale classification. Plaques of grades 1 and 2 were defined as echolucent plaques, and plaques of grades 3 and 4 were defined as echogenic plaques. Key Words: atherosclerosis Ⅲ carotid arteries Ⅲ epidemiology Ⅲ hypertension, arterial Ⅲ ultrasonography S tudying the possible interrelationships between the structure and function of the large arteries would lead to a better understanding of the pathophysiology of vascular diseases, to a better evaluation of stroke and cardiovascular risks, and thus to the development of more adequate disease prevention strategies. In a recent study, we reported that the presence of carotid atherosclerotic plaques detected by B-mode ultrasound but not diffuse intima-media thickening was determinant of aortic arterial stiffness assessed by carotid-femoral pulse-wave velocity (PWV), independent of major known cardiovascular risk factors. 1 These findings obtained from a large study of hypertensive and normotensive subjects corroborate the recent results of the Rotterdam Study, showing that arterial stiffness was related to abdominal aortic and carotid atherosclerotic plaques. 2 The mechanisms linking arterial stiffness to atherosclerosis are not known at present. Atherosclerotic changes in the arterial wall could include smooth muscle cell proliferation, deposition of lipid and accumulation of collagen, elastin, and/or proteoglycans. 3,4 However, it is not known whether plaques with different contents are differentially related to arterial stiffness. Plaque echogenicity as assessed by B-mode ultrasound has been found to reliably predict the content of soft tissue and the amount of calcification. [5][6][7][8] Plaques that appear echolucent on B-mode ultrasound are lipid-rich, whereas echogenic plaques have a higher content of fibrous tissue and calcification. 9 -11 In our above-mentioned study, 1 plaque echogenicity was assessed; in the current article, we report the cross-sectional associations of aortic PWV with carotid echolucent and echogenic plaques in 561 hypertensive and nonhypertensive subjects.

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confidence: 87%

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confidence: 97%

Echogenic Carotid Plaques Are Associated With Aortic Arterial Stiffness in Subjects With Subclinical Carotid Atherosclerosis

et al. 2003

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“…Other studies have found an association between arterial stiffness and atherosclerosis. [8][9][10][11] Several explanations for our findings are possible. The presence of atherosclerosis may lead to arterial stiffening.…”

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confidence: 82%

The association of arterial stiffness and arterial calcification: the Rotterdam Study

et al. 2008

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“…Carotid-femoral PWV was determined automatically with a dedicated, validated device (Complior Colson; Createch Industrie, May, France), as described previously (26). PWV was evaluated by a trained physician with two pressure probes as formerly reported (27).…”

Section: Pwv Evaluationmentioning

confidence: 99%

Vitamin D Affects Survival Independently of Vascular Calcification in Chronic Kidney Disease

Barreto¹,

Barreto²,

Liabeuf³

et al. 2009

Clinical Journal of the American Society of Nephrology

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Results: There was a high prevalence of vitamin D deficiency (42%) and insufficiency (34%). Patients with 25D < 16.7 ng/ml (median) had a significantly lower survival rate than patients with 25D >16.7 ng/ml (mean follow-up, 605 ؎ 217 d; range, 10 to 889; P ‫؍‬ 0.05). Multivariate adjustments (included age, gender, diabetes, arterial pressure, CKD stage, phosphate, albumin, hemoglobin, aortic calcification score and PWV) confirmed 25D level as an independent predictor of all-cause mortality.Conclusions: Vitamin D deficiency and insufficiency were highly prevalent in this CKD cohort. Low 25D levels affected mortality independently of vascular calcification and stiffness, suggesting that 25D may influence survival in CKD patients via additional pathways that need to be further explored.

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Carotid plaques, but not common carotid intima–media thickness, are independently associated with aortic stiffness

Abstract: This study shows that there is a differential association of PWV with CCA-IMT and carotid plaques. The nature of the independent positive association between atherosclerosis and arterial stiffness should be thoroughly investigated.

Cited by 136 publications

References 39 publications

Echogenic Carotid Plaques Are Associated With Aortic Arterial Stiffness in Subjects With Subclinical Carotid Atherosclerosis

Echogenic Carotid Plaques Are Associated With Aortic Arterial Stiffness in Subjects With Subclinical Carotid Atherosclerosis

The association of arterial stiffness and arterial calcification: the Rotterdam Study

Vitamin D Affects Survival Independently of Vascular Calcification in Chronic Kidney Disease

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