Carotid Siphon Calcification Predicts the Symptomatic Progression in Branch Artery Disease With Intracranial Artery Stenosis—Brief Report

Abstract

Background: Arterial calcification in the aortic arch, carotid bifurcation, or siphon on computed tomography was associated with cardiovascular disease. The association between arterial calcification prevalence and progression of branch atheromatous disease (BAD) in intracranial artery atherosclerosis was little investigated. Methods: This study included 310 patients with ischemic stroke from one stroke center. Patients were divided into BAD (110) and non-BAD groups (200). Baseline characteristics, lipids, and arterial calcification were measured. The primary outcome was the prevalence of arterial calcification in BAD progression, and the secondary outcome was the prevalence of calcification in arterial stenosis. The association or correlation among calcification prevalence, lipid markers, and BAD progression was analyzed using logistic regression, receiver operating characteristic curve, and linear regression. Results: Our study found that carotid siphon calcification on computed angiography was more prevalent ( P =0.01) in patients with BAD and also more prevalent ( P <0.001) in intracranial artery stenosis, and its computed tomography values could independently predict the symptomatic progression ( P =0.01). Furthermore, a strong linear correlation between oxidized lipid and calcification density was found (beta=−0.73, P =0.0048) in patients with BAD, a subtype (B-type) of intracranial arterial atherosclerotic disease. Conclusions: We found that carotid siphon calcification was associated with BAD and its computed tomography values could predict the symptomatic progression in patients with intracranial arterial atherosclerotic disease and BAD, indicating the important role of carotid calcification in B-type intracranial arterial atherosclerotic disease. REGISTRATION: URL: http://www.chictr.org.cn ; Unique identifier: ChiCTR1800018315

Dietary Flavonoid Intake and Carotid Calcification in Patients with Ischemic Stroke

“…Second, participants in this study were stroke patients, while those in Spanish study were healthy physical examiners. Previous studies indicated that carotid calcification was associated with atherosclerotic cardiovascular diseases, including ischemic stroke [4]. Third, dairy total flavonoid intake was lower in this study than that in Spanish study (183 ± 234 vs. 546 ± 264 mg/d).…”

“…Intracranial artery calcification was also associated with increased risk of hemorrhage and decreased likelihood of favorable outcome after intravenous thrombolysis in patients with acute non-cardioembolic ischemic stroke [3]. Carotid siphon calcification could predict the symptomatic progression in branch artery disease with intracranial artery stenosis [4].…”

Precranial artery calcification burden: a potential indicator of the clinical outcome of reperfusion in patients with acute large artery occlusion

“…Calcification in the pre-cranial arteries, which include aortic arch calcification (AoAC) and carotid siphon calcification (CaSC), is associated with the burden of systemic calcification. 8 Kim et al. found that calcifications of the internal carotid artery (ICA) can reflect the degree of cerebral atherosclerosis.…”

“…Calcification in the pre-cranial arteries, which include aortic arch calcification (AoAC) and carotid siphon calcification (CaSC), is associated with the burden of systemic calcification. 8 Kim et al found that calcifications of the internal carotid artery (ICA) can reflect the degree of cerebral atherosclerosis. 9 Because the aortic arch to the carotid artery is the only way for intravenous recombinant tissue plasminogen activator (rt-PA) or thrombectomy devices to enter the brain, we hypothesized that assessment of the calcification burden of AoAC and CaSC may be a factor in predicting the outcomes of reperfusion therapy.…”