Carpal tunnel syndrome in postmenopausal women

Kaplan, Yüksel; Kurt, Semiha; Karaer, Hatice

doi:10.1016/j.jns.2008.02.003

Cited by 33 publications

(31 citation statements)

References 32 publications

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“…Retired breeder females were chosen because idiopathic carpal tunnel syndrome, our condition of interest, is most common in post-menopausal women. [19][20][21] The study was approved by our Institutional Animal Care and Use Committee and followed all appropriate animal care and euthanasia guidelines. We utilized an established protocol 14 to induce SSCT fibrosis in six of the rabbits; the other two were used as controls (hereafter referred to as control group).…”

Section: Harvesting and Culturing Of Ssct Fibroblastsmentioning

confidence: 99%

Collagen gel contraction as a measure of fibroblast function in an animal model of subsynovial connective tissue fibrosis

Yang

Thoreson

Gingery

et al. 2015

Journal Orthopaedic Research

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Carpal tunnel syndrome (CTS) is a peripheral neuropathy characterized by non-inflammatory fibrosis of the subsynovial connective tissues (SSCT). A rabbit model of CTS was developed to test the hypothesis that SSCT fibrosis causes the neuropathy. We used a cell-seeded collagen-gel contraction model to characterize the fibrosis in this model in terms of cellular mechanics, specifically to compare the ability of SSCT cells from the rabbit model and normal rabbits to contract the gel, and to assess the effect of transforming growth factor-β1,which is upregulated in CTS, on these cells. SSCT fibrosis was induced in six retired breeder female rabbits which were sacrificed at 6 weeks (N=3) and 12 weeks (n=3). An additional two rabbits served as controls. SSCT was harvested according to a standard protocol. Gels seeded with SSCT cells from rabbits sacrificed at 6 weeks had significantly higher tensile strength (p<0.001) and Young’s modulus (p<0.001) than gels seeded with cells from rabbits sacrificed at 12 weeks or control animals. TGF-β1 significantly increased the decay time constant (p<0.001), tensile strength (p<0.001) and Young’s modulus (p<0.001) regardless of the cell source. This model may be useful in screening therapeutic agents that may block SSCT fibrosis, identifying possible candidates for CTS treatment.

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Section: Harvesting and Culturing Of Ssct Fibroblastsmentioning

confidence: 99%

Collagen gel contraction as a measure of fibroblast function in an animal model of subsynovial connective tissue fibrosis

Yang

Thoreson

Gingery

et al. 2015

Journal Orthopaedic Research

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“…The association between parity and CTS is controversial. In a study by Kaplan et al12, the mean parity was significantly higher in postmenopausal women with CTS while Ferry et al13 found a weak, but statistically significant, overall link between parity and CTS. In contrast to these studies and in the same line with our results, Dieck and Kelsey14 demonstrated that the parity was not associated with an increased or decreased frequency of the CTS.…”

Section: Discussionmentioning

confidence: 95%

“…Although a study on 156 CTS cases and 473 controls could not show a clear relationship between age at menopause and CTS 7 Kaplan et al12 found significantly lower age at menopause in the postmenopausal women with CTS. In contrast, in the survey by Dieck and Kelsey14, postmenopausal women with CTS had a somewhat later age at natural menopause.…”

Section: Discussionmentioning

confidence: 96%

Correlation between Female Sex Hormones and Electrodiagnostic Parameters and Clinical Function in Post-menopausal Women with Idiopathic Carpal Tunnel Syndrome

et al. 2016

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ObjectivesTo investigate the role of sex-hormonal changes in idiopathic carpal tunnel syndrome (CTS) among post-menopausal women through measuring estrogen receptor (ER) expression in their transverse carpal ligament (TCL) and serum estrogen level, as well as determine the correlation between these factors and electrodiagnostic parameters and Boston score.MethodsBiopsy samples of TCL were collected from 12 postmenopausal women who had undergone surgery for severe idiopathic CTS; control specimens were collected from 10 postmenopausal women without CTS who had undergone surgery for the other hand pathologies. To determine the distributions of ER in TCL, histological and immunohistochemical examinations were performed. Serum estrogen level was also measured. Electrodiagnosis and Boston questionnaire were used for CTS severity and determination of the patients' function.ResultsER expression in TCL and serum estrogen level were not significantly different in the case group compared to the control group (P = 0.79 and P = 0.88, respectively). Also, there was no correlation between ER expression or serum estrogen level and electrodiagnostic parameters or Boston score.ConclusionsSex hormones cannot still be considered as the etiology of idiopathic CTS in postmenopausal women. The role of other factors such as wrist ratio and narrower outlet in females compared to the males should be considered along with hormonal changes.

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“…In addition to the vibration, there are other factors that increase the likelihood of PNI, such as vitamin deficiencies, systemic diseases, metabolic and endocrine disorders, and hormonal imbalances like estrogen deficiency 20,26,27 . As a result of the menopause, the prevalence of carpal tunnel syndrome is owned by four times greater in women than in men [26][27][28] . This hormonal influence on the nervous tissue can occur due to the protective effect that is discussed from observations of the sex-differences in the responses to CNS injury.…”

Section: Discussionmentioning

confidence: 99%

Morphological and nociceptive effects of mechanical vibration on the sciatic nerve of oophorectomized Wistar rats

Kakihata

Peretti

Wutzke

et al. 2019

Motriz: rev. educ. fis.

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Aim: To evaluate the effects of whole-body vibration in the sciatic nerve of oophorectomized Wistar rats, on nociceptive and morphological parameters, such as fiber, axon, and myelin sheath diameters, G ratio, number of nerve fiber and nuclei of Schwann cells, and percentage of connective tissue. Method: Sixty-four rats were used in the groups sham-operate and oophorectomy (n = 32/group); after surgical procedures, each group was subdivided into four: euthanized in the 12 th week, untreated and treated for four weeks; and euthanized in the 16 th week, untreated and treated for eight weeks. The treatment with vibration was performed with a 60 Hz frequencies, for 10 minutes, three days a week, with duration of 4 or 8 weeks. Nociception was evaluated later, in the right paw, by means of a digital analgesimeter, prior to surgery, at the beginning and at the end of the protocol. After the trial period, the sciatic nerve was dissected for examination of the general morphology of the tissue and morphometric analysis; later, the animals were euthanized. Results: Regarding nociception and the morphometry of the sciatic nerve, independent of oophorectomy and treatment time, there was no statistically significant difference within and between groups. Also, the general morphology of the tissue in all groups had characteristics that were preserved. Conclusion: The mechanical vibration did not alter the nociceptive threshold and the morphological aspects of nerve fibers in oophorectomized Wistar rats.

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Carpal tunnel syndrome in postmenopausal women

Cited by 33 publications

References 32 publications

Collagen gel contraction as a measure of fibroblast function in an animal model of subsynovial connective tissue fibrosis

Collagen gel contraction as a measure of fibroblast function in an animal model of subsynovial connective tissue fibrosis

Correlation between Female Sex Hormones and Electrodiagnostic Parameters and Clinical Function in Post-menopausal Women with Idiopathic Carpal Tunnel Syndrome

Morphological and nociceptive effects of mechanical vibration on the sciatic nerve of oophorectomized Wistar rats

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