Carpentier-Edwards aortic pericardial bioprosthetic valve as a valid control in preclinical in vivo ovine studies

Harvey, Laura; Bianco, Richard W.; Lahti, Matthew T.; Carney, John P.; Zhang, Lindsey; Robinson, Nicholas A.

doi:10.1016/j.ejphar.2015.03.033

Cited by 8 publications

(13 citation statements)

References 15 publications

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“…80 kg body weight) swine. Such animal models are often used during the initial steps of the development of new materials intended for use in human medicine (1,3,9,10,16,19). The DanBred breed was chosen because of its reported resistance to stress and infection (source: DanBred International.…”

Section: Resultsmentioning

confidence: 99%

“…Large animals, such as swine or sheep, are often used during the initial evaluation of the biocompatibility of new materials developed for use in human medicineparticularly in vascular and cardiac surgery (1, 3, 8-10, 16, 17, 19). Without such studies, the development and clinical use of artificial and biological heart valve prostheses would not be possible, preventing the opportunity to successfully treat hundreds of thousands of patients with these devices (1,9). The search for new materials suitable for use in reconstructive, vascular and cardiac surgery is continuing.…”

Section: Praca Oryginalna Original Papermentioning

confidence: 99%

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Challenges in using anesthesia for open chest and aorta surgery in swine

Kowalik¹,

Siondalski²,

Kołaczkowska³

et al. 2020

Medycyna Weterynaryjna

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Anesthesia for aorta surgery in pigs remains challenging due to the requirements for mechanical ventilation and the need for maintaining adequate homeostasis. We report an improved anesthesia protocol in an in vivo animal model to test a novel bacterial nanocellulose (BNC) within the ‘Kardio-BNC’ trial. Forty-four 6-month-old DanBred pigs comprising 6 males and 38 females (body weight ca. 82 kg) underwent implantation of pericardium reconstructive patches (n = 8), thoracic aorta prostheses (n = 15), or both procedures (n = 17) to test the biocompatibility of the novel BNC. The primary endpoint was 90-day survival, and the secondary outcome was death for any reason before reaching the study endpoint. Univariate analysis and linear regression were used to identify variables associated with premature mortality. Of the 44 pigs that underwent surgery, 10 (23%) were lost intra-operatively because of arrhythmia (n = 1), anesthesiological causes (n = 4), or surgical complications (n = 5). Modifications to tracheal intubation, tube fixation, temperature maintenance, and vascular catheterization increased the survival rate to 91% in the last quartile of the animals that underwent surgery. Of the 34 animals that survived surgery, n = 10 (29%) were lost post-operatively because of hematoma (n = 2), pneumothorax (n = 1), or infection (n = 7). Infection was associated with the type of surgery (highest prevalence in animals undergoing the combined procedure; p = 0.02), azaperone dose (p = 0.03), intra-operative heart rate variability (p = 0.03), and crystalloid transfusion (p = 0.04). The anesthesiological strategies and modifications to surgery described here allowed safe open chest and aorta surgery in up to 91% of the procedures performed

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Section: Resultsmentioning

confidence: 99%

Section: Praca Oryginalna Original Papermentioning

confidence: 99%

Challenges in using anesthesia for open chest and aorta surgery in swine

Kowalik¹,

Siondalski²,

Kołaczkowska³

et al. 2020

Medycyna Weterynaryjna

View full text Add to dashboard Cite

show abstract

“…Surgery was performed in the right decubitus position with left 3rd intercostal space thoracotomy to expose the heart and the aorta. The animals were anticoagulated and placed on CPB using standard techniques [13][14][15][16]. The animal was cooled to 28˚C, and the aorta was cross clamped proximal to the junction of the brachiocephalic trunk.…”

Section: Modified Aortic Annuloplasty (Maa)mentioning

confidence: 99%

New Model for the Assessment of Transcatheter Aortic Valve Replacement Devices in Sheep

Carney

Faustich

Lahti

et al. 2020

Journal of Investigative Surgery

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“…In addition, to bring this newly designed bovine pericardial valve into patients, large animal model study against the current standards of treatment should be launched. Based on previous literatures, the mitral position in juvenile ovine model has been testified appropriate for experimental artificial heart valve implantment for both aortic and mitral bioprosthetic valves (3,4). Five months follow-up has been designed based on the ISO 5840:2005 and it is long enough to cause certain calcification in the bioprosthetic valves in juvenile sheep (5-7).…”

Section: Introductionmentioning

confidence: 99%

“…Five months follow-up has been designed based on the ISO 5840:2005 and it is long enough to cause certain calcification in the bioprosthetic valves in juvenile sheep (5-7). Thus we evaluated the safety and efficacy of the SCBC valve compared with CE Perimount TM valve in juvenile sheep model (3,8,9).…”

Section: Introductionmentioning

confidence: 99%