Carrageenan Based Bionanocomposites as Drug Delivery Tool with Special Emphasis on the Influence of Ferromagnetic Nanoparticles

Khan, Abida Kalsoom; Saba, Ain Us; Nawazish, Shamyla; Akhtar, Fahad; Rashid, Rehana; Mir, Sadullah; Nasir, Bushra; Iqbal, Furqan Muhammad; Afzal, Samina; Pervaiz, Fahad; Murtaza, Ghulam

doi:10.1155/2017/8158315

Cited by 61 publications

(21 citation statements)

References 101 publications

(121 reference statements)

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“…For example, the use of pH-responsive biopolymers such as chitosan led to carriers that provide enhanced drug release in the tumor acidic microenvironment (due to anaerobic glucose metabolism) and in acidic intracellular organelles (such as endosomes and lysosomes), over release in blood [3,[17][18][19][20][21]. Magnetic nanocarriers, either individual or as components of hybrid nanomaterials [16,[22][23][24][25][26], have also been recognized as drug release vectors having with several advantages [10,27]. Indeed, magnetic nanocarriers can be guided towards target tissues under a magnetic gradient and eventually be used as contrast agents for magnetic resonance imaging (MRI), thus allowing for simultaneous cancer treatment and monitoring [24,26].…”

Section: Characterization Of the Magnetic Nanocarriersmentioning

confidence: 99%

“…Examples of systems reported in the literature include pH-responsive hydrogels for intestinal drug delivery [46], hybrid calcium-biopolymer microparticles for DOX delivery [47,48] and k-carrageenan-coated γ-Fe 2 O 3 nanoparticles with chemotherapeutic potential [49]. While there has been research on the combination of magnetic particles with carrageenan for drug delivery [27], there are no reported works combining such systems with DOX.…”

Section: Characterization Of the Magnetic Nanocarriersmentioning

confidence: 99%

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Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

et al. 2020

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Doxorubicin is one of the most widely used anti-cancer drugs, but side effects and selectivity problems create a demand for alternative drug delivery systems. Herein we describe a hybrid magnetic nanomaterial as a pH-dependent doxorubicin release carrier. This nanocarrier comprises magnetic iron oxide cores with a diameter of 10 nm, enveloped in a hybrid material made of siliceous shells and ĸ-carrageenan. The hybrid shells possess high drug loading capacity and a favorable drug release profile, while the iron oxide cores allows easy manipulation via an external magnetic field. The pH responsiveness was assessed in phosphate buffers at pH levels equivalent to those of blood (pH 7.4) and tumor microenvironment (pH 4.2 and 5). The nanoparticles have a loading capacity of up to 12.3 wt.% and a release profile of 80% in 5 h at acidic pH versus 25% at blood pH. In vitro drug delivery tests on human breast cancer and non-cancer cellular cultures have shown that, compared to the free drug, the loaded nanocarriers have comparable antiproliferative effect but a less intense cytotoxic effect, especially in the non-cancer cell line. The results show a clear potential for these new hybrid nanomaterials as alternative drug carriers for doxorubicin.

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Section: Characterization Of the Magnetic Nanocarriersmentioning

confidence: 99%

Section: Characterization Of the Magnetic Nanocarriersmentioning

confidence: 99%

Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

et al. 2020

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“…The use of carrageenan in the pharmaceutical field is increased due to its biocompatibility and consolidation behavior. It will help to improve the drug formulation properties including prolonged drug release [ 50 ]. Surfactin is a biosurfactant that has large application in the clinical field.…”

Section: Discussionmentioning

confidence: 99%

In-Vitro Antibacterial and Anti-Inflammatory Effects of Surfactin-Loaded Nanoparticles for Periodontitis Treatment

et al. 2021

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Periodontitis is an inflammatory disease associated with biofilm formation and gingival recession. The practice of nanotechnology in the clinical field is increased overtime due to its potential advantages in drug delivery applications. Nanoparticles can deliver drugs into the targeted area with high efficiency and cause less damages to the tissues. In this study, we investigated the antibacterial and anti-inflammatory properties of surfactin-loaded κ-carrageenan oligosaccharides linked cellulose nanofibers (CO-CNF) nanoparticles. Three types of surfactin-loaded nanoparticles were prepared based on the increasing concentration of surfactin such as 50SNPs (50 mg surfactin-loaded CO-CNF nanoparticles), 100SNPs (100 mg surfactin-loaded CO-CNF nanoparticles), and 200SNPs (200 mg surfactin-loaded CO-CNF nanoparticles). The results showed that the nanoparticles inhibited the growth of Fusobacterium nucleatum and Pseudomonas aeruginosa. The reduction in biofilm formation and metabolic activity of the bacteria were confirmed by crystal violet and MTT assay, respectively. Besides, an increase in oxidative stress was also observed in bacteria. Furthermore, anti-inflammatory effects of surfactin-loaded CO-CNF nanoparticles was observed in lipopolysaccharide (LPS)-stimulated human gingival fibroblast (HGF) cells. A decrease in the production of reactive oxygen species (ROS), transcription factor, and cytokines were observed in the presence of nanoparticles. Collectively, these observations supported the use of surfactin-loaded CO-CNF as a potential candidate for periodontitis management.

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“…Because of their organized, ordered and stable networks as well as wide water-pockets, carrageenans are used as vehicles to deliver drug cargoes [ 381 ]. Carrageenan-based formulations used as drug delivery systems include hydrogels, hydrogel beads, microspheres and microparticles [ [382] , [383] , [384] ]. Carrageenan is an ideal excipient for controlled release in drug delivery systems.…”

Section: Medical Applicationsmentioning

confidence: 99%

Biomaterials from the sea: Future building blocks for biomedical applications

Wan

Qin

Chen

et al. 2021

Bioactive Materials

105

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Marine resources have tremendous potential for developing high-value biomaterials. The last decade has seen an increasing number of biomaterials that originate from marine organisms. This field is rapidly evolving. Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials. The latter are represented by chitin and chitosan, marine-derived collagen, and composites of different organisms of marine origin. The diversity of marine natural products, their properties and applications are discussed thoroughly in the present review. These materials are easily available and possess excellent biocompatibility, biodegradability and potent bioactive characteristics. Important applications of marine biomaterials include medical applications, antimicrobial agents, drug delivery agents, anticoagulants, rehabilitation of diseases such as cardiovascular diseases, bone diseases and diabetes, as well as comestible, cosmetic and industrial applications.

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Carrageenan Based Bionanocomposites as Drug Delivery Tool with Special Emphasis on the Influence of Ferromagnetic Nanoparticles

Cited by 61 publications

References 101 publications

Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

In-Vitro Antibacterial and Anti-Inflammatory Effects of Surfactin-Loaded Nanoparticles for Periodontitis Treatment

Biomaterials from the sea: Future building blocks for biomedical applications

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