Carriage of Enterobacteria Producing Extended-Spectrum β-Lactamases and Composition of the Gut Microbiota in an Amerindian Community

Gosalbes, María José; Angebault, Cécile; Woerther, Paul‐Louis; Ruppé, Étienne; Ferrús, María Loreto; Latorre, Amparo; Andremont, Antoine; Moya, Andrés

doi:10.1128/aac.01528-15

Cited by 42 publications

(33 citation statements)

References 37 publications

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“…Some factors seem to be associated with the duration of intestinal colonization such as bacterial species [94][95][96], microbiota composition [41,[97][98][99], previous non-antibiotic drugs [100] and previous antibiotic therapy [89,[101][102][103]].…”

Section: Digestive Colonization By Multidrug-resistant Bacteria and Gmentioning

confidence: 99%

Gut Microbiota, Antibiotic Therapy and Antimicrobial Resistance: A Narrative Review

2020

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Antimicrobial resistance is a major concern. Epidemiological studies have demonstrated direct relationships between antibiotic consumption and emergence/dissemination of resistant strains. Within the last decade, authors confounded spectrum activity and ecological effects and did not take into account several other factors playing important roles, such as impact on anaerobic flora, biliary elimination and sub-inhibitory concentration. The ecological impact of antibiotics on the gut microbiota by direct or indirect mechanisms reflects the breaking of the resistance barrier to colonization. To limit the impact of antibiotic therapy on gut microbiota, consideration of the spectrum of activity and route of elimination must be integrated into the decision. Various strategies to prevent (antimicrobial stewardship, action on residual antibiotics at colonic level) or cure dysbiosis (prebiotic, probiotic and fecal microbiota transplantation) have been introduced or are currently being developed.

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Section: Digestive Colonization By Multidrug-resistant Bacteria and Gmentioning

confidence: 99%

Gut Microbiota, Antibiotic Therapy and Antimicrobial Resistance: A Narrative Review

2020

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“…In particular, we analyzed the pre-and post-travel composition of metabolically active microbiota which has been previously shown to provide a better differentiation between ESBL-carriers and non-carriers. 17…”

Section: Introductionmentioning

confidence: 99%

The intestinal microbiota predisposes to traveler’s diarrhea and to the carriage of multidrug-resistant Enterobacteriaceae after traveling to tropical regions

et al. 2019

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The risk of acquisition of multidrug-resistant Enterobacteriaceae (MRE) and of occurrence of diarrhea is high when traveling to tropical regions. The relationships between these phenomena and the composition of human gut microbiota have not yet been assessed. Here, we investigated the dynamics of changes of metabolically active microbiota by sequencing total RNA from fecal samples taken before and after travel to tropical regions. We included 43 subjects who could provide fecal samples before and after a travel to tropical regions. When found positive by culturing for any MRE after travel, the subjects sent an additional sample 1 month later. In all, 104 fecal samples were considered (43 before travel, 43 at return, 18 one month after travel). We extracted the whole RNA, performed retrotranscription and sequenced the cDNA (MiSeq 2x300bp). The reads were mapped to the reference operational taxonomic units (OTUs) and species/strains using the 16S Greengenes and 23S SILVA databases. We found that the occurrence of diarrhea during the travel was associated with a higher relative abundance of Prevotella copri before departure and after return. The composition of microbiota, before travel as well as at return, was not correlated with the acquisition of MRE. However, the clearance of MRE one month after return was linked to a specific pattern of bacterial species that was also found before and after return. In conclusion, we found specific OTUs associated to a higher risk of diarrhea during a stay in tropical regions and to a faster clearance of MRE after their acquisition.

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“…was associated with lack of MDRO acquisition, consistent with a protective role. In a study that addressed the role of certain changes in the composition of the microbiota as a risk factor of ESBL-PE colonization, Gosalbes and colleagues highlighted a similar richness of taxa but a significant difference in species of four genera between carriers and non-carriers 40 .…”

Section: The Role Of Microbiota In the Acquisition Of Multidrug-resismentioning

confidence: 99%

The potential role of microbiota for controlling the spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in neonatal population

et al. 2017

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The spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in the hospital and also the community is worrisome. Neonates particularly are exposed to the risk of ESBL-PE acquisition and, owing to the immaturity of their immune system, to a higher secondary risk of ESBL-PE-related infection. Reducing the risk of acquisition in the hospital is usually based on a bundle of measures, including screening policies at admission, improving hand hygiene compliance, and decreasing antibiotic consumption. However, recent scientific data suggest new prevention opportunities based on microbiota modifications.

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Carriage of Enterobacteria Producing Extended-Spectrum β-Lactamases and Composition of the Gut Microbiota in an Amerindian Community

Cited by 42 publications

References 37 publications

Gut Microbiota, Antibiotic Therapy and Antimicrobial Resistance: A Narrative Review

Gut Microbiota, Antibiotic Therapy and Antimicrobial Resistance: A Narrative Review

The intestinal microbiota predisposes to traveler’s diarrhea and to the carriage of multidrug-resistant Enterobacteriaceae after traveling to tropical regions

The potential role of microbiota for controlling the spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in neonatal population

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