Carriage of group B Streptococcus in pregnant women and newborns: a 2-year study at Perugia General Hospital

Sensini, Alessandra; Tissi, Luciana; Verducci, Nadia; Orofino, Maristella; Hunolstein, Christina von; Brunelli, B; Malà, Gian Luca; Perocchi, F; Brunelli, Roberta de Matos; Lauro, Vincenzo Di; Ferrarese, R; Gilardi, G

doi:10.1111/j.1469-0691.1997.tb00621.x

Cited by 19 publications

(24 citation statements)

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“…3,29,30 Our investigation shows that the III, V and Ia serotypes were the most prevalent and the most resistant to antibiotics, in agreement with the results of other authors. 29,31 These serotypes are more frequently responsible for neonatal diseases and the strains belonging to the V serotype, in particular, seem to be the most invasive and MLS-resistant.…”

Section: Discussionsupporting

confidence: 95%

“…2,5 An Italian report of 1997 indicates a vertical transmission rate from colonized mothers to newborns of 41.5%. 3 The outcome of neonatal infection may be bacterial sepsis, pneumonia and meningitis, that in Europe and United States have a mortality rate of 4e6%. 2 In 1996 the U.S. Center for Disease Control and Prevention recommended a screening-based strategy to prevent the perinatal transmission of streptococcal disease from pregnant women to newborns during delivery.…”

Section: Introductionmentioning

confidence: 99%

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Streptococcus agalactiae in pregnant women: Phenotypic and genotypic characters

Savoia

Gottimer

Crocilla³

et al. 2008

Journal of Infection

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Section: Discussionsupporting

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Streptococcus agalactiae in pregnant women: Phenotypic and genotypic characters

Savoia

Gottimer

Crocilla³

et al. 2008

Journal of Infection

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“…Vaginal and rectal swabs in our population of pregnant women were positive for GBS in 7.98% of cases; this value is slightly lower than the national average, which is about 10-20% [19]: in North Eastern Italy it is reported as 17.9% [20], in Perugia 11.3% [21], in Friuli Venezia Giulia 19.7% [22]. …”

Section: Discussionmentioning

confidence: 91%

Epidemiology of Toxoplasma and CMV serology and of GBS colonization in pregnancy and neonatal outcome in a Sicilian population

et al. 2014

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BackgroundAim of our study is to analyze the immunological status in pregnancy for two main TORCH agents, Toxoplasma and Cytomegalovirus (CMV), and the results of group B streptococcus (GBS) screening, assessing the risk for congenital infection in a population from Palermo, Italy.MethodsWe retrospectively analyzed the medical records of all inborn live newborns who were born in our division during 2012, gathering information about the mother, the pregnancy and neonatal hospitalization at birth. Whenever data were available, we categorized the serologic status of the mothers for Toxoplasma and CMV. We also considered the results of rectal and vaginal swabs for GBS. We compared the results in Italian and immigrant mothers. The neonatal outcome was evaluated in all cases at risk.ResultsPrevalence of anti-Toxo IgG antibodies was 17.97%, and was significantly higher in immigrant women (30% vs 16.4% in Italian women; p = 0.0008). Prevalence of anti-CMV IgG antibodies was 65.87%. Again, it was significantly higher in immigrant women (91.4% vs 62.5%, p = 3.31e-08). We compared those data with a previous study performed in our hospital in 2005–2006, and found that the prevalence of anti-Toxoplasma and anti-CMV antibodies in our population has remained stable, both in the immigrant and in the local population. Seroconversion rates and neonatal infections were rare: no seroconversions were observed for Toxoplasma, 4 seroconversions for CMV. One neonatal Toxoplasma infection and two neonatal CMV infections were documented. In some cases with dubious patterns or probable persistence of IgM, we performed additional tests and follow-up. Vaginal and rectal swabs were positive for GBS in 7.98% of cases, with no significant difference between the Italian and the immigrant population. No GBS neonatal sepsis was documented.ConclusionsThe prevalence of Toxoplasma IgG antibodies in pregnant women was low in our population, if compared with European countries and with other parts of Italy, and is significantly higher in immigrant women. The prevalence of CMV IgG antibodies was intermediate if compared to other countries, and it was higher in immigrant women. GBS positivity was low, and comparable in Italian and immigrant mothers. Neonatal infection was rare for all these agents.

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“…Invasive GBS infection in newborns during the first week of life, known as early-onset GBS disease, is mainly caused by vertical transmission of GBS from colonized mothers to their infants during labor or delivery. Approximately 10z-30z of pregnant women are colonized with GBS, and the incidence of early-onset GBS disease is 0.3-2 per 1,000 live births (1)(2)(3)(4). Intrapartum antibiotic prophylaxis is effective in reducing early-onset GBS disease (5).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Group B Streptococcus Isolated from Women in Saitama City, Japan

et al. 2012

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SUMMARY: Streptococcus agalactiae (group B streptococcus; GBS) is a common cause of neonatal sepsis and meningitis. Intrapartum antibiotic prophylaxis is effective in reducing neonatal GBS disease. Penicillin is recommended for intrapartum antibiotic prophylaxis; however, other antibiotics are administered to pregnant women with penicillin allergy. Serotyping and antibiotic susceptibility testing were performed on 376 GBS isolates collected from vaginal swabs in Saitama City. Of the 376 isolates, 328 (87.2z) were obtained from obstetrics and gynecology clinics. Although approximately 80z of the isolates (299/376) were from women of reproductive age (age, 15-49 years), no definite information on their pregnancy status was obtained. The most frequent serotype was V (19.1z) followed by Ib (18.6z), III (16.2z), VI (14.9z), and Ia (14.6z). None of the isolates were resistant to penicillins and cephalosporins. Isolates that were resistant to erythromycin (12.8z), clindamycin (9.0z), ofloxacin (19.4z), levofloxacin (18.4z), and tetracycline (46.5z) were detected. There was a high prevalence of resistance to erythromycin (39.3z) and clindamycin (27.9z) in serotype III. In addition, almost all serotype Ib isolates were resistant to ofloxacin and levofloxacin (both, 91.4z). Pulsed-field gel electrophoresis analysis on certain GBS isolates (serotype Ib, III, and V) indicated that there was genetic diversity among the resistant isolates obtained from a limited area of Japan. In conclusion, present intrapartum antibiotic prophylaxis with penicillins would be effective in Japan; however, performing susceptibility testing before administering other antibiotics is important in order to ensure activity against the relevant isolate.

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Carriage of group B Streptococcus in pregnant women and newborns: a 2-year study at Perugia General Hospital

Cited by 19 publications

References 24 publications

Streptococcus agalactiae in pregnant women: Phenotypic and genotypic characters

Streptococcus agalactiae in pregnant women: Phenotypic and genotypic characters

Epidemiology of Toxoplasma and CMV serology and of GBS colonization in pregnancy and neonatal outcome in a Sicilian population

Characterization of Group B Streptococcus Isolated from Women in Saitama City, Japan

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