2023
DOI: 10.3390/biomedicines11061747
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Carrier-Free Inhalable Dry Microparticles of Celecoxib: Use of the Electrospraying Technique

Azin Jahangiri,
Ali Nokhodchi,
Kofi Asare-Addo
et al.

Abstract: Upregulation of cyclooxygenase (COX-2) plays an important role in lung cancer pathogenesis. Celecoxib (CLX), a selective COX-2 inhibitor, may have beneficial effects in COVID-19-induced inflammatory storms. The current study aimed to develop carrier-free inhalable CLX microparticles by electrospraying as a dry powder formulation for inhalation (DPI). CLX microparticles were prepared through an electrospraying method using a suitable solvent mixture at two different drug concentrations. The obtained powders wer… Show more

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“…In their work on celecoxib, Jahangiri et al optimized the composition of the solvent mixture and drug concentration to obtain an MMAD of 2.82 µm, which is significantly lower than the untreated drug (4.73 µm). Furthermore, electrospraying was reported not to affect the drug’s crystallinity, functionality, or bioactivity [ 129 ].…”
Section: Approaches For Particle Engineeringmentioning
confidence: 99%
“…In their work on celecoxib, Jahangiri et al optimized the composition of the solvent mixture and drug concentration to obtain an MMAD of 2.82 µm, which is significantly lower than the untreated drug (4.73 µm). Furthermore, electrospraying was reported not to affect the drug’s crystallinity, functionality, or bioactivity [ 129 ].…”
Section: Approaches For Particle Engineeringmentioning
confidence: 99%