Carrier-mediated solvent bar microextraction coupled with HPLC-DAD for the quantitative analysis of the hydrophilic antihypertensive peptide VLPVPR in human plasma

Abstract

Aliquat-336, an anion carrier, facilitates the extraction of hydrophilic VLPVPR peptide by Solvent-Bar-Micro-Extraction, achieving sensitive peptide analysis in biological samples.

Simultaneous determination of furosemide and carbamazepine in biological matrices by solvent bar microextraction combined with high‐performance liquid chromatography–diode array detector and central composite design

“…The earlier coefficients indicate that extraction time has an equal effect on drugs’ EE%. Fundamentally, drug extraction is based on partitioning thermodynamics between the donor (sample solution) and acceptor phases as the extracted amount of analyte is determined by equilibrium time (Wang et al, 2017). Thus, a higher EE% is expected at a longer extraction time until reaching equilibrium.…”

A new approach for determination of urinary 8-hydroxy-2′-deoxyguanosine in cancer patients using reinforced solid/liquid phase microextraction combined with HPLC-DAD

“…Essentially, the process of the MWCNTs-HF-SLPME is based on partitioning thermodynamics between the donor (sample solution) and acceptor phase as the amount of the analyte extracted is determined by equilibrium time [40], therefore, the EE% is expected to increase with extraction time until reaching of equilibrium. To determine the required time for the establishment of the equilibrium condition in the MWCNTs-HF-SLPME method, the influence of extraction time was investigated by varying the time intervals from 10 to 60 min with 10 ng mL À1 as the concentration of selected analytes and for other conditions (see section effect of the number of MWCNTs-HF-SLPME devices).…”

Emerging Extraction Strategies in Analytical Chemistry

“…Recent examples on new applications are SBME of ultratrace levels of silver and cadmium from marine waters and extraction of ephedrine from human urine . Implementation of more advanced extraction chemistries involve the use of ionic liquids and the use of carrier-mediated extraction . In the latter paper, methyl trioctyl ammonium chloride was used as carrier in the SLM.…”

“…116 Implementation of more advanced extraction chemistries involve the use of ionic liquids 117 and the use of carrier-mediated extraction. 118 In the latter paper, methyl trioctyl ammonium chloride was used as carrier in the SLM. The carrier facilitated ionic interactions with the target analyte (hydrophilic antihypertensive peptide VLPVPR) and was crucial for the transfer of analyte from human plasma and into the SLM.…”